| Accession | ARO:3000165 |
| Synonym(s) | tetA |
| CARD Short Name | tet(A) |
| Definition | TetA is a tetracycline efflux pump found in many species of Gram-negative bacteria. |
| AMR Gene Family | major facilitator superfamily (MFS) antibiotic efflux pump |
| Drug Class | tetracycline antibiotic |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Resistomes with Perfect Matches | Acinetobacter johnsoniiwgs, Aeromonas caviaeg, Citrobacter amalonaticuswgs, Citrobacter freundiiwgs, Citrobacter portucalensisp, Enterobacter cloacaewgs, Enterobacter hormaecheiwgs, Enterobacter roggenkampiiwgs, Escherichia colip+wgs, Escherichia fergusoniiwgs, Klebsiella michiganensisp, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaep, Morganella morganiiwgs, Proteus mirabilisg+wgs, Salmonella entericap+wgs, Shigella flexnerip+wgs, Shigella sonneiwgs, Stenotrophomonas maltophiliawgs, Vibrio choleraewgs |
| Resistomes with Sequence Variants | Acinetobacter baumanniig+wgs, Acinetobacter indicuswgs, Acinetobacter johnsoniiwgs, Aeromonas caviaeg+p+wgs, Aeromonas hydrophilag+p+wgs, Aeromonas veroniig+p+wgs, Alcaligenes faecalisg+wgs, Avibacterium paragallinarumg, Burkholderia cenocepaciawgs, Burkholderia glumaeg, Citrobacter amalonaticuswgs, Citrobacter freundiig+p+wgs, Citrobacter koserig+wgs, Citrobacter portucalensisg+p+wgs, Citrobacter werkmaniip+wgs, Citrobacter youngaep, Cronobacter dublinensiswgs, Cronobacter sakazakiip, Edwardsiella tardap+wgs, Enterobacter asburiaewgs, Enterobacter chengduensiswgs, Enterobacter cloacaeg+p+wgs, Enterobacter hormaecheig+p+wgs, Enterobacter kobeiwgs, Enterobacter roggenkampiip+wgs, Escherichia albertiig+p+wgs, Escherichia colig+p+wgs, Escherichia fergusoniig+p+wgs, Escherichia marmotaep+wgs, Klebsiella aerogenesg+p+wgs, Klebsiella michiganensisp+wgs, Klebsiella oxytocag+p+wgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaep+wgs, Laribacter hongkongensisg+wgs, Leclercia adecarboxylatap+wgs, Morganella morganiig+p+wgs, Pasteurella multocidawgs, Plesiomonas shigelloidesp+wgs, Proteus mirabilisg+p+wgs, Providencia alcalifaciensg, Providencia rettgeriwgs, Providencia stuartiip+wgs, Pseudomonas aeruginosag+p+wgs, Pseudomonas fluorescensp+wgs, Pseudomonas monteiliiwgs, Pseudomonas putidag+p+wgs, Salmonella entericag+p+wgs, Serratia liquefacienswgs, Serratia marcescensg+p+wgs, Shigella boydiip+wgs, Shigella dysenteriaep+wgs, Shigella flexnerig+p+wgs, Shigella sonneip+wgs, Stenotrophomonas maltophiliag+wgs, Vibrio alginolyticuswgs, Vibrio choleraeg+p+wgs, Vibrio fluvialisg+wgs, Vibrio parahaemolyticuswgs, Vibrio vulnificuswgs, Yersinia enterocoliticap+wgs, Yersinia pseudotuberculosiswgs |
| Classification | 7 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic efflux [Resistance Mechanism] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + tetracycline antibiotic [Drug Class] |
| Parent Term(s) | 2 ontology terms | Show + confers_resistance_to_antibiotic tetracycline [Antibiotic] + major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family] |
| Sub-Term(s) | 1 ontology terms | Show + tetR regulates |
| Publications | Aldema ML, et al. 1996. Mol Microbiol 19(1): 187-195. Purification of the Tn10-specified tetracycline efflux antiporter TetA in a native state as a polyhistidine fusion protein. (PMID 8821947) Roberts MC. 2005. FEMS Microbiol Lett 245(2): 195-203. Update on acquired tetracycline resistance genes. (PMID 15837373) |
Prevalence of tet(A) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 3.01% | 0% | 1.5% | 0% |
| Acinetobacter indicus | 0% | 0% | 1.3% | 0% |
| Acinetobacter johnsonii | 0% | 0% | 1.82% | 0% |
| Aeromonas caviae | 18.18% | 1.3% | 10.75% | 0% |
| Aeromonas hydrophila | 7.69% | 3.9% | 3.23% | 0% |
| Aeromonas veronii | 9.09% | 1.54% | 7.87% | 0% |
| Alcaligenes faecalis | 10% | 0% | 2.94% | 0% |
| Avibacterium paragallinarum | 6.25% | 0% | 0% | 0% |
| Burkholderia cenocepacia | 0% | 0% | 5.04% | 0% |
| Burkholderia glumae | 1% | 0% | 0% | 0% |
| Citrobacter amalonaticus | 0% | 0% | 7.27% | 0% |
| Citrobacter freundii | 1.64% | 3.08% | 13.73% | 0% |
| Citrobacter koseri | 6.25% | 0% | 2.7% | 0% |
| Citrobacter portucalensis | 3.7% | 4.41% | 14.41% | 0% |
| Citrobacter werkmanii | 0% | 20% | 20.51% | 0% |
| Citrobacter youngae | 0% | 9.09% | 0% | 0% |
| Cronobacter dublinensis | 0% | 0% | 2.56% | 0% |
| Cronobacter sakazakii | 0% | 2.56% | 0% | 0% |
| Edwardsiella tarda | 0% | 15.79% | 20% | 0% |
| Enterobacter asburiae | 0% | 0% | 4.35% | 0% |
| Enterobacter chengduensis | 0% | 0% | 12% | 0% |
| Enterobacter cloacae | 1.79% | 5.03% | 15.97% | 0% |
| Enterobacter hormaechei | 1.44% | 2.51% | 10.83% | 0% |
| Enterobacter kobei | 0% | 0% | 11.79% | 0% |
| Enterobacter roggenkampii | 0% | 1.93% | 7.55% | 0% |
| Escherichia albertii | 4.29% | 2.82% | 3.87% | 0% |
| Escherichia coli | 3.55% | 5.2% | 18.87% | 0% |
| Escherichia fergusonii | 8.2% | 8.19% | 28.26% | 0% |
| Escherichia marmotae | 0% | 3.12% | 2.08% | 0% |
| Klebsiella aerogenes | 4% | 2.17% | 3.11% | 0% |
| Klebsiella michiganensis | 0% | 2.86% | 5.59% | 0% |
| Klebsiella oxytoca | 2.56% | 2.74% | 6.3% | 0% |
| Klebsiella pneumoniae | 1.95% | 6.41% | 16.73% | 0% |
| Klebsiella quasipneumoniae | 0% | 4.24% | 22.37% | 0% |
| Laribacter hongkongensis | 66.67% | 0% | 6.25% | 0% |
| Leclercia adecarboxylata | 0% | 4.76% | 4.65% | 0% |
| Morganella morganii | 1.92% | 2.5% | 4.91% | 0% |
| Pasteurella multocida | 0% | 0% | 0.75% | 0% |
| Plesiomonas shigelloides | 0% | 16.67% | 17.24% | 0% |
| Proteus mirabilis | 9.17% | 1.25% | 4.62% | 0% |
| Providencia alcalifaciens | 9.09% | 0% | 0% | 0% |
| Providencia rettgeri | 0% | 0% | 1.91% | 0% |
| Providencia stuartii | 0% | 2.27% | 2.27% | 0% |
| Pseudomonas aeruginosa | 2.45% | 0.88% | 1.1% | 0% |
| Pseudomonas fluorescens | 0% | 11.11% | 0.43% | 0% |
| Pseudomonas monteilii | 0% | 0% | 4.76% | 0% |
| Pseudomonas putida | 1.41% | 12% | 0.53% | 0% |
| Salmonella enterica | 3.97% | 14.55% | 12.49% | 0% |
| Serratia liquefaciens | 0% | 0% | 3.17% | 0% |
| Serratia marcescens | 0.76% | 0.65% | 2.62% | 0% |
| Shigella boydii | 0% | 8.7% | 33.33% | 0% |
| Shigella dysenteriae | 0% | 4.55% | 13.33% | 0% |
| Shigella flexneri | 7% | 11.65% | 6.06% | 0% |
| Shigella sonnei | 0% | 8.74% | 37.62% | 0% |
| Stenotrophomonas maltophilia | 1.12% | 0% | 0.15% | 0% |
| Vibrio alginolyticus | 0% | 0% | 1.19% | 0% |
| Vibrio cholerae | 0.9% | 5.26% | 3.77% | 0% |
| Vibrio fluvialis | 2.63% | 0% | 2.67% | 0% |
| Vibrio parahaemolyticus | 0% | 0% | 0.36% | 0% |
| Vibrio vulnificus | 0% | 0% | 0.41% | 0% |
| Yersinia enterocolitica | 0% | 2.22% | 1.82% | 0% |
| Yersinia pseudotuberculosis | 0% | 0% | 1.47% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 700