lfrA

Accession ARO:3003967
DefinitionlfrA is involved in the active efflux of quinolones and is found in Mycobacteroides abscessus.
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump
Drug Classtetracycline antibiotic, isoniazid, lincosamide antibiotic, benzalkonium chloride, bicyclomycin, nitroimidazole antibiotic, nucleoside antibiotic, phenicol antibiotic, oxazolidinone antibiotic, glycylcycline, fluoroquinolone antibiotic, rifamycin antibiotic, acridine dye, antibacterial free fatty acids, peptide antibiotic, penam, diaminopyrimidine antibiotic, rhodamine, macrolide antibiotic, fosfomycin, cephalosporin
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification30 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_drug_class fluoroquinolone antibiotic [Drug Class]
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family]
Publications

Liu J, et al. 1996. J. Bacteriol. 178(13):3791-5 Active efflux of fluoroquinolones in Mycobacterium smegmatis mediated by LfrA, a multidrug efflux pump. (PMID 8682782)

Resistomes

Prevalence of lfrA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 910


>gb|AAC43550.1|+|lrfA [Mycolicibacterium smegmatis MC2 155]
MSTCIEGTPSTTRTPTRAWVALAVLALPVLLIAIDNTVLAFALPLIAEDFRPSATTQLWIVDVYSLVLAALLVAMGSLGDRLGRRRVLLI
GGAGFAVVSALAAFAPSTELLVGARALLGVFGAMLMPSTLSLIRNIFTDASARRLAIAIWASCFTAGSALGPIVGGALLEHFHWGAVFLV
AVPILLPLLVLGPRLVPESRDPNPGPFDPVSIVLSFTTMLPIVWAVKTAAHDGLSAAAAAAFAVGIVSGALFVRRQNRSATPMLDIGLFK
VMPFTSSILANFLSIIGLIGFIFFISQHLQLVLGLSPLTAGLVTLPGAVVSMIAGLAVVKAAKRFAPDTLMVTGLVFVAVGFLMILLFRH
NLTVAAIIASFVVLELGVGVSQTVSNDTIVASVPAAKSGAASAVSETAYELGAVVGTATLGTIFTAFYRSNVDVPAGLTPEQTGAAAESI
GGAAAVAADLPAATATQLLDSARAAFDSGIAPTAVIAAMLVLAAAAVVGVAFRR


>gb|U40487.1|+|171-1685|lrfA [Mycolicibacterium smegmatis MC2 155]
ATGTCCACCTGCATCGAGGGCACGCCGTCGACGACCAGGACGCCCACGCGCGCCTGGGTGGCGCTGGCCGTCCTCGCACTTCCGGTGCTG
CTCATCGCGATCGACAACACCGTGCTGGCGTTCGCGTTGCCGCTGATCGCCGAGGACTTCCGCCCGTCGGCCACCACGCAGCTGTGGATC
GTCGACGTGTACTCACTGGTGCTGGCCGCGCTGCTGGTCGCCATGGGCAGCCTCGGCGACCGACTGGGCCGCCGCAGGGTGCTGCTCATC
GGCGGGGCCGGGTTCGCGGTGGTCTCGGCGCTGGCGGCCTTCGCCCCGAGCACCGAGTTGCTGGTGGGAGCGCGCGCACTTCTCGGTGTG
TTCGGCGCGATGCTGATGCCTTCGACGCTGTCGTTGATCCGCAACATCTTCACCGACGCGTCGGCGCGGCGGTTGGCCATCGCGATCTGG
GCGTCGTGTTTCACCGCGGGTTCCGCGCTGGGCCCGATCGTCGGCGGCGCGCTGCTGGAGCATTTCCACTGGGGCGCAGTGTTCCTGGTG
GCGGTGCCGATCCTGTTGCCGCTGCTGGTCCTCGGCCCGCGTCTGGTGCCCGAATCGCGTGATCCCAATCCGGGCCCGTTCGATCCCGTG
AGCATCGTGCTGTCGTTCACGACCATGCTGCCCATCGTGTGGGCGGTCAAAACCGCGGCGCACGACGGTCTGTCGGCGGCGGCCGCGGCC
GCGTTCGCCGTGGGCATCGTCTCGGGTGCGTTGTTCGTGCGACGGCAGAACCGCAGTGCCACACCGATGCTCGACATCGGCCTGTTCAAG
GTCATGCCGTTCACGTCGTCGATCCTGGCGAACTTCCTGTCGATCATCGGCCTGATCGGGTTCATCTTCTTCATCTCGCAGCACCTTCAG
TTGGTGCTGGGCCTGTCCCCGCTCACCGCCGGCCTGGTGACGCTGCCGGGTGCCGTGGTGTCGATGATCGCGGGCCTGGCCGTGGTGAAG
GCCGCCAAGCGCTTCGCACCCGACACCCTGATGGTCACGGGCCTGGTGTTCGTGGCGGTCGGGTTCCTGATGATCCTGTTGTTCCGCCAC
AACCTCACGGTGGCCGCGATCATCGCGTCGTTCGTGGTGCTCGAGCTCGGCGTCGGCGTCTCGCAGACCGTGTCCAACGACACCATCGTG
GCGTCGGTTCCCGCCGCGAAATCCGGTGCGGCGTCCGCGGTTTCCGAGACGGCCTACGAGCTGGGCGCCGTGGTGGGGACAGCGACGCTG
GGCACGATCTTCACGGCGTTCTACCGCAGCAACGTCGACGTGCCCGCGGGGCTGACGCCCGAGCAGACCGGTGCGGCGGCCGAGAGCATC
GGCGGTGCGGCCGCGGTGGCAGCGGATCTGCCTGCCGCCACCGCCACGCAGCTTCTCGATTCGGCCCGTGCGGCGTTCGATTCGGGTATC
GCCCCGACCGCGGTGATCGCCGCGATGCTGGTGCTGGCCGCCGCCGCGGTGGTGGGTGTGGCGTTCAGGCGCTGA