tet(43)

Accession ARO:3000573
Synonym(s)tet43
DefinitionTet(43) is a tetracycline resistance gene with unknown origins, isolated from metagenomic DNA.
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump
Drug Classtetracycline antibiotic, oxazolidinone antibiotic, macrolide antibiotic, benzalkonium chloride, lincosamide antibiotic, peptide antibiotic, cephalosporin, nitroimidazole antibiotic, phenicol antibiotic, nucleoside antibiotic, diaminopyrimidine antibiotic, acridine dye, penam, rifamycin antibiotic, glycylcycline, rhodamine, fluoroquinolone antibiotic, isoniazid, fosfomycin, antibacterial free fatty acids, bicyclomycin
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification30 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family]
Resistomes

Prevalence of tet(43) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 1000


>gb|ACS83748.1|-|tet(43) [uncultured bacterium AOTet43]
MPPSHHMLRPIEQCSILWNDVRYSNSVRLKEAGMTATTQASAPAARTYLSLRAAWIPLFALCLAFFVEMVDNTLLTIALPTIGRDLGASV
TSLQWVTGAYSLTFGGLLLTAGSLADRFGRRRVLQIGLLAFGLISLTVIAVATAGQLIAVRAALGLAAAAMAPITNSLVFRLFEGEDLRR
RAMTLMIVVGMSGFILGPLLGGTVLAHASWQWLLLINAPIALIALIGVRLGVPADDAEGLTKDRLDVKGSALSIAAIGLACYTLTSGVEH
GWMSAVTWACGIGAAAALMGFVWHERRTDHPMLDLDVFRNRTVRGASIAQVGTSIAMASLMFGLILHFQGAYGWSPMRAGLANLPLILTM
ILATPVSEGLAKRFGHRIAMLIGAGLLAGSLAGLAWGVGHGYLVIAVFMVTFTLGLRTVMTIAAVGLVGAMPENRTSLGAALNDTAQEVG
TSLGMAVIGTLIAVLXTTTLPNGDXSLDLATSYFAGERIAYLFLAVVVGVIAGWGALTLSNSKEMEDVH


>gb|GQ244501.1|-|60-1619|tet(43) [uncultured bacterium AOTet43]
ATGCCCCCATCTCACCACATGTTGCGCCCAATCGAACAATGTTCTATTCTATGGAACGACGTTCGATACTCGAACAGCGTTCGACTGAAG
GAGGCCGGTATGACCGCCACAACTCAAGCCTCGGCACCCGCGGCACGTACCTATCTGTCGCTGCGCGCCGCGTGGATTCCGCTCTTCGCG
CTCTGCCTCGCGTTCTTCGTGGAGATGGTTGACAACACCCTGCTCACGATCGCGCTGCCGACGATCGGGCGCGACCTCGGCGCGAGCGTC
ACCTCCTTGCAGTGGGTGACCGGCGCCTATTCGCTGACCTTTGGCGGCCTGTTGCTGACAGCGGGCTCGCTCGCCGACCGCTTTGGCCGG
CGCCGCGTGCTGCAGATTGGCCTTCTCGCCTTTGGGCTCATCAGCCTCACGGTGATTGCCGTGGCAACCGCGGGCCAGCTGATCGCGGTG
CGCGCTGCGCTCGGCCTCGCCGCCGCCGCGATGGCCCCAATCACCAACTCCCTCGTGTTCAGGCTGTTCGAGGGCGAGGACCTCCGTCGG
CGGGCAATGACCCTCATGATCGTCGTCGGCATGAGCGGATTCATCCTTGGCCCGCTACTCGGCGGAACGGTTCTCGCTCACGCCAGCTGG
CAGTGGTTGCTGCTTATCAACGCACCCATCGCGCTCATTGCGCTCATCGGCGTTCGCCTTGGCGTGCCTGCGGACGACGCCGAGGGACTC
ACAAAGGACCGCCTTGACGTGAAGGGCTCGGCACTCAGCATCGCCGCGATCGGCCTCGCTTGCTACACACTCACGAGCGGAGTGGAGCAC
GGCTGGATGTCTGCCGTCACCTGGGCCTGCGGGATCGGCGCGGCTGCCGCGCTGATGGGATTCGTGTGGCACGAGCGCCGCACCGATCAC
CCCATGCTGGACCTCGACGTCTTCAGGAACCGCACCGTTCGCGGCGCATCGATCGCCCAGGTAGGCACCTCAATCGCGATGGCTTCGCTG
ATGTTCGGCCTGATCCTTCACTTCCAGGGCGCGTACGGCTGGAGCCCCATGCGCGCCGGCCTCGCCAACCTGCCGCTCATCCTCACGATG
ATTCTTGCGACACCGGTCTCTGAGGGCCTCGCGAAGAGGTTCGGCCACCGCATTGCCATGCTCATCGGCGCGGGTCTCCTCGCCGGATCG
CTCGCTGGCCTCGCGTGGGGCGTGGGGCATGGSTACCTCGTCATCGCGGTATTCATGGTGACCTTCACCCTCGGTCTCCGCACCGTTATG
ACGATCGCGGCGGTGGGCCTCGTTGGTGCGATGCCGGAGAACCGCACCTCGCTCGGCGCGGCACTCAACGACACCGCCCAAGAAGTAGGA
ACAAGCCTCGGCATGGCAGTGATCGGCACGCTCATCGCGGTGCTCGYCACCACGACGCTTCCCAACGGCGACKGGAGCCTCGACCTCGCG
ACTTCATACTTCGCCGGGGAGCGCATCGCTTATCTGTTCCTTGCCGTCGTAGTCGGAGTGATCGCGGGATGGGGCGCGCTCACGTTGTCC
AACTCCAAGGAGATGGAAGACGTCCACTAG