tet(41)

Accession ARO:3000569
Synonym(s)tetA(41) tet41
DefinitionTet41 is a tetracycline efflux pump found in Serratia, a Gram-negative bacterium. It is related to Acinetobacter Tet(39).
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump
Drug Classtetracycline antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification7 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family]
Publications

Thompson SA, et al. 2007. Appl Environ Microbiol 73(7): 2199-2206. Novel tetracycline resistance determinant isolated from an environmental strain of Serratia marcescens. (PMID 17308196)

Resistomes

Prevalence of tet(41) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Klebsiella oxytoca0%0%0.93%
Serratia marcescens45.95%0%27.19%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 700


>gb|AAP93922.1|-|tet(41) [Serratia marcescens]
MKKPMLVILLTVLLDAVGIGLIMPILPALLRSLGGLDAGSVHYGALLAAYALMQFLFSPILGALSDRFGRRPVLLISLAGAAADYLLMAF
APTLAWLYLGRLLAGITGANMAVATAYVTDITPVGQRARRFGLVGAVFGVGFIVGPLLGGSLGEWHLHAPFLAAAMMNALNLVMAFFLLP
ESRKSRPRAAEKIRLNPFSSLRRLHGKPGLLPLAGIYLVMALVSQAPATLWILYGQDRFGWSMMVAGLSLAGYGACHALSQAFAIGPLVA
RLGERKALLIGLAADAVGLALLSVATRGWAPFALLPFFAAGGMALPALQALMAHKVDDDHQGELQGTLASMGSLIGVAGPLVATALYAAT
RDVWPGLVWALAAALYLVVPPLLARSRARDAAP


>gb|AY264780.2|-|1825-3006|tet(41) [Serratia marcescens]
TTGAAAAAACCCATGCTGGTTATTTTGTTGACGGTGTTGCTGGATGCGGTGGGCATCGGTCTGATCATGCCTATTCTACCGGCGCTGTTG
CGCTCGCTGGGCGGTCTCGATGCCGGCAGCGTGCATTACGGCGCCCTGCTGGCGGCCTATGCGTTGATGCAATTCCTGTTTTCGCCGATC
CTCGGCGCGCTGAGCGATCGTTTCGGGCGGCGGCCGGTGCTGTTGATTTCGCTCGCCGGCGCGGCGGCCGACTACCTGCTGATGGCGTTC
GCGCCGACGCTGGCCTGGCTCTATCTGGGGCGGTTGCTGGCGGGCATCACCGGCGCCAACATGGCGGTCGCCACCGCTTACGTCACCGAT
ATTACCCCCGTCGGCCAGCGCGCTCGGCGTTTCGGCCTGGTGGGCGCGGTGTTCGGCGTCGGCTTTATCGTCGGCCCGCTGCTCGGCGGA
TCGCTGGGCGAATGGCATCTGCATGCGCCCTTCCTGGCGGCGGCGATGATGAATGCCCTCAACCTGGTGATGGCGTTTTTCCTGCTGCCC
GAATCGCGTAAATCCCGCCCCCGCGCCGCCGAGAAAATTCGCCTTAATCCCTTCTCGTCATTGCGCCGGCTGCACGGCAAGCCTGGCCTG
CTGCCGCTGGCCGGCATTTATCTGGTTATGGCGCTGGTTTCGCAGGCGCCGGCCACGCTGTGGATTTTATACGGTCAGGATCGTTTCGGC
TGGAGCATGATGGTGGCGGGCCTGTCGCTGGCCGGCTACGGCGCCTGCCACGCGCTGTCGCAGGCCTTTGCCATCGGCCCGCTGGTCGCG
CGGCTCGGCGAGCGCAAGGCGCTGCTGATCGGCCTGGCCGCCGACGCCGTGGGCCTGGCGCTGTTGTCTGTCGCCACGCGCGGCTGGGCG
CCGTTCGCCCTGCTGCCGTTCTTCGCCGCGGGCGGCATGGCGTTGCCCGCACTGCAGGCGCTGATGGCGCACAAGGTGGACGACGATCAT
CAGGGCGAGCTGCAAGGGACGCTCGCCAGCATGGGCAGCCTGATCGGCGTCGCGGGGCCGCTGGTGGCGACGGCGCTGTATGCCGCCACG
CGCGATGTCTGGCCTGGGCTGGTGTGGGCGTTGGCCGCCGCCCTGTACCTGGTGGTGCCGCCGCTGCTGGCACGCTCACGCGCCAGGGAT
GCGGCGCCATAA