Accession ARO:3007061
DefinitionHp1165 is a homolog of the Clostridium perfringes tetP gene and is part of the MFS efflux family but is not considered a true tetracycline resistance gene. Hp1165 confers low level resistance to tetracycline, however cessation of antibiotic treatment results in the host cell reverting to susceptibility.
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump
Drug Classtetracycline antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification7 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]

Li Y, et al. 2006. Arch Microbiol 185(4):255-62 Inactivation of the putative tetracycline resistance gene HP1165 in Helicobacter pylori led to loss of inducible tetracycline resistance. (PMID 16482431)