mef(J)

Accession ARO:3007049
Synonym(s)mefJ
CARD Short Namemef(J)
Definitionmef(J) is an mef efflux pump protein.
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump
Drug Classmacrolide antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Resistomes with Perfect MatchesStreptococcus pyogenesg
Resistomes with Sequence VariantsLactococcus garvieaewgs, Streptococcus agalactiaewgs, Streptococcus pyogenesg, Streptococcus uberiswgs
Classification8 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ mef
Resistomes

Prevalence of mef(J) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Lactococcus garvieae0%0%2.22%0%
Streptococcus agalactiae0%0%0.06%0%
Streptococcus pyogenes0.37%0%0%0%
Streptococcus uberis0%0%0.89%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 500


>gb|QQA64076.1|-|mef(J) [Streptococcus pyogenes]
MENNKWKQKFFAIYTGQFFSLLSSAAVQFGIIWWLTDKTGGSPLLLTLAGLAGFLPQALVGPFAGTITDRYSRKFLMISADMTVALGSLI
LFLILHFYEANIIFVILILALRSLATAFHMPAMQASIPLLAPEEALTKVAGWGQMVASVSNIVGPAVGMSILSVSSIKWVLLLDILGAVV
ASGILLFINIPKIQKTESVELTSFFVEMKEGYNALVNHPILLKLTILMTIVAVLYIPLGTYFPLMTRNHFGKGVVEAGTVEIAFAIGLIV
GGSLLGIIGDKFEKVKTMAIGMLLMGLALFFSGLLSPSLFFIFIILSGLVGFSGPLFSAPFYAYIQTEIEPQLLGRIFSFVTSLSLLATP
IGYALSGLLIEFTSVSILFSIIGVLVILSGLITLKVK


>gb|CP065927.1|-|1659729-1660922|mef(J) [Streptococcus pyogenes]
ATGGAAAACAACAAATGGAAGCAGAAGTTTTTTGCAATATATACAGGACAATTCTTTTCACTATTAAGTAGTGCGGCCGTTCAATTTGGT
ATTATTTGGTGGCTAACTGATAAAACTGGTGGTTCACCATTGCTTCTAACACTAGCAGGACTTGCAGGTTTTTTACCACAAGCATTAGTA
GGACCTTTTGCTGGCACGATTACAGACCGTTATTCACGGAAGTTTTTGATGATTTCAGCAGATATGACTGTTGCGTTAGGTAGTTTAATT
TTATTTTTAATATTGCATTTCTATGAGGCTAATATCATTTTTGTAATTCTGATTTTAGCACTTAGATCATTAGCAACTGCTTTTCATATG
CCAGCAATGCAAGCATCAATTCCTTTACTTGCCCCTGAAGAAGCATTGACAAAGGTCGCTGGTTGGGGGCAAATGGTAGCATCCGTTTCT
AATATAGTAGGACCAGCTGTAGGGATGTCAATTCTTTCAGTGAGCTCAATTAAATGGGTACTACTTTTAGATATACTTGGAGCTGTAGTT
GCAAGTGGGATTTTACTTTTTATAAATATACCTAAAATACAAAAAACTGAATCTGTTGAACTTACAAGTTTTTTTGTAGAAATGAAAGAA
GGGTATAATGCCCTTGTTAATCATCCTATCTTGTTGAAACTTACAATACTTATGACAATCGTAGCAGTCCTATACATACCACTTGGAACT
TACTTCCCACTTATGACAAGAAATCATTTTGGGAAAGGTGTTGTTGAAGCTGGTACAGTAGAGATTGCATTTGCTATCGGTTTAATAGTA
GGCGGTTCATTGTTAGGTATAATAGGTGATAAATTTGAAAAAGTGAAGACAATGGCAATTGGAATGCTATTGATGGGACTGGCACTATTT
TTCTCTGGTCTTCTCTCACCATCACTTTTCTTTATCTTTATAATTTTGTCCGGATTGGTTGGATTTTCAGGACCTTTATTTTCTGCACCA
TTCTATGCTTATATTCAAACTGAGATTGAGCCACAATTATTAGGAAGAATTTTCAGTTTTGTAACAAGTCTCTCACTTTTAGCCACGCCA
ATTGGATATGCATTATCTGGTTTACTAATTGAATTTACTAGTGTTTCTATATTGTTTTCAATCATTGGTGTATTAGTAATACTAAGTGGT
CTTATTACTTTAAAAGTGAAATAG