tcr3

Accession ARO:3002893
Synonym(s)trcC
CARD Short Nametcr3
Definitiontcr3 is a tetracycline efflux pump that confers self-resistance to Kitasatospora aureofaciens.
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump
Drug Classtetracycline antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification7 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family]
Publications

Dairi T, et al. 1995. Biosci Biotechnol Biochem 59(10): 1835-1841. A self-defense gene homologous to tetracycline effluxing gene essential for antibiotic production in Streptomyces aureofaciens. (PMID 8534971)

Resistomes

Prevalence of tcr3 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 950


>gb|BAA07390.1|+|tcr3 [Kitasatospora aureofaciens]
MGMANATSQTGEAVADEAGGPAGFTHRQIITALSGLLLAVLLAALDQTIVSTALRTIGDQLHGQTVQAWVITGYLVSSTIAMPFYGKLSD
IYGRKPLYLAAIAVFIVGSAACAMANSMETLAIARVLQGFGGAGLMSLPTAVIADLAPVRERGRYFSYLMMAWVAASVLGPLVGGLFAGA
GEILGVTGWRWAFLINVPLGLVALLSVRKALNLPHRRVDHPIDFRGALTLALCLVPLLIVAEEGLDWGWGSARSLTLFAVSLIGLVLFVL
AERARGLEAMVPLRLFRRGGITMATAVNFTIGVGIFGTVSTLPLFLQLVQGRSATVAGLVIIPVMTGAIVSQTICAKIIKKWNRYKKPAI
VGLGSMAGALLSLSAAGADTPLAVIVVIAAWLGFGIGLSQTVITLAIQSSAPKSELGVANAASGLFRQLGGTSGAAVFMSVLFGVAAGRL
DGADPDEAVRRALSDPGSTGGLSASAVDAFTSGFDTMFLVGGLILAVGFLLTFPLRELRDEE


>gb|D38215.1|+|1-1539|tcr3 [Kitasatospora aureofaciens]
ATGGGAATGGCGAACGCCACCTCGCAGACCGGCGAGGCCGTCGCGGACGAGGCCGGCGGCCCCGCCGGCTTCACTCACCGCCAGATCATC
ACCGCGCTGTCCGGGCTCCTGTTGGCCGTGCTGCTCGCCGCACTCGACCAGACGATCGTCTCCACCGCGCTGCGTACGATCGGCGACCAA
CTGCACGGCCAGACCGTCCAGGCCTGGGTGATCACCGGCTACCTGGTCAGCTCCACGATCGCGATGCCGTTCTACGGCAAGCTGTCCGAC
ATCTACGGCCGCAAGCCGCTCTATCTGGCGGCGATCGCGGTCTTCATCGTCGGCTCGGCGGCCTGCGCGATGGCGAACTCGATGGAGACG
CTGGCGATCGCCCGCGTCCTCCAGGGCTTCGGCGGCGCCGGGCTGATGTCGCTGCCGACGGCCGTCATCGCCGACCTCGCCCCGGTGCGC
GAGCGCGGGCGCTACTTCTCGTACCTGATGATGGCCTGGGTGGCGGCCAGTGTGCTCGGCCCGCTCGTCGGGGGCCTGTTCGCGGGCGCC
GGCGAGATCCTCGGGGTGACCGGCTGGCGCTGGGCCTTCCTGATCAACGTGCCGCTCGGTCTCGTGGCGCTGCTCAGCGTGCGCAAGGCG
CTCAACCTGCCGCACCGCAGGGTGGACCACCCGATCGACTTCCGGGGGGCGCTCACCCTGGCGCTCTGCCTGGTGCCGCTGCTGATCGTG
GCGGAGGAGGGCCTCGACTGGGGCTGGGGATCGGCGCGTTCGCTGACGCTGTTCGCCGTCTCGCTGATCGGCCTGGTGCTGTTCGTGCTC
GCCGAGCGGGCCCGCGGGCTGGAGGCGATGGTCCCGCTGCGGCTGTTCCGGCGCGGTGGCATCACGATGGCCACGGCCGTCAACTTCACC
ATCGGCGTCGGCATCTTCGGTACGGTCTCCACCCTGCCGCTGTTCCTGCAGCTGGTGCAGGGGCGCAGTGCCACCGTCGCCGGACTGGTG
ATCATCCCGGTGATGACCGGGGCGATCGTCTCCCAGACGATCTGCGCCAAGATCATCAAGAAGTGGAACCGCTACAAGAAGCCCGCGATC
GTGGGCCTCGGCTCGATGGCCGGAGCACTGCTGTCGCTCTCCGCCGCGGGCGCGGACACCCCGCTCGCGGTGATCGTGGTGATCGCGGCC
TGGCTGGGCTTCGGCATCGGGCTCTCCCAGACCGTCATCACCCTGGCGATCCAGAGCTCGGCGCCCAAGTCCGAGCTGGGCGTGGCCAAC
GCCGCCTCCGGGCTGTTCCGCCAGCTCGGCGGCACGAGCGGCGCCGCCGTCTTCATGTCGGTGCTGTTCGGCGTCGCCGCCGGCAGGCTC
GACGGGGCCGACCCGGACGAGGCCGTGCGCCGTGCGCTCTCCGACCCGGGCTCCACCGGCGGCCTGAGCGCCTCGGCGGTCGACGCCTTC
ACCTCGGGCTTCGACACGATGTTCCTGGTCGGCGGCCTGATCCTTGCGGTGGGCTTCCTGCTCACCTTCCCGCTGCGGGAACTGCGCGAC
GAGGAGTGA