| Accession | ARO:0000011 |
| Synonym(s) | Chloroxacillin Clossacillina Cloxacilina Cloxacilline Cloxacillinum Cloxapen Methocillin S Orbenin Syntarpen Tegopen |
| Definition | Cloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections. |
| SMILES | Cc1onc(-c2ccccc2Cl)c1C(=O)N[C@@H]1C(=O)N2[C@@H]1SC(C)(C)[C@@H]2C(=O)O |
| PubChem | 6098 |
| ChEBI | 49566 |
| CAS | 61-72-3 |
| ChEMBL | CHEMBL891 |
| Drug Class | penicillin beta-lactam |
| Classification | 4 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show |
| Sub-Term(s) | 5 ontology terms | Show + beta-lactam sensitive penicillin-binding protein targeted_by_antibiotic + MdtEF-TolC confers_resistance_to_antibiotic + ceftazidime-cloxacillin [Antibiotic] has_part + cefepime-cloxacillin [Antibiotic] has_part + imipenem-cloxacillin [Antibiotic] has_part |
| Publications | Jacoby GA and Munoz-Price LS. 2005. N Engl J Med 352(4): 380-391. The new beta-lactamases. (PMID 15673804) Bradford PA. 2001. Clin Microbiol Rev 14(4): 933-951. Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. (PMID 11585791) Nauta EH and Mattie H. 1975. Br J Clin Pharmacol 2(2): 111-121. Pharmacokinetics of flucloxacillin and cloxacillin in healthy subjects and patients on chronic intermittent haemodialysis. (PMID 1234495) |
| Curator | Description | Most Recent Edit |
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