QepA3

Accession ARO:3004378
DefinitionA plasmid-mediate quinolone efflux pump described in Klebsiella aerogenes and Escherichia coli. QepA3 confers resistance to fluoroquinolone antibiotics by expelling the antibiotic molecules from the cell. This is distinct from the usual chromosomal mutation mechanism of quinolone resistance. Described by Wang et al. 2017.
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump
Drug Classtetracycline antibiotic, bicyclomycin, rifamycin antibiotic, lincosamide antibiotic, acridine dye, nucleoside antibiotic, nitroimidazole antibiotic, rhodamine, isoniazid, peptide antibiotic, antibacterial free fatty acids, benzalkonium chloride, glycylcycline, macrolide antibiotic, diaminopyrimidine antibiotic, oxazolidinone antibiotic, fosfomycin, phenicol antibiotic, fluoroquinolone antibiotic, penam, cephalosporin
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification30 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_drug_class fluoroquinolone antibiotic [Drug Class]
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family]
Publications

Wang D, et al. 2017. J Microbiol Immunol Infect 50(2):254-257 Characterization of a novel qepA3 variant in Enterobacter aerogenes. (PMID 26947590)

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