efmA

Accession ARO:3003954
DefinitionefmA is an MFS transporter permease in E. faecium.
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump
Drug Classmacrolide antibiotic, fluoroquinolone antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
ResistomesEnterococcus faeciumg+wgs
Classification7 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ confers_resistance_to_drug_class fluoroquinolone antibiotic [Drug Class]
+ confers_resistance_to_antibiotic erythromycin [Antibiotic]
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family]
Publications

Nishioka T, et al. 2009. Biol. Pharm. Bull. 32(3):483-8 Gene cloning and characterization of EfmA, a multidrug efflux pump, from Enterococcus faecium. (PMID 19252300)

Resistomes

Prevalence of efmA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Acinetobacter baumannii0%0%0.04%
Enterococcus faecalis0%0%0.26%
Enterococcus faecium94.4%0%84.73%
Staphylococcus aureus0%0%0.01%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 800


>gb|BAG75524.1|+|efmA [Enterococcus faecium]
MENEQSVVLTNWKRNYLFFLSGQFLSGITSMVVQYAIIWYLTRETGSATILSFATLLGMIPMVLLSPFVGPLVDRWDKKALLIVTDIIVA
IFALILAVVGTISESFPIWLVFVSLFMRSVAQTFQMPTIQSIMPTIVPSSHITRTNGQLGMVQSANFIIAPALGAALFSVVPVNYLILLD
VLGAVFGVGLLIFVKIPKVSPEILEVPLTIFKDAKFGLQQLMDNKGLWYITINGAFVMLLFMPAISLYPLMTLDYFGGSVGQAGAVEVVY
AVGMLLGGALISFIGTWKDRMKPIIIAYIIMGLTIGASGLVPNDSQGFLYFLILNAGAGCATPYFNTLLMAMIQQSYESNVLGRVLGNFN
SLMNLAGPIGLLFAGPLADRLGVEKMFLFSGIGILLCGIVLFLTSAARNYDKELQKKLVKEHHEQKDE


>gb|AB467372.1|+|285-1571|efmA [Enterococcus faecium]
ATGGAAAATGAACAGTCGGTCGTTTTAACGAATTGGAAGAGAAATTATTTGTTCTTTTTATCGGGACAGTTTTTGTCAGGAATCACTAGT
ATGGTCGTCCAATATGCGATCATCTGGTATTTGACAAGAGAAACCGGTTCGGCGACAATTTTGAGTTTTGCTACTTTACTAGGAATGATT
CCCATGGTTTTACTAAGCCCATTTGTAGGACCGCTAGTGGATCGCTGGGATAAAAAAGCTCTTTTGATTGTCACGGATATTATTGTAGCG
ATTTTCGCGCTTATTTTAGCAGTAGTCGGAACGATTTCAGAATCCTTCCCGATTTGGCTAGTTTTTGTGTCTTTGTTTATGCGTTCGGTC
GCACAAACATTCCAAATGCCAACGATCCAGTCGATTATGCCGACAATCGTTCCATCTTCTCACATAACAAGGACGAATGGACAGTTAGGA
ATGGTCCAATCAGCGAATTTCATCATTGCGCCAGCTCTAGGTGCGGCTTTGTTTTCAGTCGTTCCTGTCAATTACCTTATTTTATTAGAT
GTATTGGGGGCAGTTTTTGGTGTCGGCTTATTGATTTTTGTGAAGATCCCAAAAGTTTCTCCTGAAATATTGGAAGTTCCGCTTACTATT
TTTAAAGATGCAAAATTTGGGCTGCAGCAATTGATGGATAATAAAGGGTTATGGTACATAACGATCAATGGTGCATTTGTGATGCTGTTG
TTCATGCCAGCAATCAGTCTGTATCCATTGATGACGCTAGATTACTTTGGTGGTTCCGTTGGACAGGCGGGAGCAGTGGAAGTAGTCTAC
GCAGTCGGAATGCTCTTAGGCGGTGCACTGATCAGTTTTATAGGAACATGGAAAGACCGAATGAAACCTATTATTATAGCCTACATCATT
ATGGGCCTGACGATCGGTGCAAGCGGATTGGTTCCAAACGATAGTCAAGGGTTCTTGTACTTTCTTATCTTGAATGCAGGAGCAGGTTGT
GCAACGCCATATTTCAATACACTGCTGATGGCAATGATCCAGCAGAGTTATGAATCGAATGTTTTAGGTCGTGTCTTAGGGAACTTCAAC
TCTTTGATGAACCTGGCAGGTCCAATTGGATTATTATTTGCAGGACCATTAGCTGATCGTTTAGGGGTAGAAAAAATGTTCTTGTTTTCC
GGAATCGGGATTTTATTATGCGGAATCGTTTTATTTTTAACGTCAGCTGCCCGAAATTATGATAAAGAATTACAGAAAAAACTGGTAAAA
GAACACCATGAGCAAAAAGACGAATAG