cmrA

Accession ARO:3002702
DefinitioncmrA is a transposon-encoded chloramphenicol exporter that is found in Rhodococcus rhodochrous
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump
Drug Classtetracycline antibiotic, fosfomycin, nitroimidazole antibiotic, antibacterial free fatty acids, rhodamine, nucleoside antibiotic, peptide antibiotic, isoniazid, phenicol antibiotic, cephalosporin, benzalkonium chloride, fluoroquinolone antibiotic, macrolide antibiotic, lincosamide antibiotic, rifamycin antibiotic, oxazolidinone antibiotic, diaminopyrimidine antibiotic, acridine dye, glycylcycline, penam, bicyclomycin
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification30 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_antibiotic chloramphenicol [Antibiotic]
Publications

Nagy I, et al. 1997. J Bacteriol 179(14): 4635-4638. Transposition of the IS21-related element IS1415 in Rhodococcus erythropolis. (PMID 9226278)

Resistomes

Prevalence of cmrA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 500


>gb|AAC45805.1|+|cmrA [Rhodococcus rhodochrous]
MPFAIYVLGLAVFAQGTSEFMLSGLIPDMARDLGVSVPAAGLLTSAFAVGMIIGAPLMAIASMRWPRRRALLTFLITFMLVHVIGALTSS
FEVLLVTRIVGALANAGFLAVALGAAMAMVPADMKGRATSVLLGGVTIACVAGVPGGAFLGEIWGWRAAFWAVVVISAPAVVAIMFATPA
EPPAESTPNAKRELSSLRSRKLQLMLVLGALINGATFCSFTYMAPTLTDISGFDSRWIPLLLGLFGLGSFIGVSVGGRLADTRPFQLLAV
GSAALLTGWIVFALTASHPAVTLVMLFVQGALSFAVGSTLISQVLYAADAAPTLGGSFATAAFNVGAALGPALGGLAIGMGLSYRAPLWT
SAALVTLAIVIGAATLSLWRRPASVQETVPA


>gb|AF015087|+|436-1611|cmrA [Rhodococcus rhodochrous]
GTGCCTTTCGCTATCTACGTCCTCGGGCTTGCCGTCTTTGCCCAGGGCACATCCGAATTCATGTTGTCCGGGCTCATACCGGATATGGCC
CGCGACCTCGGCGTCTCGGTCCCCGCCGCCGGACTCCTCACCTCCGCCTTCGCGGTCGGGATGATCATCGGCGCTCCGCTGATGGCCATC
GCCAGCATGCGGTGGCCCCGGCGACGCGCCCTTTTGACATTCCTCATCACGTTCATGCTGGTCCACGTCATCGGCGCGCTCACCAGCAGC
TTCGAGGTCTTGCTGGTCACACGCATCGTCGGCGCCCTCGCCAACGCCGGATTCTTGGCGGTGGCCCTGGGCGCGGCGATGGCGATGGTG
CCCGCCGACATGAAAGGGCGCGCAACGTCCGTCCTCCTCGGTGGTGTCACGATCGCATGTGTAGCCGGAGTTCCCGGGGGCGCCTTCCTC
GGTGAAATATGGGGCTGGCGTGCAGCGTTCTGGGCTGTCGTCGTCATCTCCGCCCCTGCGGTGGTGGCGATCATGTTCGCCACCCCGGCC
GAGCCGCCAGCAGAGTCCACACCGAACGCCAAGCGTGAACTGTCCTCGCTGCGCTCACGCAAGCTCCAGCTGATGCTTGTCCTCGGTGCC
CTGATCAACGGCGCAACATTCTGTTCGTTCACCTACATGGCGCCCACTCTCACCGACATCTCCGGTTTCGACTCCCGTTGGATTCCGTTG
CTGCTGGGGTTGTTCGGGCTCGGATCGTTCATCGGCGTCAGCGTCGGAGGCAGGCTCGCCGATACCCGGCCGTTCCAACTTCTCGCCGTG
GGATCCGCAGCACTGTTGACGGGATGGATCGTCTTCGCTCTCACGGCATCCCACCCTGCGGTGACATTGGTGATGCTGTTCGTGCAGGGC
GCTCTGTCCTTCGCGGTCGGCTCGACCTTGATCTCCCAGGTGCTCTACGCCGCCGACGCGGCGCCGACCTTGGGTGGATCGTTCGCGACG
GCCGCGTTCAACGTCGGCGCTGCACTGGGCCCGGCCCTCGGCGGGCTGGCGATCGGTATGGGCCTGAGCTACCGCGCCCCGCTCTGGACG
AGCGCCGCGCTGGTGACTCTCGCGATCGTCATCGGCGCAGCCACCTTGTCGCTCTGGCGGCGTCCAGCGTCCGTCCAGGAAACCGTCCCA
GCCTGA