| Accession | ARO:3003196 |
| Synonym(s) | tet45 |
| CARD Short Name | tet(45) |
| Definition | Tet45 is a tetracycline efflux pump found in Bhargavaea cecembensis strain previously isolated from a poultry-litter-impacted soil. |
| AMR Gene Family | major facilitator superfamily (MFS) antibiotic efflux pump |
| Drug Class | tetracycline antibiotic |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Resistomes with Sequence Variants | Actinobacillus pleuropneumoniaewgs, Aliarcobacter butzlerig+wgs, Anaerostipes hadruswgs, Bacillus amyloliquefaciensg+wgs+gi, Bacillus anthracisg+wgs, Bacillus cereusg+p+wgs, Bacillus subtilisg+p+wgs+gi, Bacillus tequilensisg+wgs, Bacillus thuringiensisp+wgs, Bacillus velezensisg+wgs+gi, Brevibacillus laterosporuswgs, Campylobacter colig+wgs+gi, Campylobacter jejunig+p+wgs+gi, Enterococcus faecalisg+p+wgs, Enterococcus faeciumg+p+wgs+gi, Enterococcus hiraeg+p+wgs, Gardnerella vaginalisg, Klebsiella pneumoniaewgs, Lactobacillus johnsoniig+wgs, Lactococcus garvieaep+wgs, Listeria monocytogeneswgs, Megasphaera stantoniiwgs, Morganella morganiip, Providencia alcalifacienswgs, Pseudomonas aeruginosawgs, Rhizobium leguminosarumwgs, Staphylococcus arlettaewgs, Staphylococcus aureusg+p+wgs+gi, Staphylococcus capitiswgs, Staphylococcus epidermidisp+wgs, Staphylococcus haemolyticusp+wgs, Staphylococcus hominisg+p+wgs, Staphylococcus pasteurip, Staphylococcus pseudintermediuswgs, Staphylococcus saprophyticuswgs, Staphylococcus simulanswgs, Staphylococcus warnerip+wgs, Streptococcus agalactiaeg+wgs, Streptococcus anginosusg+wgs, Streptococcus gallolyticusg+p+wgs, Streptococcus lutetiensiswgs, Streptococcus pasteurianusg+wgs+gi, Streptococcus pyogenesg+wgs, Streptococcus suisg+wgs, Streptococcus uberiswgs |
| Classification | 7 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic efflux [Resistance Mechanism] + determinant of antibiotic resistance + antibiotic molecule + tetracycline antibiotic [Drug Class] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] |
| Parent Term(s) | 2 ontology terms | Show + major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family] + confers_resistance_to_antibiotic tetracycline [Antibiotic] |
| Publications | Michael GB, et al. 2011. J Antimicrob Chemother 67(1): 84-90. ICEPmu1, an integrative conjugative element (ICE) of Pasteurella multocida: analysis of the regions that comprise 12 antimicrobial resistance genes. (PMID 22001175) You Y, et al. 2013. J Antimicrob Chemother 68(9): 1962-1969. Identification of Tet45, a tetracycline efflux pump, from a poultry-litter-exposed soil isolate and persistence of tet(45) in the soil. (PMID 23595824) |
Prevalence of tet(45) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Actinobacillus pleuropneumoniae | 0% | 0% | 2.38% | 0% |
| Aliarcobacter butzleri | 12.5% | 0% | 0.81% | 0% |
| Anaerostipes hadrus | 0% | 0% | 1.72% | 0% |
| Bacillus amyloliquefaciens | 80% | 0% | 62.92% | 33.33% |
| Bacillus anthracis | 0.82% | 0% | 0.88% | 0% |
| Bacillus cereus | 1.08% | 1.82% | 18.54% | 0% |
| Bacillus subtilis | 62.72% | 0.63% | 45.95% | 5.48% |
| Bacillus tequilensis | 100% | 0% | 100% | 0% |
| Bacillus thuringiensis | 0% | 0.26% | 19.55% | 0% |
| Bacillus velezensis | 80.6% | 0% | 71.43% | 47.83% |
| Brevibacillus laterosporus | 0% | 0% | 5.88% | 0% |
| Campylobacter coli | 13.04% | 0% | 0.97% | 20% |
| Campylobacter jejuni | 3.16% | 3.96% | 0.32% | 61.54% |
| Enterococcus faecalis | 5.45% | 15.02% | 14.28% | 0% |
| Enterococcus faecium | 22.93% | 4.4% | 21.14% | 31.37% |
| Enterococcus hirae | 7.69% | 23.81% | 10.65% | 0% |
| Escherichia coli | 0% | 0% | 0% | 0% |
| Gardnerella vaginalis | 20% | 0% | 0% | 0% |
| Klebsiella pneumoniae | 0% | 0% | 0.01% | 0% |
| Lactobacillus johnsonii | 33.33% | 0% | 6.9% | 0% |
| Lactococcus garvieae | 0% | 8.33% | 4.44% | 0% |
| Listeria monocytogenes | 0% | 0% | 0.02% | 0% |
| Megasphaera stantonii | 0% | 0% | 25% | 0% |
| Morganella morganii | 0% | 2.5% | 0% | 0% |
| Providencia alcalifaciens | 0% | 0% | 3.45% | 0% |
| Pseudomonas aeruginosa | 0% | 0% | 0.01% | 0% |
| Rhizobium leguminosarum | 0% | 0% | 0.2% | 0% |
| Staphylococcus arlettae | 0% | 0% | 2.5% | 0% |
| Staphylococcus aureus | 2.27% | 3.46% | 3.15% | 1.72% |
| Staphylococcus capitis | 0% | 0% | 1.27% | 0% |
| Staphylococcus epidermidis | 0% | 0.86% | 4.1% | 0% |
| Staphylococcus haemolyticus | 0% | 1.89% | 4.4% | 0% |
| Staphylococcus hominis | 6.25% | 2.08% | 2.44% | 0% |
| Staphylococcus pasteuri | 0% | 5.88% | 0% | 0% |
| Staphylococcus pseudintermedius | 0% | 0% | 1.54% | 0% |
| Staphylococcus saprophyticus | 0% | 0% | 2.8% | 0% |
| Staphylococcus simulans | 0% | 0% | 1.69% | 0% |
| Staphylococcus warneri | 0% | 2.5% | 0.82% | 0% |
| Streptococcus agalactiae | 1.87% | 0% | 0.77% | 0% |
| Streptococcus anginosus | 17.65% | 0% | 5.85% | 0% |
| Streptococcus gallolyticus | 30% | 50% | 13.64% | 0% |
| Streptococcus lutetiensis | 0% | 0% | 10.2% | 0% |
| Streptococcus pasteurianus | 100% | 0% | 65% | 16.67% |
| Streptococcus pyogenes | 1.49% | 0% | 0.82% | 0% |
| Streptococcus suis | 1.6% | 0% | 4.51% | 0% |
| Streptococcus uberis | 0% | 0% | 2.68% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 450