tap

Accession ARO:3000343
CARD Short Nametap
DefinitionEfflux pump proteins contained within Mycobacterial genomes which confer resistance to a number of different antibiotics including aminoglycosides, and tetracyclines.
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump
Drug Classtetracycline antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Resistomes with Sequence VariantsMycolicibacterium fortuitumg+wgs, Mycolicibacterium septicumg+wgs
Classification7 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family]
Publications

Siddiqi N, et al. 2004. Infection 32(2): 109-111. Mycobacterium tuberculosis isolate with a distinct genomic identity overexpresses a tap-like efflux pump. (PMID 15057575)

Ainsa JA, et al. 1998. J Bacteriol 180(22): 5836-5843. Molecular cloning and characterization of Tap, a putative multidrug efflux pump present in Mycobacterium fortuitum and Mycobacterium tuberculosis. (PMID 9811639)

Resistomes

Prevalence of tap among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Mycolicibacterium fortuitum100%0%93.1%0%
Mycolicibacterium septicum100%0%100%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 700


>gb|CAA03986.1|+|tap [Mycolicibacterium fortuitum]
MTNTKRGPLLLILFAALTAGAGNGITIVAFPWLVLQHNGSALDASIVAMAGTLPLLVATLIAGAAVDYLGRRRVSMISDLLSALSVAAVP
VLALIFGVDAVNVAVLAVLAGLGAFFDPAGMTARETMLPEAAGRAGWTLDHANSVYEAVFNLGYIVGPGIGGLMIATLGGINTMWVTAGA
FCCSILAISVLRLEGAGAPDRSVLTEAVLAGIVEGLRFVWYTPVLRTLAIVDLVATGLYMPMESVLFPKYFTDRNEPTELGWVLMALSIG
GLLGALGYAVMSRYMSRRATMLTAVITLGVAMTVIAFLPPLPLILVLCAIVGFVYGPIAPIYNYVMQTTAPQHLRGRVVGVMGSLAYAAG
PLGLILAGPLADAAGLHATFLALSLPMLLLGVVAVFLPRLRELDLASKP


>gb|AJ000283.1|+|620-1849|tap [Mycolicibacterium fortuitum]
ATGACGAACACCAAGCGCGGCCCCTTGCTGCTGATCCTGTTCGCCGCGTTGACGGCCGGCGCCGGCAACGGAATCACCATCGTCGCGTTC
CCGTGGCTGGTGTTGCAGCACAACGGATCCGCGCTCGACGCCTCGATCGTCGCGATGGCCGGCACCCTGCCGCTGCTGGTGGCCACACTG
ATCGCCGGGGCGGCGGTGGATTACCTGGGTCGCCGACGGGTTTCGATGATCTCGGATCTGCTCTCGGCGCTGTCGGTCGCTGCGGTACCC
GTGCTGGCCCTGATTTTCGGGGTGGACGCGGTCAATGTCGCGGTGCTGGCGGTCCTGGCGGGGCTGGGAGCGTTCTTCGACCCGGCCGGC
ATGACAGCGCGCGAGACCATGCTGCCCGAGGCCGCGGGCCGGGCCGGTTGGACGCTGGACCATGCCAACTCGGTGTACGAGGCGGTCTTC
AACCTGGGCTACATCGTCGGCCCCGGTATCGGCGGCCTGATGATCGCCACGCTCGGCGGGATCAACACCATGTGGGTGACGGCCGGGGCG
TTCTGCTGCTCGATCCTGGCCATCTCGGTGCTGCGACTGGAGGGCGCGGGCGCGCCGGACCGCTCGGTGCTGACCGAGGCCGTTTTGGCG
GGCATAGTCGAGGGACTGCGATTCGTCTGGTACACACCGGTATTGCGCACCCTGGCCATCGTCGACCTGGTGGCCACCGGCTTGTACATG
CCGATGGAATCGGTCCTTTTTCCGAAGTACTTCACGGACCGGAACGAACCCACCGAACTGGGCTGGGTGCTGATGGCGTTGAGCATCGGC
GGACTGTTGGGTGCGCTCGGTTACGCCGTGATGTCCAGGTACATGAGCCGACGGGCCACCATGCTGACCGCCGTGATCACCCTCGGGGTG
GCGATGACGGTGATCGCCTTCCTGCCACCGCTGCCGCTGATCCTGGTGCTGTGCGCAATCGTCGGCTTCGTCTACGGACCGATCGCACCC
ATCTACAACTACGTCATGCAGACCACCGCTCCCCAACACCTGCGTGGCCGCGTGGTCGGGGTGATGGGCTCATTGGCCTACGCCGCGGGC
CCGCTCGGGCTGATCCTGGCCGGGCCGCTGGCCGACGCCGCAGGCCTGCACGCGACGTTCCTGGCACTGTCCCTACCGATGCTGTTGCTC
GGCGTCGTGGCGGTGTTCCTGCCGCGGCTGCGCGAGCTGGACCTAGCATCGAAACCGTGA