norC

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Accession ARO:3007010
CARD Short NamenorC
DefinitionNorC is a multidrug efflux pump in Staphylococcus aureus that confers resistance to fluoroquinolones and other structurally unrelated antibiotics like tetracycline. It shares 61% similarity with NorB, and is a structural homolog of Blt of Bacillus subtilis. Like NorA and NorB, NorC is regulated by mgrA, also known as NorR.
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump
Drug Classdisinfecting agents and antiseptics, fluoroquinolone antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Resistomes with Perfect MatchesStaphylococcus aureusg+wgs
Resistomes with Sequence VariantsMacrococcus caniswgs, Staphylococcus aureusg+p+wgs, Staphylococcus capitisg, Staphylococcus epidermidisg+wgs, Staphylococcus equorumg+wgs, Staphylococcus haemolyticusg+wgs, Staphylococcus hominisg+wgs, Staphylococcus pasteurig+wgs, Staphylococcus saprophyticusg+wgs, Staphylococcus simulansg+wgs, Staphylococcus warneriwgs
Classification12 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Truong-Bolduc QC, et al. 2006. Antimicrob Agents Chemother 50(3): 1104-1107. NorC, a new efflux pump regulated by MgrA of Staphylococcus aureus. (PMID 16495280)

Costa MO, et al. 2013. Genome Announc 1(4): Complete Genome Sequence of a Variant of the Methicillin-Resistant Staphylococcus aureus ST239 Lineage, Strain BMB9393, Displaying Superior Ability To Accumulate ica-Independent Biofilm. (PMID 23929475)
Resistomes

Prevalence of norC among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GIGRDI-AMR2
Macrococcus canis0%0%87.5%0%0%
Staphylococcus aureus99.91%0.86%120.6%0%0%
Staphylococcus capitis10%0%0%0%0%
Staphylococcus epidermidis99.35%0%99.16%0%0%
Staphylococcus equorum83.33%0%82.14%0%0%
Staphylococcus haemolyticus68.97%0%84.4%0%0%
Staphylococcus hominis18.75%0%5.85%0%0%
Staphylococcus pasteuri50%0%57.69%0%0%
Staphylococcus saprophyticus100%0%99.3%0%0%
Staphylococcus simulans100%0%100%0%0%
Staphylococcus warneri0%0%0.82%0%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 525


>gb|AGP27106.1|+|norC [Staphylococcus aureus]
MNETYRGGNKLILGIVLGVITFWLFAQSLVNVVPNLQQSFGADMGTISIAVSLTALFSGMFVVGAGGLADKIGRVKMTNIGLLLSIIGSA
LIIITNLPALLILGRIIQGVSAACIMPSTLAIMKTYYEGAERQRALSYWSIGSWGGSGICSLFGGAVATTMGWRWIFIFSIIVAVLSMLL
IKGTPETKSEVTNTHKFDVAGLIVLVVMLLSLNVVITKGAALGYTSLWFFGLIAIVIVAFFIFLNVEKKVDNPLIDFKLFENKPYTGATI
SNFLLNGVAGTLIVANTFVQQGLGYTALQAGYLSITYLIMVLLMIRVGEKLLQKMGSKRPMLLGTFIVIIGIALISLVFLPGIFYVISCV
VGYLCFGLGLGIYATPSTDTAISNAPLDKVGVASGIYKMASSLGGAFGVAISGAVYAGAVAATSIHTGAMIALWVNVLMGIMAFIAILFA
IPNDDKRVKDAK


>gb|CP005288.1|+|116947-118335|norC [Staphylococcus aureus]
ATGAATGAAACGTATCGCGGGGGCAACAAGTTAATCTTAGGTATTGTATTAGGTGTTATTACATTTTGGTTGTTTGCACAATCACTTGTA
AATGTTGTGCCAAATTTACAACAAAGTTTTGGTGCAGACATGGGAACAATTAGTATTGCGGTAAGTCTAACCGCACTATTTTCAGGCATG
TTTGTTGTTGGAGCAGGCGGCCTAGCAGATAAAATTGGACGCGTGAAAATGACAAATATCGGCTTATTATTAAGTATTATTGGTTCAGCA
TTAATTATTATTACAAATTTACCAGCATTGCTAATTTTAGGCCGTATTATACAAGGCGTATCAGCAGCGTGTATTATGCCTTCCACATTG
GCCATTATGAAAACTTATTATGAGGGTGCTGAACGTCAGCGTGCCTTAAGCTATTGGTCTATCGGTTCTTGGGGTGGAAGTGGTATCTGT
TCACTCTTCGGTGGGGCAGTTGCGACAACTATGGGTTGGAGATGGATTTTCATCTTCTCAATCATCGTTGCCGTACTTTCAATGTTACTC
ATCAAAGGGACGCCTGAAACGAAATCAGAAGTTACCAATACACATAAATTTGACGTTGCAGGTCTAATTGTTCTAGTAGTTATGTTATTA
AGTTTAAACGTTGTCATTACTAAAGGTGCAGCACTTGGTTATACATCATTATGGTTCTTTGGTTTGATTGCAATCGTAATTGTAGCATTC
TTTATTTTCTTAAATGTTGAGAAAAAAGTAGATAATCCGCTTATTGATTTTAAATTATTTGAAAATAAACCATATACAGGTGCAACGATT
TCGAACTTCTTATTAAACGGTGTTGCAGGTACATTAATTGTAGCGAATACATTCGTACAACAAGGTTTAGGTTATACAGCATTGCAGGCA
GGATACTTATCAATCACTTATTTAATCATGGTGTTATTGATGATTAGAGTTGGTGAAAAATTATTACAAAAAATGGGTTCTAAGCGACCA
ATGTTATTAGGTACATTCATTGTGATCATTGGTATTGCACTTATTTCATTAGTATTCTTACCAGGCATATTTTATGTTATCAGTTGTGTC
GTAGGATATTTATGTTTTGGACTAGGCTTAGGTATTTATGCAACACCTTCTACAGATACAGCTATTTCAAATGCACCGTTAGATAAAGTT
GGCGTTGCTTCAGGTATTTATAAAATGGCTTCATCACTTGGTGGTGCATTCGGTGTCGCAATTAGTGGTGCAGTATATGCCGGTGCAGTT
GCTGCAACGAGCATTCATACAGGTGCGATGATTGCACTTTGGGTTAACGTATTAATGGGAATCATGGCATTTATCGCAATTTTATTTGCG
ATTCCTAATGATGATAAACGTGTCAAAGATGCGAAATAA

Curator Acknowledgements
Curator Description Most Recent Edit