tet(42)

Accession ARO:3000572
Synonym(s)tet42 tetA(42)
DefinitionTet42 is a tetracycline efflux pump found in both Gram-negative (Pseudomonas) and Gram-positive (Microbacterium, Bacillus, Staphylococcus, Paenibacillus) bacteria.
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump
Drug Classtetracycline antibiotic, cephalosporin, phenicol antibiotic, isoniazid, macrolide antibiotic, fosfomycin, diaminopyrimidine antibiotic, rifamycin antibiotic, antibacterial free fatty acids, oxazolidinone antibiotic, peptide antibiotic, fluoroquinolone antibiotic, nitroimidazole antibiotic, benzalkonium chloride, bicyclomycin, nucleoside antibiotic, penam, glycylcycline, acridine dye, lincosamide antibiotic, rhodamine
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification30 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family]
Publications

Brown MG, et al. 2008. Antimicrob Agents Chemother 52(12): 4518-4521. Tet 42, a novel tetracycline resistance determinant isolated from deep terrestrial subsurface bacteria. (PMID 18809935)

Resistomes

Prevalence of tet(42) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 800


>gb|ACD35503.1|+|tet(42) [Micrococcus sp. SMCC G887]
MTSPTSLTRRDQNRAWIMLIVLTMLTVIGMTVVLPVLPFVVLQYVSHESDLAIWVGVLEAINGLCAFLVAPFLGRLSDRFGRRPVIIVAA
FGAAFSMALFGFGGALWVLVLARVIQGLTAGDLPALFAYLADITPPEQRAKRFGLLGALSGIGTMIGPAIGGLLAAISIQLPVFLTAAVA
LTIAILSIFLLPESLKPGNRITAIKLRDVQPFAVFKEAFGRKELRGLMIGFGLLALPFGFFVNNFSVLALDSIQWGPTQIGLLTAAVGII
DILIQGVLLGILLPRIGERGVIVSGIVAQMIGLAALAVVASVFAQPWVFIVGALMLAAGQGASQAAMDGAMSNAVGDDEQGWLGGATQSL
NAAMGTAAPLIAGALYALVSHAAPYWLGVALMIVAVTVVSRAHIANTAKRPAGETTGDAPAALVETAG


>gb|EU523697|+|687-1973|tet(42) [Micrococcus sp. SMCC G887]
ATGACTTCACCCACCTCTCTCACGCGACGGGACCAGAACCGCGCGTGGATCATGCTCATCGTGCTCACGATGCTCACCGTCATCGGAATG
ACGGTCGTCCTCCCGGTCCTGCCCTTCGTCGTGCTCCAGTACGTCTCGCACGAGAGCGACCTGGCCATCTGGGTCGGCGTGCTCGAAGCG
ATCAACGGCCTCTGCGCCTTCCTGGTCGCGCCCTTCCTCGGACGTCTCTCAGACCGCTTCGGACGTCGACCCGTGATCATCGTCGCGGCA
TTCGGTGCGGCCTTCTCGATGGCGCTGTTCGGATTCGGCGGCGCCCTCTGGGTGCTCGTGCTCGCTCGCGTCATCCAGGGCCTCACCGCG
GGCGATCTACCCGCCCTCTTCGCCTACCTGGCCGACATCACCCCGCCGGAGCAGCGCGCCAAGCGCTTCGGCCTCCTCGGTGCGCTCTCG
GGGATCGGCACCATGATCGGTCCAGCCATCGGAGGACTGCTCGCCGCGATCAGCATCCAGCTCCCGGTGTTCCTGACCGCCGCCGTCGCC
CTCACGATCGCGATCCTCAGCATCTTCCTCCTCCCGGAGAGCCTGAAGCCGGGCAACAGGATCACCGCGATCAAGCTGCGCGACGTGCAG
CCCTTCGCCGTCTTCAAGGAGGCCTTCGGACGCAAGGAGCTGCGCGGGCTGATGATCGGCTTCGGCCTGCTCGCGCTGCCGTTCGGCTTC
TTCGTGAACAACTTCAGCGTGCTCGCCCTGGACTCCATCCAGTGGGGACCGACCCAGATCGGACTCCTGACCGCGGCCGTCGGCATCATC
GACATCCTCATCCAGGGCGTGCTGCTGGGCATCCTGCTTCCGCGCATCGGCGAGCGCGGAGTGATCGTGAGCGGCATCGTCGCGCAGATG
ATCGGTCTCGCGGCCCTCGCCGTCGTGGCTTCCGTCTTCGCGCAGCCGTGGGTGTTCATCGTCGGCGCCCTGATGCTGGCCGCCGGCCAG
GGGGCGTCCCAGGCCGCGATGGACGGGGCGATGTCCAACGCCGTCGGCGACGACGAGCAGGGCTGGCTCGGCGGAGCCACCCAGTCGTTG
AATGCGGCGATGGGCACGGCAGCCCCGCTCATCGCCGGTGCGCTCTACGCACTGGTCAGCCACGCGGCCCCGTACTGGCTCGGGGTCGCG
CTCATGATCGTGGCGGTGACCGTCGTCAGCCGCGCGCACATCGCGAACACCGCGAAGCGCCCGGCCGGCGAGACGACGGGCGACGCTCCC
GCGGCACTCGTGGAGACGGCTGGCTGA