otr(B)

Accession ARO:3002892
Synonym(s)otrB tet347
Definitionotr(B) is a tetracycline resistance efflux pump found in Streptomyces rimosus
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump
Drug Classtetracycline antibiotic, acridine dye, lincosamide antibiotic, benzalkonium chloride, rifamycin antibiotic, nitroimidazole antibiotic, rhodamine, peptide antibiotic, isoniazid, fosfomycin, cephalosporin, macrolide antibiotic, nucleoside antibiotic, diaminopyrimidine antibiotic, oxazolidinone antibiotic, fluoroquinolone antibiotic, antibacterial free fatty acids, phenicol antibiotic, bicyclomycin, penam, glycylcycline
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification30 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family]
Publications

McMurry LM and Levy SB. 1998. Antimicrob Agents Chemother 42(11): 3050. Revised sequence of OtrB (tet347) tetracycline efflux protein from Streptomyces rimosus. (PMID 9867793)

Resistomes

Prevalence of otr(B) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 900


>gb|AAD04032.1|+|otr(B) [Streptomyces rimosus]
MSSANPGPAGTADQAGGAFTHRQILTAMSGLLLAVFLAALDQTVIATAMRTIADDLHGQTEQAWATTGYLIASVLAMPFYGKLSDIYGRK
PMYLISIVVFIGGSVLCGTAGSMWELALFRAVQGLGGGGLMSLPTAVVADLAPVRERGRYFAFLQMAWVVASVAGPLAGGFFAEAGQVFG
IDGWRWVFLLNVPLGLLALVTVRKALNLPHERREHRMDVLGAAALALFLVPLLIVAEQGRTWGWGSPAALALFALGAAGLAVFIPVELRR
GDEAILPLGLFRRGSIALCSAVNFTIGVGIFGTVTTLPLFLQMVQGRTPTQAGLVVIPFMLGTIASQMVSGKLIASSGRFKKLAIVGLGS
MAGALLAMATTGATTPMWGIVLIVLWLGVGIGLSQTVITSPMQNSAPKSQLGVANGASGLCRQIGGSTGIAVLFSVMFAVALGRLADLLH
TPRYERLLTDPAITGDPANHRFLDMAESGQGAGINLDDTSLLNGIDARLMQPVTDSFAHGFHIMFLAGGVVLLAGFVMTWFLRELQEETA
PEEERPAESGAGAKNGPLPASDA


>gb|AF079900|+|40-1731|otr(B) [Streptomyces rimosus]
GTGTCATCCGCAAATCCGGGCCCGGCGGGCACGGCGGACCAGGCAGGCGGGGCGTTCACGCATCGGCAGATCCTGACGGCCATGTCGGGA
CTGCTGCTGGCCGTGTTCCTCGCGGCCCTGGACCAGACGGTCATCGCCACCGCGATGCGCACCATCGCGGACGACCTCCACGGCCAGACC
GAGCAGGCATGGGCGACGACGGGCTACCTCATCGCCTCCGTCCTGGCGATGCCGTTCTACGGCAAGCTGTCCGACATCTACGGGCGCAAG
CCCATGTACCTGATCTCCATCGTGGTGTTCATCGGCGGCTCGGTGCTGTGCGGCACGGCCGGCTCGATGTGGGAGCTGGCCCTCTTCCGG
GCCGTCCAGGGACTGGGCGGCGGCGGGCTGATGTCCCTGCCCACCGCGGTGGTCGCCGACCTCGCCCCGGTGCGCGAGCGCGGCCGCTAC
TTCGCCTTCCTCCAGATGGCGTGGGTGGTCGCCAGCGTCGCGGGCCCGCTGGCGGGCGGCTTCTTCGCGGAGGCGGGCCAGGTCTTCGGC
ATCGACGGCTGGCGCTGGGTGTTCCTGCTCAACGTACCGCTGGGCCTGCTGGCCCTGGTCACCGTGCGCAAGGCCCTGAACCTGCCGCAC
GAACGGCGCGAGCACCGCATGGACGTACTGGGCGCGGCGGCGCTGGCGCTGTTCCTGGTGCCCCTGCTGATCGTCGCCGAACAGGGCCGG
ACCTGGGGCTGGGGCTCGCCGGCCGCCCTCGCCCTCTTCGCGCTCGGCGCGGCCGGGCTGGCGGTCTTCATCCCCGTCGAGCTGCGGCGC
GGCGACGAGGCCATCCTGCCGCTGGGGCTCTTCCGGCGCGGCAGCATCGCGCTGTGCTCCGCGGTCAACTTCACCATCGGCGTCGGCATC
TTCGGCACGGTCACCACCCTGCCGCTGTTCCTCCAGATGGTGCAGGGGCGGACCCCGACCCAGGCCGGACTGGTGGTCATCCCGTTCATG
CTGGGCACCATCGCCTCGCAGATGGTCTCCGGCAAGCTCATCGCGTCCTCGGGCCGGTTCAAGAAACTGGCGATCGTGGGCCTGGGCTCG
ATGGCCGGGGCGCTGCTGGCCATGGCCACCACCGGCGCGACGACCCCGATGTGGGGCATCGTCCTGATCGTCCTCTGGCTCGGCGTCGGC
ATCGGCCTGTCCCAGACCGTCATCACCTCGCCCATGCAGAACTCGGCCCCCAAGAGCCAGCTCGGCGTGGCGAACGGCGCCTCCGGCCTG
TGCCGGCAGATCGGCGGCTCCACCGGCATCGCGGTTCTGTTCTCCGTGATGTTCGCGGTGGCGCTCGGCCGCCTCGCCGACCTGCTGCAC
ACCCCGCGCTACGAGCGCCTCCTGACGGACCCGGCGATCACCGGCGACCCCGCCAACCACCGCTTCCTTGACATGGCCGAGTCCGGGCAG
GGCGCGGGGATCAACCTTGACGACACGTCCCTGCTGAACGGCATCGACGCCCGGCTGATGCAGCCGGTGACGGATTCCTTCGCCCACGGC
TTCCACATCATGTTCCTCGCCGGCGGCGTGGTGCTGCTGGCCGGGTTCGTCATGACCTGGTTCCTGCGCGAACTCCAGGAGGAGACCGCG
CCGGAGGAGGAGCGGCCGGCCGAGAGCGGCGCCGGGGCGAAGAACGGGCCGCTGCCCGCGTCGGACGCCTGA