| Accession | ARO:3003107 |
| Synonym(s) | mefB |
| CARD Short Name | mef(B) |
| Definition | mef(B) is a macrolide efflux gene located in the vicinity of sul3 in Escherichia coli. There is also a mefB found in Streptococcus agalactiae that confers resistance to macrolides. |
| AMR Gene Family | major facilitator superfamily (MFS) antibiotic efflux pump |
| Drug Class | macrolide antibiotic |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Resistomes with Perfect Matches | Avibacterium paragallinarumg, Citrobacter werkmaniiwgs, Escherichia colig+p+wgs, Escherichia fergusoniiwgs, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaewgs, Pasteurella multocidag+gi, Salmonella entericap+wgs, Shigella boydiiwgs, Shigella dysenteriaeg, Shigella flexnerip, Shigella sonneiwgs |
| Resistomes with Sequence Variants | Avibacterium paragallinarumg, Citrobacter werkmaniiwgs, Escherichia colig+p+wgs+gi, Escherichia fergusoniiwgs, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaewgs, Pasteurella multocidag+gi, Salmonella entericap+wgs+gi, Shigella boydiiwgs, Shigella dysenteriaeg, Shigella flexnerip, Shigella sonneiwgs |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic efflux [Resistance Mechanism] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + antibiotic molecule + major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family] + macrolide antibiotic [Drug Class] |
| Parent Term(s) | 3 ontology terms | Show + mef + confers_resistance_to_antibiotic erythromycin [Antibiotic] + confers_resistance_to_antibiotic azithromycin [Antibiotic] |
| Publications | Kumar S, et al. 2016. Infect Disord Drug Targets 16(1):28-43 Bacterial Multidrug Efflux Pumps of the Major Facilitator Superfamily as Targets for Modulation. (PMID 27052334) Liu J, et al. 2009. J Antimicrob Chemother 63(3): 423-426. Characterization of a novel macrolide efflux gene, mef(B), found linked to sul3 in porcine Escherichia coli. (PMID 19131424) |
Prevalence of mef(B) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Avibacterium paragallinarum | 6.25% | 0% | 0% | 0% |
| Citrobacter werkmanii | 0% | 0% | 2.56% | 0% |
| Escherichia coli | 0.07% | 0.24% | 0.65% | 0.38% |
| Escherichia fergusonii | 0% | 0% | 1.09% | 0% |
| Klebsiella pneumoniae | 0% | 0.14% | 0.17% | 0% |
| Klebsiella quasipneumoniae | 0% | 0% | 0.13% | 0% |
| Pasteurella multocida | 0.71% | 0% | 0% | 16.67% |
| Salmonella enterica | 0% | 0.11% | 0.1% | 0.66% |
| Shigella boydii | 0% | 0% | 2.22% | 0% |
| Shigella dysenteriae | 14.29% | 0% | 0% | 0% |
| Shigella flexneri | 0% | 0.8% | 0% | 0% |
| Shigella sonnei | 0% | 0% | 0.15% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 800