tet(59)

Accession ARO:3004441
Synonym(s)tet59
DefinitionTet(59) is a chromosome-encoded tetracycline efflux pump described from a Chinese pig manure sample.
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump
Drug Classtetracycline antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification7 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_antibiotic chlortetracycline [Antibiotic]
+ confers_resistance_to_antibiotic oxytetracycline [Antibiotic]
Publications

Leclercq SO, et al. 2016. Appl. Environ. Microbiol. 82(21):6454-6462 Diversity of the Tetracycline Mobilome within a Chinese Pig Manure Sample. (PMID 27565618)

Resistomes

Prevalence of tet(59) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Providencia rettgeri100%0%76.92%
Vibrio cholerae0%0%8.07%
Vibrio parahaemolyticus1.56%0%0.99%
Vibrio vulnificus0%0%1.35%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 500

Type of Antibiotic Resistance: Intrinsic or chromosomally-encoded


>gb|AMP42492.1|+|tet(59) [uncultured bacterium IN-14]
MNKFAITALTITALDAMGIGLIMPVLPTLLREYVSAENLANHYGILLALYAIMQVFFAPLLGKWSDKFGRRPILLLSLAGAAVDYTLLAL
SSSLWMLYVGRLISGVTGATGAVAASVIADNTASQERTKWFGRLGAAFGIGLIAGPAIGGFTGQFSAHLPFIIAAILNALSFLVIMLIFK
DNKIKNTEKNTTETAENSRPFLQVIKPVILLLFIFFMTQMIGQIPATTWVLFTEHRFQWGSMEVGLSLAGLGIMHALFQAFVAGAIAKKF
NEKVTIIVGFVVDGAAFIILSLLTKGWMIYPTLILLAGGSIALPALQGLMSAQVNQTNQGKLQGVLVSLTNTTGVIGPLLFSFIFGQTLA
SWDGWIWMIGAIMYVLLIVFILSFYRSTKKIVKIAKLPAS


>gb|KU736879.1|+|22313-23515|tet(59) [uncultured bacterium IN-14]
ATGAATAAATTTGCGATCACCGCTTTAACGATCACCGCCCTAGATGCTATGGGGATCGGCTTGATCATGCCTGTATTGCCTACATTGTTA
CGTGAATACGTGTCGGCTGAAAATTTAGCAAATCATTACGGTATCCTGCTGGCACTGTATGCCATCATGCAGGTTTTTTTTGCTCCTCTA
CTTGGCAAATGGTCTGATAAATTCGGGCGCCGACCAATATTACTACTATCTCTTGCAGGCGCTGCTGTGGATTACACTTTGCTTGCATTA
TCTAGCTCACTTTGGATGCTATACGTTGGGCGATTAATTTCTGGAGTTACTGGCGCAACAGGTGCGGTCGCCGCTTCTGTTATTGCTGAC
AATACTGCTTCACAAGAGCGTACTAAGTGGTTTGGACGCTTAGGGGCGGCTTTTGGTATCGGGTTAATCGCTGGCCCTGCAATTGGCGGC
TTTACAGGGCAATTCTCAGCTCACCTTCCTTTTATTATTGCTGCCATTTTAAATGCGCTCTCTTTTTTAGTTATTATGTTGATATTTAAA
GATAATAAAATCAAAAATACTGAAAAAAACACCACAGAAACAGCAGAAAATTCGCGACCTTTCCTGCAAGTGATCAAGCCAGTCATACTA
TTGTTATTTATCTTTTTTATGACTCAAATGATAGGGCAAATTCCAGCAACGACATGGGTGTTATTTACGGAACATCGTTTTCAATGGGGC
AGTATGGAGGTCGGCCTATCTTTAGCGGGGTTAGGCATCATGCATGCCTTGTTCCAAGCATTTGTAGCGGGCGCAATCGCCAAGAAATTC
AATGAAAAAGTGACGATTATTGTGGGCTTTGTTGTTGATGGAGCAGCATTCATTATTTTGTCATTATTGACAAAGGGTTGGATGATTTAC
CCTACATTAATCTTACTCGCCGGCGGCAGTATTGCGCTACCAGCCTTACAGGGGTTAATGTCAGCTCAAGTCAATCAAACTAACCAAGGT
AAGCTACAAGGCGTTCTAGTCAGCTTAACCAATACGACGGGGGTGATCGGCCCATTATTATTTAGCTTTATTTTTGGTCAAACACTGGCA
AGTTGGGATGGCTGGATATGGATGATTGGTGCGATAATGTATGTTTTATTGATTGTATTTATTTTATCTTTTTATAGAAGCACCAAAAAG
ATAGTTAAAATAGCGAAGCTACCAGCGAGCTAA