tet(33)

Accession ARO:3000478
Synonym(s)tet33 tetA(33)
DefinitionTet33 is a tetracycline efflux pump found in Gram-positive bacteria, including Arthrobacter and Corynebacterium.
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump
Drug Classtetracycline antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification7 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family]
Publications

Tauch A, et al. 2002. Plasmid 48(2): 117-129. The 27.8-kb R-plasmid pTET3 from Corynebacterium glutamicum encodes the aminoglycoside adenyltransferase gene cassette aadA9 and the regulated tetracycline efflux system Tet 33 flanked by active copies of the widespread insertion sequence IS6100. (PMID 12383729)

Resistomes

Prevalence of tet(33) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 750


>gb|CAD12227.2|+|tet(33) [Corynebacterium glutamicum]
MSSLTSARGSLATVLITASLDAAGMGLVMPILPALLHEAGVTADAVPLNVGVLIALYAVMQFIFAPVLGTLSDRFGRRRVLLVSLAGATV
DYLVLATTSALSVFYIARAVAGITGATNAVTATVIADITPPHQRAKRFGLLSACYGGGMIAGPAMGGLFGAISPHLPFLLAALLSASNLA
LTFILLRETRPDSPARSASLAQHRGRPGLSAVPGITFLLIAFGLVQFIGQAPGATWVLFTEHRLDWSPVEVGISLSVFGIVQVLVQALLT
GRIVEWIGEAKTVIIGCITDALGLVGLAIVTDAFSMAPILAALGIGGIGLPALQTLLSQRVDEQHQGRLQGVLASINSVTSIFGPVAFTT
IFALTYINADGFLWLCAAALYVPCVILIMRGTAASPKFGSWASGDSM


>gb|AJ420072.1|+|22940-24163|tet(33) [Corynebacterium glutamicum]
GTGTCATCTCTCACTTCCGCTCGTGGCTCGTTGGCCACGGTCCTCATCACGGCTAGCCTCGACGCCGCCGGCATGGGCCTGGTGATGCCG
ATTCTTCCCGCACTGCTACACGAGGCAGGGGTCACCGCTGATGCGGTTCCGCTGAACGTCGGAGTGCTGATCGCGCTCTACGCGGTAATG
CAGTTCATCTTTGCCCCCGTACTGGGAACGCTGTCGGACCGATTCGGCCGCCGCCGGGTGCTGCTTGTTTCCCTGGCCGGTGCGACCGTC
GACTATCTCGTGCTCGCCACGACGTCCGCTCTGTCGGTGTTCTATATCGCCCGCGCAGTGGCTGGGATAACCGGAGCGACCAATGCGGTC
ACCGCCACCGTGATCGCCGACATCACGCCACCCCACCAGCGCGCCAAGCGTTTCGGTTTACTCAGTGCCTGCTATGGCGGCGGAATGATC
GCGGGGCCAGCCATGGGTGGACTGTTCGGTGCCATCTCGCCACATCTGCCGTTTTTGCTCGCTGCTCTTCTCTCAGCGAGCAATCTGGCA
CTCACCTTTATCCTGTTACGCGAGACCCGTCCTGATTCCCCTGCGCGCTCTGCGTCGCTCGCTCAGCATCGTGGTCGCCCCGGCCTCAGC
GCGGTGCCTGGGATTACCTTCCTATTAATCGCATTCGGCCTTGTTCAATTCATTGGGCAGGCTCCAGGTGCGACCTGGGTGCTGTTTACT
GAACACCGCCTCGACTGGAGTCCCGTCGAAGTTGGAATCTCCCTGTCCGTTTTCGGGATCGTACAGGTTCTCGTGCAGGCCCTCCTTACT
GGCCGCATCGTGGAGTGGATCGGTGAGGCAAAAACAGTCATCATCGGGTGTATTACCGACGCCTTGGGTCTCGTAGGCCTGGCGATTGTC
ACTGACGCATTTTCCATGGCACCTATCTTGGCGGCACTGGGGATCGGTGGCATCGGCCTCCCCGCTCTGCAAACCCTTCTCTCCCAGCGC
GTCGATGAACAGCACCAAGGGCGCCTCCAGGGTGTGCTCGCCAGCATCAACAGCGTCACATCGATCTTCGGACCGGTCGCTTTCACAACG
ATCTTCGCGCTCACTTACATCAACGCCGACGGCTTCCTCTGGCTCTGCGCCGCAGCACTCTACGTGCCCTGCGTGATTCTCATCATGCGT
GGTACAGCAGCGTCCCCGAAGTTCGGCTCTTGGGCGAGCGGCGACTCGATGTGA