| Accession | ARO:3000168 |
| Synonym(s) | tetD |
| CARD Short Name | tet(D) |
| Definition | TetD is a tetracycline efflux pump found exclusively in Gram-negative bacteria. |
| AMR Gene Family | major facilitator superfamily (MFS) antibiotic efflux pump |
| Drug Class | tetracycline antibiotic |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Resistomes with Perfect Matches | Aeromonas hydrophilag, Aeromonas veroniip+wgs, Citrobacter freundiip+wgs, Citrobacter portucalensisp+wgs, Citrobacter werkmaniiwgs, Cronobacter malonaticuswgs, Enterobacter asburiaep+wgs, Enterobacter chengduensiswgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheig+p+wgs, Enterobacter kobeip+wgs, Enterobacter roggenkampiip+wgs, Escherichia colig+p+wgs+gi, Klebsiella aerogeneswgs, Klebsiella michiganensisp+wgs, Klebsiella oxytocag+wgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaeg+p+wgs, Morganella morganiip+wgs, Plesiomonas shigelloideswgs, Proteus mirabilisg+p+gi, Proteus penneriwgs, Providencia rettgeriwgs, Raoultella planticolawgs, Salmonella entericawgs, Serratia marcescensp+wgs, Vibrio choleraep+wgs |
| Resistomes with Sequence Variants | Acinetobacter baumanniigi, Aeromonas hydrophilag, Aeromonas veroniip+wgs+gi, Bordetella trematumgi, Citrobacter freundiip+wgs, Citrobacter portucalensisp+wgs, Citrobacter werkmaniiwgs, Citrobacter youngaewgs, Comamonas testosteronigi, Corynebacterium diphtheriaegi, Cronobacter malonaticuswgs, Delftia tsuruhatensisgi, Enterobacter asburiaep+wgs, Enterobacter chengduensiswgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheig+p+wgs+gi, Enterobacter kobeip+wgs, Enterobacter roggenkampiip+wgs, Escherichia colig+p+wgs+gi, Klebsiella aerogeneswgs, Klebsiella huaxiensisg+gi, Klebsiella michiganensisp+wgs, Klebsiella oxytocag+wgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaeg+p+wgs, Laribacter hongkongensisgi, Morganella morganiig+p+wgs, Pasteurella multocidagi, Plesiomonas shigelloideswgs, Proteus mirabilisg+p+gi, Proteus penneriwgs, Providencia rettgeriwgs, Pseudomonas aeruginosagi, Raoultella planticolap+wgs, Rhodobacteraceae bacteriumgi, Salmonella entericawgs+gi, Serratia marcescensp+wgs, Shewanella putrefaciensgi, Trueperella pyogenesgi, Vibrio choleraep+wgs+gi, Vibrio neocaledonicusgi, Vibrio owensiigi |
| Classification | 7 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic efflux [Resistance Mechanism] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + tetracycline antibiotic [Drug Class] |
| Parent Term(s) | 2 ontology terms | Show + confers_resistance_to_antibiotic tetracycline [Antibiotic] + major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family] |
| Publications | Roberts MC. 2005. FEMS Microbiol Lett 245(2): 195-203. Update on acquired tetracycline resistance genes. (PMID 15837373) |
Prevalence of tet(D) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 0% | 0% | 0% | 0.63% |
| Aeromonas hydrophila | 1.54% | 0% | 0% | 0% |
| Aeromonas veronii | 0% | 3.08% | 0.56% | 25% |
| Bordetella trematum | 0% | 0% | 0% | 50% |
| Citrobacter freundii | 0% | 4% | 7.16% | 0% |
| Citrobacter portucalensis | 0% | 1.47% | 13.51% | 0% |
| Citrobacter werkmanii | 0% | 0% | 15.38% | 0% |
| Citrobacter youngae | 0% | 0% | 6.25% | 0% |
| Comamonas testosteroni | 0% | 0% | 0% | 100% |
| Corynebacterium diphtheriae | 0% | 0% | 0% | 50% |
| Cronobacter malonaticus | 0% | 0% | 1.82% | 0% |
| Delftia tsuruhatensis | 0% | 0% | 0% | 100% |
| Enterobacter asburiae | 0% | 0.55% | 1.19% | 0% |
| Enterobacter chengduensis | 0% | 0% | 12% | 0% |
| Enterobacter cloacae | 0% | 1.12% | 5.11% | 0% |
| Enterobacter hormaechei | 0.36% | 2.96% | 6.6% | 3.33% |
| Enterobacter kobei | 0% | 1.38% | 3.06% | 0% |
| Enterobacter roggenkampii | 0% | 0.97% | 1.44% | 0% |
| Escherichia coli | 0.48% | 0.01% | 0.5% | 0.64% |
| Klebsiella aerogenes | 0% | 0% | 1.98% | 0% |
| Klebsiella huaxiensis | 100% | 0% | 0% | 50% |
| Klebsiella michiganensis | 0% | 1.14% | 0.53% | 0% |
| Klebsiella oxytoca | 2.56% | 0% | 2.94% | 0% |
| Klebsiella pneumoniae | 0.24% | 1.24% | 6.61% | 0% |
| Klebsiella quasipneumoniae | 0.84% | 1.91% | 5.39% | 0% |
| Laribacter hongkongensis | 0% | 0% | 0% | 50% |
| Morganella morganii | 30.77% | 2.5% | 15.34% | 0% |
| Pasteurella multocida | 0% | 0% | 0% | 16.67% |
| Plesiomonas shigelloides | 0% | 0% | 3.45% | 0% |
| Proteus mirabilis | 0.92% | 1.25% | 0% | 7.41% |
| Proteus penneri | 0% | 0% | 12.5% | 0% |
| Providencia rettgeri | 0% | 0% | 1.91% | 0% |
| Pseudomonas aeruginosa | 0% | 0% | 0% | 9.72% |
| Raoultella planticola | 0% | 2.33% | 5.13% | 0% |
| Rhodobacteraceae bacterium | 0% | 0% | 0% | 100% |
| Salmonella enterica | 0% | 0% | 0.26% | 3.97% |
| Serratia marcescens | 0% | 2.58% | 2.49% | 0% |
| Shewanella putrefaciens | 0% | 0% | 0% | 50% |
| Trueperella pyogenes | 0% | 0% | 0% | 30% |
| Vibrio cholerae | 0% | 5.26% | 0.45% | 9.52% |
| Vibrio neocaledonicus | 0% | 0% | 0% | 100% |
| Vibrio owensii | 0% | 0% | 0% | 50% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 700