cmlA9

Download Sequences
Accession ARO:3005043
Synonym(s)FloR2
CARD Short NamecmlA9
DefinitioncmlA9 is a Major Facilitator Superfamily efflux gene that is found in Salmonella enterica.
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump
Drug Classphenicol antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Resistomes with Perfect MatchesAcinetobacter baumanniig, Bordetella bronchisepticawgs, Burkholderia cenocepaciawgs, Burkholderia vietnamiensiswgs, Enterobacter cloacaewgs, Enterobacter hormaecheig+p+wgs, Escherichia colip+wgs, Klebsiella pneumoniaep+wgs, Laribacter hongkongensiswgs, Proteus mirabilisg+p+wgs, Providencia stuartiiwgs, Pseudomonas aeruginosap+wgs, Pseudomonas monteiliiwgs, Pseudomonas putidawgs, Salmonella entericawgs, Stenotrophomonas maltophiliawgs, Vibrio choleraeg+wgs
Resistomes with Sequence VariantsAcinetobacter baumanniig, Bordetella bronchisepticawgs, Burkholderia cenocepaciawgs, Burkholderia vietnamiensiswgs, Enterobacter cloacaewgs, Enterobacter hormaecheig+p+wgs, Escherichia colip+wgs, Klebsiella pneumoniaep+wgs, Laribacter hongkongensiswgs, Proteus mirabilisg+p+wgs, Providencia stuartiiwgs, Pseudomonas aeruginosap+wgs, Pseudomonas monteiliiwgs, Pseudomonas putidawgs, Salmonella entericawgs, Stenotrophomonas maltophiliawgs, Vibrio choleraeg+wgs
Classification7 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_antibiotic chloramphenicol [Antibiotic]
Publications

Hamidian M, et al. 2015. J. Antimicrob. Chemother. 70(2):617-9 The complete sequence of Salmonella genomic island SGI2. (PMID 25315365)
Resistomes

Prevalence of cmlA9 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GIGRDI-AMR2
Acinetobacter baumannii0.18%0%0%0%0%
Bordetella bronchiseptica0%0%2.74%0%0%
Burkholderia cenocepacia0%0%7.46%0%0%
Burkholderia vietnamiensis0%0%0.86%0%0%
Enterobacter cloacae0%0%0.32%0%0%
Enterobacter hormaechei0.36%0.06%0.22%0%0%
Escherichia coli0%0.02%0.03%0%0%
Klebsiella pneumoniae0%0.28%0.75%0%0%
Laribacter hongkongensis0%0%8.33%0%0%
Proteus mirabilis2.75%2.5%0.99%0%0%
Providencia stuartii0%0%2.27%0%0%
Pseudomonas aeruginosa0%1.17%3.89%0%0%
Pseudomonas monteilii0%0%11.9%0%0%
Pseudomonas putida0%0%2.14%0%0%
Salmonella enterica0%0%0.05%0%0%
Stenotrophomonas maltophilia0%0%0.45%0%0%
Vibrio cholerae0.45%0%1.98%0%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 750


>gb|ABZ01840.1|+|cmlA9 [Salmonella enterica subsp. enterica serovar Emek]
MTTTRPAWAYTLPAALLLMAPFDILASLAMDIYLPVVPAMPGVLNTTPSIIQLTLSLYMVMLGVGQVIFGPLSDRVGRRPILLVGATAFV
AASLGAACSSTALAFVAFRLVQAVGASAMLVATFATVRDVYANRPEGAVIYGLFSSMLAFVPALGPIAGALIGEFWGWQAIFITLAALAS
LALLNASFRWHETRPLDQARTQRSVLPIFASPAFWVYTVGFSAGMGTFFVFFSTAPRVLIGQAGYSEIGFSLAFATVALVMVTTTRFAKS
FVAKWGIAGCVARGMALLVSGAILLGIGQLFGSPSFFSFILPMWVVAVGIVFTVSVTANGALAQFDDIAGSAVAFYFCIQSLIVSIVGTL
AVTLLNGDTAWPVICYATAMAVLVSLGLALLRSRDAATEKSPVV


>gb|AY963803.6|+|24824-26038|cmlA9 [Salmonella enterica subsp. enterica serovar Emek]
ATGACCACCACACGCCCCGCGTGGGCCTATACGCTGCCGGCAGCCTTGCTGCTTATGGCTCCCTTCGACATCCTCGCCTCGCTGGCGATG
GATATTTATCTTCCAGTCGTTCCGGCGATGCCGGGCGTCCTGAACACGACTCCATCCATAATCCAACTCACGTTGAGCCTCTACATGGTG
ATGCTCGGTGTGGGCCAAGTGATCTTTGGGCCACTCTCCGATCGCGTCGGGCGACGGCCGATCCTGCTTGTAGGCGCAACGGCTTTCGTT
GCTGCGTCTCTGGGAGCGGCTTGTTCTTCAACTGCATTAGCCTTTGTTGCGTTTCGTCTGGTTCAGGCTGTTGGAGCATCGGCCATGCTG
GTGGCCACCTTCGCGACCGTGCGCGACGTATATGCCAATCGTCCCGAAGGTGCCGTCATCTACGGCCTTTTCAGTTCGATGCTGGCGTTC
GTGCCTGCGCTCGGCCCTATAGCCGGTGCGCTGATCGGCGAGTTTTGGGGATGGCAGGCGATCTTCATCACACTGGCTGCACTGGCTTCG
CTCGCACTCTTAAACGCCAGTTTCAGGTGGCATGAAACCCGACCGTTGGATCAGGCCAGAACGCAACGATCTGTTTTGCCGATCTTCGCG
AGTCCGGCCTTTTGGGTTTACACGGTCGGATTTAGTGCCGGCATGGGCACATTCTTCGTTTTCTTCTCGACAGCCCCCCGTGTTCTCATA
GGCCAAGCCGGCTATTCCGAGATCGGATTTAGCTTGGCCTTCGCGACTGTCGCGCTGGTCATGGTCACGACAACCCGCTTCGCAAAGTCC
TTCGTTGCCAAATGGGGTATCGCGGGATGCGTAGCGCGCGGGATGGCGTTGCTCGTTTCCGGCGCGATCCTGTTGGGGATCGGCCAACTT
TTCGGATCGCCGTCATTTTTCAGCTTCATCCTGCCGATGTGGGTTGTCGCGGTCGGCATTGTCTTCACGGTGTCCGTTACCGCCAACGGC
GCACTTGCGCAGTTCGACGACATCGCTGGATCAGCGGTTGCGTTCTACTTCTGCATCCAAAGCCTGATAGTCAGTATCGTCGGGACATTG
GCGGTGACGCTGTTAAACGGCGATACAGCGTGGCCCGTGATTTGTTACGCCACGGCAATGGCAGTGCTGGTGTCGTTGGGGCTGGCGCTC
CTTCGATCCCGTGATGCTGCCACCGAGAAGTCGCCAGTCGTCTAG

Curator Acknowledgements
Curator Description Most Recent Edit