| Accession | ARO:3004574 |
| Synonym(s) | P0DPR4 |
| CARD Short Name | Abau_AbaQ |
| Definition | AbaQ is an MFS transporter mainly involved in the extrusion of quinolone-type drugs in A. baumannii. |
| AMR Gene Family | major facilitator superfamily (MFS) antibiotic efflux pump |
| Drug Class | fluoroquinolone antibiotic |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Resistomes with Perfect Matches | Acinetobacter baumanniig+p+wgs, Acinetobacter nosocomialisg+wgs, Acinetobacter pittiiwgs |
| Resistomes with Sequence Variants | Acinetobacter baumanniig+p+wgs, Acinetobacter calcoaceticusg+wgs, Acinetobacter indicusg, Acinetobacter lwoffiig+wgs, Acinetobacter nosocomialisg+wgs, Acinetobacter pittiig+wgs, Pseudomonas aeruginosawgs, Pseudomonas brassicacearumg+wgs, Pseudomonas chlororaphisg+wgs, Pseudomonas fluorescensg+wgs, Pseudomonas koreensisg+wgs, Pseudomonas mendocinag, Pseudomonas monteiliig+wgs, Pseudomonas putidag+wgs, Pseudomonas synxanthag+wgs, Pseudomonas syringaeg+wgs |
| Classification | 7 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic efflux [Resistance Mechanism] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + fluoroquinolone antibiotic [Drug Class] |
| Parent Term(s) | 4 ontology terms | Show + confers_resistance_to_drug_class fluoroquinolone antibiotic [Drug Class] + confers_resistance_to_antibiotic levofloxacin [Antibiotic] + major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family] + confers_resistance_to_antibiotic nalidixic acid [Antibiotic] |
| Publications | Pérez-Varela M, et al. 2018. Antimicrob. Agents Chemother. 62(9): Functional Characterization of AbaQ, a Novel Efflux Pump Mediating Quinolone Resistance in Acinetobacter baumannii. (PMID 29941648) |
Prevalence of Acinetobacter baumannii AbaQ among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 95.58% | 0.05% | 61.16% | 0% |
| Acinetobacter calcoaceticus | 100% | 0% | 21.74% | 0% |
| Acinetobacter indicus | 4.76% | 0% | 0% | 0% |
| Acinetobacter lwoffii | 9.09% | 0% | 2.63% | 0% |
| Acinetobacter nosocomialis | 90.91% | 0% | 71.26% | 0% |
| Acinetobacter pittii | 89.19% | 0% | 71.31% | 0% |
| Pseudomonas aeruginosa | 0% | 0% | 0.03% | 0% |
| Pseudomonas brassicacearum | 100% | 0% | 76% | 0% |
| Pseudomonas chlororaphis | 60.49% | 0% | 33.87% | 0% |
| Pseudomonas fluorescens | 86.11% | 0% | 49.57% | 0% |
| Pseudomonas koreensis | 100% | 0% | 91.3% | 0% |
| Pseudomonas mendocina | 12.5% | 0% | 0% | 0% |
| Pseudomonas monteilii | 100% | 0% | 47.62% | 0% |
| Pseudomonas putida | 18.31% | 0% | 22.99% | 0% |
| Pseudomonas synxantha | 100% | 0% | 87.5% | 0% |
| Pseudomonas syringae | 97.92% | 0% | 75.13% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 600