efmA

Accession ARO:3003954
CARD Short NameefmA
DefinitionefmA is an MFS transporter permease in E. faecium.
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump
Drug Classmacrolide antibiotic, fluoroquinolone antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Resistomes with Perfect MatchesEnterococcus faeciumg+wgs
Resistomes with Sequence VariantsEnterococcus faecaliswgs, Enterococcus faeciumg+wgs
Classification7 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_drug_class fluoroquinolone antibiotic [Drug Class]
+ confers_resistance_to_antibiotic erythromycin [Antibiotic]
Publications

Nishioka T, et al. 2009. Biol. Pharm. Bull. 32(3):483-8 Gene cloning and characterization of EfmA, a multidrug efflux pump, from Enterococcus faecium. (PMID 19252300)

Resistomes

Prevalence of efmA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Enterococcus faecalis0%0%0.08%0%
Enterococcus faecium83.12%0%49.88%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 800


>gb|BAG75524.1|+|efmA [Enterococcus faecium]
MENEQSVVLTNWKRNYLFFLSGQFLSGITSMVVQYAIIWYLTRETGSATILSFATLLGMIPMVLLSPFVGPLVDRWDKKALLIVTDIIVA
IFALILAVVGTISESFPIWLVFVSLFMRSVAQTFQMPTIQSIMPTIVPSSHITRTNGQLGMVQSANFIIAPALGAALFSVVPVNYLILLD
VLGAVFGVGLLIFVKIPKVSPEILEVPLTIFKDAKFGLQQLMDNKGLWYITINGAFVMLLFMPAISLYPLMTLDYFGGSVGQAGAVEVVY
AVGMLLGGALISFIGTWKDRMKPIIIAYIIMGLTIGASGLVPNDSQGFLYFLILNAGAGCATPYFNTLLMAMIQQSYESNVLGRVLGNFN
SLMNLAGPIGLLFAGPLADRLGVEKMFLFSGIGILLCGIVLFLTSAARNYDKELQKKLVKEHHEQKDE


>gb|AB467372.1|+|285-1571|efmA [Enterococcus faecium]
ATGGAAAATGAACAGTCGGTCGTTTTAACGAATTGGAAGAGAAATTATTTGTTCTTTTTATCGGGACAGTTTTTGTCAGGAATCACTAGT
ATGGTCGTCCAATATGCGATCATCTGGTATTTGACAAGAGAAACCGGTTCGGCGACAATTTTGAGTTTTGCTACTTTACTAGGAATGATT
CCCATGGTTTTACTAAGCCCATTTGTAGGACCGCTAGTGGATCGCTGGGATAAAAAAGCTCTTTTGATTGTCACGGATATTATTGTAGCG
ATTTTCGCGCTTATTTTAGCAGTAGTCGGAACGATTTCAGAATCCTTCCCGATTTGGCTAGTTTTTGTGTCTTTGTTTATGCGTTCGGTC
GCACAAACATTCCAAATGCCAACGATCCAGTCGATTATGCCGACAATCGTTCCATCTTCTCACATAACAAGGACGAATGGACAGTTAGGA
ATGGTCCAATCAGCGAATTTCATCATTGCGCCAGCTCTAGGTGCGGCTTTGTTTTCAGTCGTTCCTGTCAATTACCTTATTTTATTAGAT
GTATTGGGGGCAGTTTTTGGTGTCGGCTTATTGATTTTTGTGAAGATCCCAAAAGTTTCTCCTGAAATATTGGAAGTTCCGCTTACTATT
TTTAAAGATGCAAAATTTGGGCTGCAGCAATTGATGGATAATAAAGGGTTATGGTACATAACGATCAATGGTGCATTTGTGATGCTGTTG
TTCATGCCAGCAATCAGTCTGTATCCATTGATGACGCTAGATTACTTTGGTGGTTCCGTTGGACAGGCGGGAGCAGTGGAAGTAGTCTAC
GCAGTCGGAATGCTCTTAGGCGGTGCACTGATCAGTTTTATAGGAACATGGAAAGACCGAATGAAACCTATTATTATAGCCTACATCATT
ATGGGCCTGACGATCGGTGCAAGCGGATTGGTTCCAAACGATAGTCAAGGGTTCTTGTACTTTCTTATCTTGAATGCAGGAGCAGGTTGT
GCAACGCCATATTTCAATACACTGCTGATGGCAATGATCCAGCAGAGTTATGAATCGAATGTTTTAGGTCGTGTCTTAGGGAACTTCAAC
TCTTTGATGAACCTGGCAGGTCCAATTGGATTATTATTTGCAGGACCATTAGCTGATCGTTTAGGGGTAGAAAAAATGTTCTTGTTTTCC
GGAATCGGGATTTTATTATGCGGAATCGTTTTATTTTTAACGTCAGCTGCCCGAAATTATGATAAAGAATTACAGAAAAAACTGGTAAAA
GAACACCATGAGCAAAAAGACGAATAG