EmrKY-TolC

Download Sequences

Accession	ARO:3000373
Definition	EmrKY is a homolog of EmrAB found in E. coli. Together with TolC, it is a tripartite multidrug transporter.
AMR Gene Family	major facilitator superfamily (MFS) antibiotic efflux pump
Drug Class	tetracycline antibiotic, diaminopyrimidine antibiotic, rifamycin antibiotic, cephalosporin, glycylcycline, antibacterial free fatty acids, benzalkonium chloride, macrolide antibiotic, penam, nucleoside antibiotic, phenicol antibiotic, fosfomycin, acridine dye, peptide antibiotic, rhodamine, fluoroquinolone antibiotic, oxazolidinone antibiotic, nitroimidazole antibiotic, isoniazid, bicyclomycin, lincosamide antibiotic
Resistance Mechanism	antibiotic efflux
Efflux Component	efflux pump complex or subunit conferring antibiotic resistance
Classification	30 ontology terms \| Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + beta-lactam antibiotic + determinant of antibiotic resistance + antibiotic without defined classification + tetracycline antibiotic [Drug Class] + antibiotic efflux [Resistance Mechanism] + cephem + diaminopyrimidine antibiotic [Drug Class] + rifamycin antibiotic [Drug Class] + cephalosporin [Drug Class] + glycylcycline [Drug Class] + antibacterial free fatty acids [Drug Class] + benzalkonium chloride [Drug Class] + macrolide antibiotic [Drug Class] + penam [Drug Class] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + nucleoside antibiotic [Drug Class] + phenicol antibiotic [Drug Class] + fosfomycin [Drug Class] + acridine dye [Drug Class] + peptide antibiotic [Drug Class] + rhodamine [Drug Class] + fluoroquinolone antibiotic [Drug Class] + oxazolidinone antibiotic [Drug Class] + nitroimidazole antibiotic [Drug Class] + isoniazid [Drug Class] + bicyclomycin [Drug Class] + lincosamide antibiotic [Drug Class]
Parent Term(s)	2 ontology terms \| Show + confers_resistance_to_antibiotic tetracycline [Antibiotic] + major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family]
Sub-Term(s)	5 ontology terms \| Show + emrK part_of + emrY part_of + TolC part_of + evgSA regulates + H-NS regulates

Resistomes

Prevalence of EmrKY-TolC among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: efflux pump system meta-model

Species	NCBI Chromosome	NCBI Plasmid	NCBI WGS
No prevalence data

Detection Models

efflux pump system meta-model

Model Name: EmrKY-TolC

Model Description: EmrKY is a homolog of EmrAB found in E. coli. Together with TolC, it is a tripartite multidrug transporter.

evgAemrYemrKevgSH-NStolC

EmrKY-TolC

Prevalence: efflux pump system meta-model

Graph