Accession ARO:3000373
CARD Short NameEmrKY-TolC
DefinitionEmrKY is a homolog of EmrAB found in E. coli. Together with TolC, it is a tripartite multidrug transporter.
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump
Drug Classtetracycline antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification7 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
5 ontology terms | Show
+ emrK part_of
+ emrY part_of
+ TolC part_of
+ evgSA regulates
+ H-NS regulates

Tanabe H, et al. 1997. J Gen Appl Microbiol 43(5): 257-263. Growth phase-dependent transcription of emrKY, a homolog of multidrug efflux emrAB genes of Escherichia coli, is induced by tetracycline. (PMID 12501312)

Zgurskaya HI, et al. 2011. Front Microbiol 2:189 Mechanism and Function of the Outer Membrane Channel TolC in Multidrug Resistance and Physiology of Enterobacteria. (PMID 21954395)


Prevalence of EmrKY-TolC among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: efflux pump system meta-model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data

Detection Models

Model Name: EmrKY-TolC

Model Description: EmrKY is a homolog of EmrAB found in E. coli. Together with TolC, it is a tripartite multidrug transporter.