cloxacillin [Antibiotic]

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Accession ARO:0000011
Synonym(s)Cloxacillinum Tegopen Cloxacilline Orbenin Chloroxacillin Cloxacilina Clossacillina Syntarpen Cloxapen Methocillin S
DefinitionCloxacillin is a semisynthetic, isoxazolyl penicillin derivative in the beta-lactam class of antibiotics. It interferes with peptidogylcan synthesis and is commonly used for treating penicillin-resistant Staphylococcus aureus infections.
Drug Classpenam
Classification3 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ penam [Drug Class]
5 ontology terms | Show
+ beta-lactam sensitive penicillin-binding protein targeted_by_antibiotic
+ MdtEF-TolC confers_resistance_to_antibiotic
+ ceftazidime-cloxacillin [Antibiotic] has_part
+ cefepime-cloxacillin [Antibiotic] has_part
+ imipenem-cloxacillin [Antibiotic] has_part

Jacoby GA and Munoz-Price LS. 2005. N Engl J Med 352(4): 380-391. The new beta-lactamases. (PMID 15673804)

Bradford PA. 2001. Clin Microbiol Rev 14(4): 933-951. Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. (PMID 11585791)

Nauta EH and Mattie H. 1975. Br J Clin Pharmacol 2(2): 111-121. Pharmacokinetics of flucloxacillin and cloxacillin in healthy subjects and patients on chronic intermittent haemodialysis. (PMID 1234495)