Accession ARO:3000309
CARD Short NameemrD
DefinitionEmrD is a multidrug transporter from the Major Facilitator Superfamily (MFS) primarily found in Escherichia coli. EmrD couples efflux of amphipathic compounds with proton import across the plasma membrane.
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump
Drug Classphenicol antibiotic, disinfecting agents and antiseptics
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification7 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_drug_class disinfecting agents and antiseptics [Drug Class]
+ confers_resistance_to_antibiotic chloramphenicol [Antibiotic]

Saidijam M, et al. 2006. Curr Drug Targets 7(7): 793-811. Microbial drug efflux proteins of the major facilitator superfamily. (PMID 16842212)

Paulsen IT, et al. 1996. Microbiol Rev 60(4): 575-608. Proton-dependent multidrug efflux systems. (PMID 8987357)

Naroditskaya V, et al. 1993. Biochem Biophys Res Commun 196(2): 803-809. An E. coli gene emrD is involved in adaptation to low energy shock. (PMID 8240355)

Yin Y, et al. 2006. Science 312(5774): 741-744. Structure of the multidrug transporter EmrD from Escherichia coli. (PMID 16675700)

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