tcr3

Accession ARO:3002893
Synonym(s)trcC
Definitiontcr3 is a tetracycline efflux pump that confers self-resistance to Kitasatospora aureofaciens
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump
Drug Classtetracycline antibiotic, diaminopyrimidine antibiotic, bicyclomycin, isoniazid, rifamycin antibiotic, oxazolidinone antibiotic, nitroimidazole antibiotic, macrolide antibiotic, antibacterial free fatty acids, lincosamide antibiotic, benzalkonium chloride, phenicol antibiotic, cephalosporin, fosfomycin, fluoroquinolone antibiotic, rhodamine, glycylcycline, nucleoside antibiotic, penam, peptide antibiotic, acridine dye
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification30 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family]
Publications

Dairi T, et al. 1995. Biosci Biotechnol Biochem 59(10): 1835-1841. A self-defense gene homologous to tetracycline effluxing gene essential for antibiotic production in Streptomyces aureofaciens. (PMID 8534971)

Resistomes

Prevalence of tcr3 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 950


>gb|BAA07390.1|+|tcr3 [Kitasatospora aureofaciens]
MGMANATSQTGEAVADEAGGPAGFTHRQIITALSGLLLAVLLAALDQTIVSTALRTIGDQLHGQTVQAWVITGYLVSSTIAMPFYGKLSD
IYGRKPLYLAAIAVFIVGSAACAMANSMETLAIARVLQGFGGAGLMSLPTAVIADLAPVRERGRYFSYLMMAWVAASVLGPLVGGLFAGA
GEILGVTGWRWAFLINVPLGLVALLSVRKALNLPHRRVDHPIDFRGALTLALCLVPLLIVAEEGLDWGWGSARSLTLFAVSLIGLVLFVL
AERARGLEAMVPLRLFRRGGITMATAVNFTIGVGIFGTVSTLPLFLQLVQGRSATVAGLVIIPVMTGAIVSQTICAKIIKKWNRYKKPAI
VGLGSMAGALLSLSAAGADTPLAVIVVIAAWLGFGIGLSQTVITLAIQSSAPKSELGVANAASGLFRQLGGTSGAAVFMSVLFGVAAGRL
DGADPDEAVRRALSDPGSTGGLSASAVDAFTSGFDTMFLVGGLILAVGFLLTFPLRELRDEE


>gb|D38215|+|1-1539|tcr3 [Kitasatospora aureofaciens]
ATGGGAATGGCGAACGCCACCTCGCAGACCGGCGAGGCCGTCGCGGACGAGGCCGGCGGCCCCGCCGGCTTCACTCACCGCCAGATCATC
ACCGCGCTGTCCGGGCTCCTGTTGGCCGTGCTGCTCGCCGCACTCGACCAGACGATCGTCTCCACCGCGCTGCGTACGATCGGCGACCAA
CTGCACGGCCAGACCGTCCAGGCCTGGGTGATCACCGGCTACCTGGTCAGCTCCACGATCGCGATGCCGTTCTACGGCAAGCTGTCCGAC
ATCTACGGCCGCAAGCCGCTCTATCTGGCGGCGATCGCGGTCTTCATCGTCGGCTCGGCGGCCTGCGCGATGGCGAACTCGATGGAGACG
CTGGCGATCGCCCGCGTCCTCCAGGGCTTCGGCGGCGCCGGGCTGATGTCGCTGCCGACGGCCGTCATCGCCGACCTCGCCCCGGTGCGC
GAGCGCGGGCGCTACTTCTCGTACCTGATGATGGCCTGGGTGGCGGCCAGTGTGCTCGGCCCGCTCGTCGGGGGCCTGTTCGCGGGCGCC
GGCGAGATCCTCGGGGTGACCGGCTGGCGCTGGGCCTTCCTGATCAACGTGCCGCTCGGTCTCGTGGCGCTGCTCAGCGTGCGCAAGGCG
CTCAACCTGCCGCACCGCAGGGTGGACCACCCGATCGACTTCCGGGGGGCGCTCACCCTGGCGCTCTGCCTGGTGCCGCTGCTGATCGTG
GCGGAGGAGGGCCTCGACTGGGGCTGGGGATCGGCGCGTTCGCTGACGCTGTTCGCCGTCTCGCTGATCGGCCTGGTGCTGTTCGTGCTC
GCCGAGCGGGCCCGCGGGCTGGAGGCGATGGTCCCGCTGCGGCTGTTCCGGCGCGGTGGCATCACGATGGCCACGGCCGTCAACTTCACC
ATCGGCGTCGGCATCTTCGGTACGGTCTCCACCCTGCCGCTGTTCCTGCAGCTGGTGCAGGGGCGCAGTGCCACCGTCGCCGGACTGGTG
ATCATCCCGGTGATGACCGGGGCGATCGTCTCCCAGACGATCTGCGCCAAGATCATCAAGAAGTGGAACCGCTACAAGAAGCCCGCGATC
GTGGGCCTCGGCTCGATGGCCGGAGCACTGCTGTCGCTCTCCGCCGCGGGCGCGGACACCCCGCTCGCGGTGATCGTGGTGATCGCGGCC
TGGCTGGGCTTCGGCATCGGGCTCTCCCAGACCGTCATCACCCTGGCGATCCAGAGCTCGGCGCCCAAGTCCGAGCTGGGCGTGGCCAAC
GCCGCCTCCGGGCTGTTCCGCCAGCTCGGCGGCACGAGCGGCGCCGCCGTCTTCATGTCGGTGCTGTTCGGCGTCGCCGCCGGCAGGCTC
GACGGGGCCGACCCGGACGAGGCCGTGCGCCGTGCGCTCTCCGACCCGGGCTCCACCGGCGGCCTGAGCGCCTCGGCGGTCGACGCCTTC
ACCTCGGGCTTCGACACGATGTTCCTGGTCGGCGGCCTGATCCTTGCGGTGGGCTTCCTGCTCACCTTCCCGCTGCGGGAACTGCGCGAC
GAGGAGTGA