| Accession | ARO:3004085 |
| CARD Short Name | lnuG |
| Definition | lnuG is a transposon-mediated lincosamide nucleotidyltransferase found in Enterococcus faecalis on Tn6260. |
| AMR Gene Family | lincosamide nucleotidyltransferase (LNU) |
| Drug Class | lincosamide antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Acinetobacter johnsoniip+wgs, Acinetobacter lwoffiiwgs, Enterococcus faecalisg+p+wgs, Enterococcus faeciumg+wgs, Escherichia colip+wgs, Klebsiella pneumoniaewgs, Ligilactobacillus animaliswgs, Morganella morganiig+wgs, Proteus mirabilisg+wgs, Proteus vulgariswgs, Providencia rettgeriwgs, Providencia stuartiiwgs, Salmonella entericawgs, Serratia marcescenswgs |
| Resistomes with Sequence Variants | Acinetobacter johnsoniip+wgs, Acinetobacter lwoffiiwgs, Citrobacter portucalensiswgs, Citrobacter werkmaniip, Enterobacter cloacaep, Enterobacter hormaecheip+wgs, Enterococcus faecalisg+p+wgs, Enterococcus faeciumg+wgs, Enterococcus hiraewgs, Escherichia colip+wgs, Escherichia fergusoniip+wgs, Jeotgalibaca porcig, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaep, Ligilactobacillus animaliswgs, Listeria monocytogeneswgs, Morganella morganiig+wgs, Proteus mirabilisg+p+wgs, Proteus vulgariswgs, Providencia rettgeriwgs, Providencia stuartiiwgs, Salmonella entericawgs, Serratia marcescenswgs, Staphylococcus aureusg+wgs, Staphylococcus simulanswgs |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic molecule + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + lincosamide antibiotic [Drug Class] + antibiotic inactivation enzyme + nucleotidylation of antibiotic conferring resistance |
| Parent Term(s) | 2 ontology terms | Show + lincosamide nucleotidyltransferase (LNU) [AMR Gene Family] + confers_resistance_to_antibiotic lincomycin [Antibiotic] |
| Publications | Zhu XQ, et al. 2017. J. Antimicrob. Chemother. 72(4):993-997 Novel lnu(G) gene conferring resistance to lincomycin by nucleotidylation, located on Tn6260 from Enterococcus faecalis E531. (PMID 28039271) |
Prevalence of lnuG among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter johnsonii | 0% | 1.39% | 1.82% | 0% |
| Acinetobacter lwoffii | 0% | 0% | 2.63% | 0% |
| Citrobacter portucalensis | 0% | 0% | 1.8% | 0% |
| Citrobacter werkmanii | 0% | 10% | 0% | 0% |
| Enterobacter cloacae | 0% | 0.56% | 0% | 0% |
| Enterobacter hormaechei | 0% | 0.06% | 0.04% | 0% |
| Enterococcus faecalis | 5% | 0.49% | 1.07% | 0% |
| Enterococcus faecium | 1.27% | 0% | 1.83% | 0% |
| Enterococcus hirae | 0% | 0% | 0.93% | 0% |
| Escherichia coli | 0% | 0.12% | 0.39% | 0% |
| Escherichia fergusonii | 0% | 0.36% | 1.09% | 0% |
| Jeotgalibaca porci | 100% | 0% | 0% | 0% |
| Klebsiella pneumoniae | 0% | 0.03% | 0.06% | 0% |
| Klebsiella quasipneumoniae | 0% | 0.21% | 0% | 0% |
| Ligilactobacillus animalis | 0% | 0% | 8.33% | 0% |
| Listeria monocytogenes | 0% | 0% | 0.02% | 0% |
| Morganella morganii | 1.92% | 0% | 1.84% | 0% |
| Proteus mirabilis | 1.83% | 1.25% | 2.15% | 0% |
| Proteus vulgaris | 0% | 0% | 5.56% | 0% |
| Providencia rettgeri | 0% | 0% | 6.37% | 0% |
| Providencia stuartii | 0% | 0% | 2.27% | 0% |
| Salmonella enterica | 0% | 0% | 0.29% | 0% |
| Serratia marcescens | 0% | 0% | 0.13% | 0% |
| Staphylococcus aureus | 0.09% | 0% | 0.12% | 0% |
| Staphylococcus simulans | 0% | 0% | 3.39% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 450