tet(42)

Accession ARO:3000572
Synonym(s)tet42 tetA(42)
CARD Short Nametet(42)
DefinitionTet42 is a tetracycline efflux pump found in both Gram-negative (Pseudomonas) and Gram-positive (Microbacterium, Bacillus, Staphylococcus, Paenibacillus) bacteria.
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump
Drug Classtetracycline antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification7 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family]
Publications

Brown MG, et al. 2008. Antimicrob Agents Chemother 52(12): 4518-4521. Tet 42, a novel tetracycline resistance determinant isolated from deep terrestrial subsurface bacteria. (PMID 18809935)

Resistomes

Prevalence of tet(42) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 800


>gb|ACD35503.1|+|tet(42) [Micrococcus sp. SMCC G887]
MTSPTSLTRRDQNRAWIMLIVLTMLTVIGMTVVLPVLPFVVLQYVSHESDLAIWVGVLEAINGLCAFLVAPFLGRLSDRFGRRPVIIVAA
FGAAFSMALFGFGGALWVLVLARVIQGLTAGDLPALFAYLADITPPEQRAKRFGLLGALSGIGTMIGPAIGGLLAAISIQLPVFLTAAVA
LTIAILSIFLLPESLKPGNRITAIKLRDVQPFAVFKEAFGRKELRGLMIGFGLLALPFGFFVNNFSVLALDSIQWGPTQIGLLTAAVGII
DILIQGVLLGILLPRIGERGVIVSGIVAQMIGLAALAVVASVFAQPWVFIVGALMLAAGQGASQAAMDGAMSNAVGDDEQGWLGGATQSL
NAAMGTAAPLIAGALYALVSHAAPYWLGVALMIVAVTVVSRAHIANTAKRPAGETTGDAPAALVETAG


>gb|EU523697.1|+|687-1973|tet(42) [Micrococcus sp. SMCC G887]
ATGACTTCACCCACCTCTCTCACGCGACGGGACCAGAACCGCGCGTGGATCATGCTCATCGTGCTCACGATGCTCACCGTCATCGGAATG
ACGGTCGTCCTCCCGGTCCTGCCCTTCGTCGTGCTCCAGTACGTCTCGCACGAGAGCGACCTGGCCATCTGGGTCGGCGTGCTCGAAGCG
ATCAACGGCCTCTGCGCCTTCCTGGTCGCGCCCTTCCTCGGACGTCTCTCAGACCGCTTCGGACGTCGACCCGTGATCATCGTCGCGGCA
TTCGGTGCGGCCTTCTCGATGGCGCTGTTCGGATTCGGCGGCGCCCTCTGGGTGCTCGTGCTCGCTCGCGTCATCCAGGGCCTCACCGCG
GGCGATCTACCCGCCCTCTTCGCCTACCTGGCCGACATCACCCCGCCGGAGCAGCGCGCCAAGCGCTTCGGCCTCCTCGGTGCGCTCTCG
GGGATCGGCACCATGATCGGTCCAGCCATCGGAGGACTGCTCGCCGCGATCAGCATCCAGCTCCCGGTGTTCCTGACCGCCGCCGTCGCC
CTCACGATCGCGATCCTCAGCATCTTCCTCCTCCCGGAGAGCCTGAAGCCGGGCAACAGGATCACCGCGATCAAGCTGCGCGACGTGCAG
CCCTTCGCCGTCTTCAAGGAGGCCTTCGGACGCAAGGAGCTGCGCGGGCTGATGATCGGCTTCGGCCTGCTCGCGCTGCCGTTCGGCTTC
TTCGTGAACAACTTCAGCGTGCTCGCCCTGGACTCCATCCAGTGGGGACCGACCCAGATCGGACTCCTGACCGCGGCCGTCGGCATCATC
GACATCCTCATCCAGGGCGTGCTGCTGGGCATCCTGCTTCCGCGCATCGGCGAGCGCGGAGTGATCGTGAGCGGCATCGTCGCGCAGATG
ATCGGTCTCGCGGCCCTCGCCGTCGTGGCTTCCGTCTTCGCGCAGCCGTGGGTGTTCATCGTCGGCGCCCTGATGCTGGCCGCCGGCCAG
GGGGCGTCCCAGGCCGCGATGGACGGGGCGATGTCCAACGCCGTCGGCGACGACGAGCAGGGCTGGCTCGGCGGAGCCACCCAGTCGTTG
AATGCGGCGATGGGCACGGCAGCCCCGCTCATCGCCGGTGCGCTCTACGCACTGGTCAGCCACGCGGCCCCGTACTGGCTCGGGGTCGCG
CTCATGATCGTGGCGGTGACCGTCGTCAGCCGCGCGCACATCGCGAACACCGCGAAGCGCCCGGCCGGCGAGACGACGGGCGACGCTCCC
GCGGCACTCGTGGAGACGGCTGGCTGA