| Accession | ARO:3001214 |
| Synonym(s) | ECK4328 JW4300 yjiO |
| CARD Short Name | mdtM |
| Definition | Multidrug resistance protein MdtM. |
| AMR Gene Family | major facilitator superfamily (MFS) antibiotic efflux pump |
| Drug Class | nucleoside antibiotic, disinfecting agents and antiseptics, phenicol antibiotic, lincosamide antibiotic, fluoroquinolone antibiotic |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Resistomes with Perfect Matches | Escherichia colig+wgs+gi |
| Resistomes with Sequence Variants | Escherichia albertiig+wgs, Escherichia colig+p+wgs+gi, Escherichia fergusoniig+wgs, Shigella boydiig+wgs, Shigella dysenteriaeg+wgs, Shigella flexnerig+wgs, Shigella sonneig+wgs |
| Classification | 12 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + nucleoside antibiotic [Drug Class] + determinant of antibiotic resistance + antibiotic efflux [Resistance Mechanism] + disinfecting agents and antiseptics [Drug Class] + phenicol antibiotic [Drug Class] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + aminonucleoside antibiotic + lincosamide antibiotic [Drug Class] + fluoroquinolone antibiotic [Drug Class] |
| Parent Term(s) | 6 ontology terms | Show + confers_resistance_to_antibiotic acriflavine [Antibiotic] + confers_resistance_to_antibiotic lincomycin [Antibiotic] + confers_resistance_to_antibiotic puromycin [Antibiotic] + major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family] + confers_resistance_to_antibiotic chloramphenicol [Antibiotic] + confers_resistance_to_antibiotic norfloxacin [Antibiotic] |
| Publications | Holdsworth SR and Law CJ. 2013. J Antimicrob Chemother 68(4): 831-839. The major facilitator superfamily transporter MdtM contributes to the intrinsic resistance of Escherichia coli to quaternary ammonium compounds. (PMID 23221628) |
Prevalence of mdtM among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Escherichia albertii | 1.43% | 0% | 2.58% | 0% |
| Escherichia coli | 57.91% | 0.01% | 53.6% | 2.04% |
| Escherichia fergusonii | 98.36% | 0% | 47.83% | 0% |
| Shigella boydii | 80% | 0% | 91.11% | 0% |
| Shigella dysenteriae | 100% | 0% | 60% | 0% |
| Shigella flexneri | 35% | 0% | 3.26% | 0% |
| Shigella sonnei | 2.44% | 0% | 4.09% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 700