Accession | ARO:3004378 |
CARD Short Name | QepA3 |
Definition | A plasmid-mediate quinolone efflux pump described in Klebsiella aerogenes and Escherichia coli. QepA3 confers resistance to fluoroquinolone antibiotics by expelling the antibiotic molecules from the cell. This is distinct from the usual chromosomal mutation mechanism of quinolone resistance. Described by Wang et al. 2017. |
AMR Gene Family | major facilitator superfamily (MFS) antibiotic efflux pump |
Drug Class | fluoroquinolone antibiotic |
Resistance Mechanism | antibiotic efflux |
Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
Classification | 6 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic efflux [Resistance Mechanism] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + antibiotic molecule |
Parent Term(s) | 2 ontology terms | Show + major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family] + confers_resistance_to_drug_class fluoroquinolone antibiotic [Drug Class] |
Publications | Wang D, et al. 2017. J Microbiol Immunol Infect 50(2):254-257 Characterization of a novel qepA3 variant in Enterobacter aerogenes. (PMID 26947590) |
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