Accession ARO:3000373
DefinitionEmrKY is a homolog of EmrAB found in E. coli. Together with TolC, it is a tripartite multidrug transporter.
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump
Drug Classtetracycline antibiotic, diaminopyrimidine antibiotic, rifamycin antibiotic, cephalosporin, glycylcycline, antibacterial free fatty acids, benzalkonium chloride, macrolide antibiotic, penam, nucleoside antibiotic, phenicol antibiotic, fosfomycin, acridine dye, peptide antibiotic, rhodamine, fluoroquinolone antibiotic, oxazolidinone antibiotic, nitroimidazole antibiotic, isoniazid, bicyclomycin, lincosamide antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification30 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family]
5 ontology terms | Show
+ emrK part_of
+ emrY part_of
+ TolC part_of
+ evgSA regulates
+ H-NS regulates

Prevalence of EmrKY-TolC among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: efflux pump system meta-model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data

Detection Models

Model Name: EmrKY-TolC

Model Description: EmrKY is a homolog of EmrAB found in E. coli. Together with TolC, it is a tripartite multidrug transporter.