| Accession | ARO:3000166 |
| Synonym(s) | tetB |
| CARD Short Name | tet(B) |
| Definition | Tet(B) is a tetracycline efflux protein expressed in many Gram-negative bacteria. It confers resistance to tetracycline, doxycycline, and minocycline, but not tigecycline. |
| AMR Gene Family | major facilitator superfamily (MFS) antibiotic efflux pump |
| Drug Class | tetracycline antibiotic |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Resistomes with Sequence Variants | Acinetobacter baumanniig+p+wgs+gi, Acinetobacter nosocomialiswgs, Acinetobacter radioresistenswgs, Actinobacillus indolicusg+gi, Actinobacillus pleuropneumoniaeg+wgs+gi, Actinobacillus porcitonsillarumg+gi, Avibacterium paragallinarumg+wgs+gi, Citrobacter amalonaticuswgs, Citrobacter freundiig+wgs, Citrobacter koseriwgs, Citrobacter portucalensiswgs, Citrobacter werkmaniiwgs, Cronobacter sakazakiiwgs, Enterobacter asburiaep+wgs, Enterobacter chengduensiswgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheig+p+wgs, Enterobacter kobeip+wgs, Enterobacter roggenkampiiwgs, Escherichia albertiig+wgs, Escherichia colig+p+wgs+gi, Escherichia fergusoniig+p+wgs+gi, Glaesserella parasuisg+wgs, Haemophilus influenzaeg+wgs+gi, Haemophilus parainfluenzaeg+wgs, Kingella kingaegi, Klebsiella aerogeneswgs, Klebsiella michiganensisg+p+wgs, Klebsiella oxytocawgs, Klebsiella pneumoniaeg+p+wgs+gi, Klebsiella quasipneumoniaewgs, Leclercia adecarboxylatawgs, Morganella morganiig+wgs+gi, Neisseria meningitidisg+wgs, Pasteurella multocidag+wgs+gi, Proteus columbaeg, Proteus mirabilisg+p+wgs, Proteus pennerig+wgs, Proteus vulgarisp+wgs, Providencia alcalifaciensg+wgs, Providencia rettgerig+wgs, Providencia stuartiig+wgs, Salmonella entericag+p+wgs+gi, Serratia marcescenswgs, Shigella boydiig+wgs, Shigella dysenteriaeg+p+wgs+gi, Shigella flexnerig+p+wgs+gi, Shigella sonneip+wgs, Vibrio alginolyticuswgs, Vibrio choleraep+wgs, Vibrio harveyip+wgs, Vibrio owensiig+gi, Vibrio parahaemolyticusg+p+wgs+gi, Vibrio vulnificuswgs |
| Classification | 7 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic efflux [Resistance Mechanism] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + tetracycline antibiotic [Drug Class] |
| Parent Term(s) | 2 ontology terms | Show + confers_resistance_to_antibiotic tetracycline [Antibiotic] + major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family] |
| Publications | Roberts MC. 2005. FEMS Microbiol Lett 245(2): 195-203. Update on acquired tetracycline resistance genes. (PMID 15837373) |
Prevalence of tet(B) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 40.53% | 0.99% | 34.99% | 27.04% |
| Acinetobacter nosocomialis | 0% | 0% | 1.15% | 0% |
| Acinetobacter radioresistens | 0% | 0% | 3.51% | 0% |
| Actinobacillus indolicus | 100% | 0% | 0% | 100% |
| Actinobacillus pleuropneumoniae | 16.67% | 0% | 9.52% | 100% |
| Actinobacillus porcitonsillarum | 100% | 0% | 0% | 100% |
| Avibacterium paragallinarum | 50% | 0% | 17.65% | 100% |
| Citrobacter amalonaticus | 0% | 0% | 1.82% | 0% |
| Citrobacter freundii | 0.82% | 0% | 3.68% | 0% |
| Citrobacter koseri | 0% | 0% | 1.8% | 0% |
| Citrobacter portucalensis | 0% | 0% | 0.9% | 0% |
| Citrobacter werkmanii | 0% | 0% | 7.69% | 0% |
| Cronobacter sakazakii | 0% | 0% | 0.22% | 0% |
| Enterobacter asburiae | 0% | 0.83% | 1.98% | 0% |
| Enterobacter chengduensis | 0% | 0% | 4% | 0% |
| Enterobacter cloacae | 0% | 0.56% | 3.51% | 0% |
| Enterobacter hormaechei | 1.44% | 3.6% | 6.78% | 0% |
| Enterobacter kobei | 0% | 0.69% | 1.75% | 0% |
| Enterobacter roggenkampii | 0% | 0% | 1.8% | 0% |
| Escherichia albertii | 7.14% | 0% | 4.52% | 0% |
| Escherichia coli | 4.14% | 1.72% | 10.62% | 2.81% |
| Escherichia fergusonii | 6.56% | 3.91% | 10.87% | 100% |
| Glaesserella parasuis | 38.46% | 0% | 14.36% | 0% |
| Haemophilus influenzae | 1.03% | 0% | 1.07% | 25% |
| Haemophilus parainfluenzae | 6.25% | 0% | 7.32% | 0% |
| Kingella kingae | 0% | 0% | 0% | 100% |
| Klebsiella aerogenes | 0% | 0% | 0.28% | 0% |
| Klebsiella michiganensis | 9.68% | 2.29% | 1.6% | 0% |
| Klebsiella oxytoca | 0% | 0% | 2.52% | 0% |
| Klebsiella pneumoniae | 0.24% | 0.21% | 1.87% | 0.95% |
| Klebsiella quasipneumoniae | 0% | 0% | 0.66% | 0% |
| Leclercia adecarboxylata | 0% | 0% | 4.65% | 0% |
| Morganella morganii | 46.15% | 0% | 19.63% | 23.08% |
| Neisseria meningitidis | 1.53% | 0% | 6.17% | 0% |
| Pasteurella multocida | 12.86% | 0% | 11.61% | 50% |
| Proteus columbae | 100% | 0% | 0% | 0% |
| Proteus mirabilis | 0.92% | 2.5% | 1.32% | 0% |
| Proteus penneri | 50% | 0% | 12.5% | 0% |
| Proteus vulgaris | 0% | 22.22% | 16.67% | 0% |
| Providencia alcalifaciens | 18.18% | 0% | 3.45% | 0% |
| Providencia rettgeri | 2.94% | 0% | 12.1% | 0% |
| Providencia stuartii | 75% | 0% | 59.09% | 0% |
| Salmonella enterica | 6.94% | 3.17% | 9.74% | 12.25% |
| Serratia marcescens | 0% | 0% | 0.13% | 0% |
| Shigella boydii | 6.67% | 0% | 16.67% | 0% |
| Shigella dysenteriae | 21.43% | 4.55% | 26.67% | 25% |
| Shigella flexneri | 47% | 0.8% | 67.55% | 23.81% |
| Shigella sonnei | 0% | 0.97% | 12.86% | 0% |
| Vibrio alginolyticus | 0% | 0% | 0.79% | 0% |
| Vibrio cholerae | 0% | 10.53% | 0.06% | 0% |
| Vibrio harveyi | 0% | 14.29% | 4% | 0% |
| Vibrio owensii | 8.33% | 0% | 0% | 50% |
| Vibrio parahaemolyticus | 1.62% | 1.86% | 1.34% | 100% |
| Vibrio vulnificus | 0% | 0% | 1.22% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 700