CRP

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Accession ARO:3000518
CARD Short NameCRP
DefinitionCRP is a global regulator that represses MdtEF multidrug efflux pump expression.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classpenam, fluoroquinolone antibiotic, macrolide antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Efflux Regulatorprotein(s) and two-component regulatory system modulating antibiotic efflux
Resistomes with Perfect MatchesEscherichia colig
Resistomes with Sequence VariantsCitrobacter amalonaticusg+wgs, Citrobacter freundiig+wgs, Citrobacter koserig+wgs, Citrobacter portucalensisg+wgs, Citrobacter werkmaniig+wgs, Citrobacter youngaeg+wgs, Cronobacter condimentig+wgs, Cronobacter dublinensisg+wgs, Cronobacter malonaticusg+wgs, Cronobacter sakazakiig+wgs, Cronobacter turicensiswgs, Cronobacter universalisg+wgs, Edwardsiella tardag+wgs, Enterobacter asburiaeg+wgs, Enterobacter cancerogenusg+wgs, Enterobacter chengduensisg+wgs, Enterobacter cloacaeg+p+wgs, Enterobacter hormaecheig+wgs, Enterobacter kobeig+wgs, Enterobacter roggenkampiig+wgs, Escherichia albertiig+wgs, Escherichia colig+wgs, Escherichia fergusoniig+wgs, Escherichia marmotaeg+wgs, Klebsiella aerogenesg+wgs, Klebsiella huaxiensisg+wgs, Klebsiella michiganensisg+wgs, Klebsiella oxytocag+p+wgs, Klebsiella pneumoniaeg+wgs, Klebsiella quasipneumoniaeg+wgs, Kosakonia arachidisg+wgs, Leclercia adecarboxylatag+wgs, Leminorella grimontiiwgs, Morganella morganiig+p+wgs, Pectobacterium parmentierig+wgs, Photorhabdus asymbioticag+wgs, Plesiomonas shigelloidesg+wgs, Proteus columbaeg+wgs, Proteus mirabilisg+wgs, Proteus pennerig+wgs, Proteus vulgarisg+wgs, Providencia alcalifaciensg+wgs, Providencia heimbachaeg+wgs, Providencia rettgerig+wgs, Providencia stuartiig+wgs, Raoultella planticolag+wgs, Salmonella bongorig+wgs, Salmonella entericag+wgs, Serratia liquefaciensg+wgs, Serratia marcescensg+p+wgs, Serratia odoriferag+wgs, Serratia rubidaeag+wgs, Shigella boydiig+wgs, Shigella dysenteriaeg+wgs, Shigella flexnerig+wgs, Shigella sonneig+wgs, Vibrio alginolyticusg+wgs, Vibrio choleraeg+wgs, Vibrio fluvialisg+wgs, Vibrio harveyig+wgs, Vibrio metoecusg+wgs, Vibrio mimicusg+wgs, Vibrio neocaledonicusg, Vibrio owensiig+wgs, Vibrio parahaemolyticusg+wgs, Vibrio vulnificusg+wgs, Yersinia canariaeg+wgs, Yersinia enterocoliticag+wgs, Yersinia kristenseniig+wgs, Yersinia pestisg+wgs, Yersinia pseudotuberculosisg+wgs
Classification15 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Nishino K, et al. 2008. J Antibiot (Tokyo) 61(3): 120-127. CRP regulator modulates multidrug resistance of Escherichia coli by repressing the mdtEF multidrug efflux genes. (PMID 18503189)
Resistomes

Prevalence of CRP among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Citrobacter amalonaticus100%0%89.09%0%
Citrobacter freundii100%0%50.87%0%
Citrobacter koseri100%0%49.55%0%
Citrobacter portucalensis100%0%62.16%0%
Citrobacter werkmanii100%0%61.54%0%
Citrobacter youngae100%0%100%0%
Cronobacter condimenti100%0%100%0%
Cronobacter dublinensis100%0%100%0%
Cronobacter malonaticus100%0%85.45%0%
Cronobacter sakazakii100%0%92.38%0%
Cronobacter turicensis0%0%83.33%0%
Cronobacter universalis100%0%100%0%
Edwardsiella tarda100%0%93.33%0%
Enterobacter asburiae100%0%70.75%0%
Enterobacter cancerogenus100%0%100%0%
Enterobacter chengduensis100%0%84%0%
Enterobacter cloacae100%0.56%73.16%0%
Enterobacter hormaechei99.28%0%67.16%0%
Enterobacter kobei100%0%68.56%0%
Enterobacter roggenkampii100%0%62.23%0%
Escherichia albertii100%0%62.58%0%
Escherichia coli67.96%0%61.89%0%
Escherichia fergusonii100%0%51.09%0%
Escherichia marmotae100%0%70.83%0%
Klebsiella aerogenes100%0%79.94%0%
Klebsiella huaxiensis100%0%66.67%0%
Klebsiella michiganensis100%0%69.41%0%
Klebsiella oxytoca100%0.68%75.21%0%
Klebsiella pneumoniae99.64%0%57.36%0%
Klebsiella quasipneumoniae100%0%73.68%0%
Kosakonia arachidis100%0%100%0%
Leclercia adecarboxylata100%0%60.47%0%
Leminorella grimontii0%0%85.71%0%
Morganella morganii100%2.5%55.83%0%
Pectobacterium parmentieri100%0%94.12%0%
Photorhabdus asymbiotica100%0%100%0%
Plesiomonas shigelloides87.5%0%89.66%0%
Proteus columbae100%0%100%0%
Proteus mirabilis100%0%42.9%0%
Proteus penneri100%0%100%0%
Proteus vulgaris100%0%88.89%0%
Providencia alcalifaciens100%0%96.55%0%
Providencia heimbachae100%0%71.43%0%
Providencia rettgeri100%0%54.14%0%
Providencia stuartii100%0%70.45%0%
Raoultella planticola100%0%94.87%0%
Salmonella bongori100%0%94.74%0%
Salmonella enterica95.65%0%81.29%0%
Serratia liquefaciens100%0%50.79%0%
Serratia marcescens100%1.94%78.11%0%
Serratia odorifera100%0%100%0%
Serratia rubidaea100%0%81.82%0%
Shigella boydii100%0%97.78%0%
Shigella dysenteriae100%0%100%0%
Shigella flexneri100%0%82.3%0%
Shigella sonnei100%0%96.06%0%
Vibrio alginolyticus49.38%0%25.79%0%
Vibrio cholerae50.67%0%78.98%0%
Vibrio fluvialis50%0%32%0%
Vibrio harveyi50%0%78%0%
Vibrio metoecus50%0%100%0%
Vibrio mimicus50%0%100%0%
Vibrio neocaledonicus50%0%0%0%
Vibrio owensii50%0%84.21%0%
Vibrio parahaemolyticus50%0%73.93%0%
Vibrio vulnificus49.09%0%73.88%0%
Yersinia canariae100%0%50%0%
Yersinia enterocolitica100%0%74.55%0%
Yersinia kristensenii100%0%65.71%0%
Yersinia pestis100%0%78.91%0%
Yersinia pseudotuberculosis100%0%98.53%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 400


>gb|BAE77933.1|-|CRP [Escherichia coli str. K-12 substr. W3110]
MVLGKPQTDPTLEWFLSHCHIHKYPSKSKLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEGQERSAWVRAK
TACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCS
RETVGRILKMLEDQNLISAHGKTIVVYGTR


>gb|AP009048.1|-|4153664-4154296|CRP [Escherichia coli str. K-12 substr. W3110]
ATGGTGCTTGGCAAACCGCAAACAGACCCGACTCTCGAATGGTTCTTGTCTCATTGCCACATTCATAAGTACCCATCCAAGAGCAAGCTT
ATTCACCAGGGTGAAAAAGCGGAAACGCTGTACTACATCGTTAAAGGCTCTGTGGCAGTGCTGATCAAAGACGAAGAGGGTAAAGAAATG
ATCCTCTCCTATCTGAATCAGGGTGATTTTATTGGCGAACTGGGCCTGTTTGAAGAGGGCCAGGAACGTAGCGCATGGGTACGTGCGAAA
ACCGCCTGTGAAGTGGCTGAAATTTCGTACAAAAAATTTCGCCAATTGATTCAGGTAAACCCGGACATTCTGATGCGTTTGTCTGCACAG
ATGGCGCGTCGTCTGCAAGTCACTTCAGAGAAAGTGGGCAACCTGGCGTTCCTCGACGTGACGGGCCGCATTGCACAGACTCTGCTGAAT
CTGGCAAAACAACCAGACGCTATGACTCACCCGGACGGTATGCAAATCAAAATTACCCGTCAGGAAATTGGTCAGATTGTCGGCTGTTCT
CGTGAAACCGTGGGACGCATTCTGAAGATGCTGGAAGATCAGAACCTGATCTCCGCACACGGTAAAACCATCGTCGTTTACGGCACTCGT
TAA