Accession ARO:3000515
DefinitionEvgSA is a two-component regulatory system that regulates MdtEF and EmrKY expression for multidrug resistance. EvgS is a sensor protein that phosphorylates the regulatory protein EvgA, though EvgA can be phosphorylated by other methods when it is overexpressed.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump, major facilitator superfamily (MFS) antibiotic efflux pump
Drug Classpenam, fluoroquinolone antibiotic, macrolide antibiotic, tetracycline antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Efflux Regulatorprotein(s) and two-component regulatory system modulating antibiotic efflux
Classification18 ontology terms | Show
Parent Term(s)3 ontology terms | Show
2 ontology terms | Show
+ evgA part_of
+ evgS part_of

Nishino K and Yamaguchi A. 2002. J Bacteriol 184(8): 2319-2323. EvgA of the two-component signal transduction system modulates production of the yhiUV multidrug transporter in Escherichia coli. (PMID 11914367)