| Accession | ARO:3002703 |
| CARD Short Name | cmx |
| Definition | cmx is a plasmid or transposon-encoded chloramphenicol exporter that is found in Corynebacterium striatum and Pseudomonas aeruginosa. |
| AMR Gene Family | major facilitator superfamily (MFS) antibiotic efflux pump |
| Drug Class | phenicol antibiotic |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Resistomes with Perfect Matches | Achromobacter xylosoxidanswgs, Burkholderia cenocepaciawgs, Corynebacterium amycolatumg+wgs, Corynebacterium diphtheriaeg+wgs, Corynebacterium imitansg+gi, Corynebacterium jeikeiumwgs, Corynebacterium urealyticumg+wgs+gi, Enterobacter asburiaewgs, Glutamicibacter creatinolyticusgi, Klebsiella oxytocawgs, Klebsiella pneumoniaeg+wgs, Laribacter hongkongensiswgs, Propionibacterium freudenreichiig+gi, Proteus mirabiliswgs, Pseudomonas aeruginosag+p+wgs+gi, Pseudomonas monteiliiwgs, Pseudomonas putidawgs, Serratia marcescenswgs, Stenotrophomonas maltophiliawgs, Trueperella pyogenesg |
| Resistomes with Sequence Variants | Achromobacter xylosoxidanswgs, Burkholderia cenocepaciawgs, Corynebacterium amycolatumg+wgs, Corynebacterium diphtheriaeg+wgs, Corynebacterium imitansg+gi, Corynebacterium jeikeiumwgs, Corynebacterium urealyticumg+wgs+gi, Enterobacter asburiaewgs, Glutamicibacter creatinolyticusgi, Klebsiella oxytocawgs, Klebsiella pneumoniaeg+wgs, Laribacter hongkongensiswgs, Propionibacterium freudenreichiig+gi, Proteus mirabiliswgs, Pseudomonas aeruginosag+p+wgs+gi, Pseudomonas monteiliiwgs, Pseudomonas putidawgs, Serratia marcescenswgs, Stenotrophomonas maltophiliawgs, Trueperella pyogenesg |
| Classification | 7 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic efflux [Resistance Mechanism] + antibiotic molecule + phenicol antibiotic [Drug Class] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] |
| Parent Term(s) | 2 ontology terms | Show + confers_resistance_to_antibiotic chloramphenicol [Antibiotic] + major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family] |
| Publications | Tauch A, et al. 1998. Plasmid 40(2): 126-139. Corynebacterium striatum chloramphenicol resistance transposon Tn5564: genetic organization and transposition in Corynebacterium glutamicum. (PMID 9735314) Senda K, et al. 1996. Antimicrob. Agents Chemother. 40(2):349-53 Multifocal outbreaks of metallo-beta-lactamase-producing Pseudomonas aeruginosa resistant to broad-spectrum beta-lactams, including carbapenems. (PMID 8834878) |
Prevalence of cmx among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Achromobacter xylosoxidans | 0% | 0% | 1.53% | 0% |
| Burkholderia cenocepacia | 0% | 0% | 0.22% | 0% |
| Corynebacterium amycolatum | 57.14% | 0% | 18.52% | 0% |
| Corynebacterium diphtheriae | 3.7% | 0% | 2.51% | 0% |
| Corynebacterium imitans | 100% | 0% | 0% | 50% |
| Corynebacterium jeikeium | 0% | 0% | 10.53% | 0% |
| Corynebacterium urealyticum | 100% | 0% | 80% | 50% |
| Enterobacter asburiae | 0% | 0% | 0.4% | 0% |
| Glutamicibacter creatinolyticus | 0% | 0% | 0% | 100% |
| Klebsiella oxytoca | 0% | 0% | 0.42% | 0% |
| Klebsiella pneumoniae | 0.06% | 0% | 0.01% | 0% |
| Laribacter hongkongensis | 0% | 0% | 2.08% | 0% |
| Propionibacterium freudenreichii | 3.7% | 0% | 0% | 14.29% |
| Proteus mirabilis | 0% | 0% | 0.17% | 0% |
| Pseudomonas aeruginosa | 1.53% | 0.88% | 1.25% | 2.78% |
| Pseudomonas monteilii | 0% | 0% | 2.38% | 0% |
| Pseudomonas putida | 0% | 0% | 1.07% | 0% |
| Serratia marcescens | 0% | 0% | 0.26% | 0% |
| Stenotrophomonas maltophilia | 0% | 0% | 0.15% | 0% |
| Trueperella pyogenes | 6.67% | 0% | 0% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 700