| Accession | ARO:3005010 |
| CARD Short Name | qacEdelta1 |
| Definition | QacEdelta1 is a resistance gene conferring resistance to antiseptics. It is different from QacE only at the 3'-terminus. |
| AMR Gene Family | major facilitator superfamily (MFS) antibiotic efflux pump |
| Drug Class | disinfecting agents and antiseptics |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Resistomes with Perfect Matches | Achromobacter xylosoxidansp+wgs, Acinetobacter baumanniig+p+wgs, Acinetobacter defluviip, Acinetobacter haemolyticusp, Acinetobacter indicusg+wgs, Acinetobacter johnsoniip+wgs, Acinetobacter juniip+wgs, Acinetobacter lwoffiip+wgs, Acinetobacter nosocomialiswgs, Acinetobacter pittiip+wgs, Acinetobacter radioresistenswgs, Acinetobacter townerig+wgs, Acinetobacter wuhouensisp+wgs, Aeromonas caviaep+wgs, Aeromonas hydrophilap+wgs, Aeromonas veroniig+p+wgs, Alcaligenes faecalisg+p+wgs, Burkholderia cenocepaciawgs, Burkholderia cepaciawgs, Burkholderia vietnamiensiswgs, Citrobacter amalonaticusp+wgs, Citrobacter freundiig+p+wgs, Citrobacter koserig+p+wgs, Citrobacter portucalensisp+wgs, Citrobacter werkmaniiwgs, Citrobacter youngaep+wgs, Comamonas testosteronig+p+wgs, Corynebacterium diphtheriaeg+wgs, Cronobacter malonaticuswgs, Cronobacter sakazakiip, Edwardsiella tardawgs, Enterobacter asburiaeg+p+wgs, Enterobacter chengduensiswgs, Enterobacter cloacaeg+p+wgs, Enterobacter hormaecheig+p+wgs, Enterobacter kobeig+p+wgs, Enterobacter roggenkampiip+wgs, Escherichia albertiig+p+wgs, Escherichia colig+p+wgs, Escherichia fergusoniip+wgs, Klebsiella aerogenesg+p+wgs, Klebsiella huaxiensisg, Klebsiella michiganensisg+p+wgs, Klebsiella oxytocag+p+wgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaep+wgs, Laribacter hongkongensisg+wgs, Leclercia adecarboxylatap+wgs, Morganella morganiig+wgs, Mycolicibacterium fortuitumwgs, Proteus mirabilisg+p+wgs, Proteus vulgarisp+wgs, Providencia alcalifaciensg, Providencia heimbachaep, Providencia rettgerig+p+wgs, Providencia stuartiig+p+wgs, Pseudomonas aeruginosap+wgs, Pseudomonas koreensiswgs, Pseudomonas mendocinawgs, Pseudomonas monteiliig+wgs, Pseudomonas putidag+p+wgs, Pseudomonas stutzerip+wgs, Raoultella planticolap+wgs, Salmonella entericag+p+wgs, Serratia liquefacienswgs, Serratia marcescensp+wgs, Shewanella putrefaciensp, Shigella boydiiwgs, Shigella dysenteriaep+wgs, Shigella flexnerig+p+wgs, Shigella sonneig+p+wgs, Stenotrophomonas maltophiliawgs, Trueperella pyogenesg+wgs, Vibrio alginolyticusg+p+wgs, Vibrio choleraeg+p+wgs, Vibrio fluvialisg+wgs, Vibrio harveyiwgs, Vibrio parahaemolyticusp+wgs, Vibrio vulnificuswgs, Yersinia enterocoliticawgs |
| Resistomes with Sequence Variants | Achromobacter xylosoxidansp+wgs, Acinetobacter baumanniig+p+wgs, Acinetobacter defluviip, Acinetobacter haemolyticusp, Acinetobacter indicusg+wgs, Acinetobacter johnsoniip+wgs, Acinetobacter juniip+wgs, Acinetobacter lwoffiip+wgs, Acinetobacter nosocomialiswgs, Acinetobacter pittiip+wgs, Acinetobacter radioresistenswgs, Acinetobacter townerig+wgs, Acinetobacter wuhouensisp+wgs, Aeromonas caviaep+wgs, Aeromonas hydrophilap+wgs, Aeromonas veroniig+p+wgs, Alcaligenes faecalisg+p+wgs, Burkholderia cenocepaciawgs, Burkholderia cepaciawgs, Burkholderia vietnamiensiswgs, Citrobacter amalonaticusp+wgs, Citrobacter freundiig+p+wgs, Citrobacter koserig+p+wgs, Citrobacter portucalensisp+wgs, Citrobacter werkmaniiwgs, Citrobacter youngaep+wgs, Comamonas testosteronig+p+wgs, Corynebacterium diphtheriaeg+wgs, Cronobacter malonaticuswgs, Cronobacter sakazakiip, Edwardsiella tardawgs, Enterobacter asburiaeg+p+wgs, Enterobacter chengduensiswgs, Enterobacter cloacaeg+p+wgs, Enterobacter hormaecheig+p+wgs, Enterobacter kobeig+p+wgs, Enterobacter roggenkampiip+wgs, Escherichia albertiig+p+wgs, Escherichia colig+p+wgs, Escherichia fergusoniip+wgs, Klebsiella aerogenesg+p+wgs, Klebsiella huaxiensisg, Klebsiella michiganensisg+p+wgs, Klebsiella oxytocag+p+wgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaep+wgs, Laribacter hongkongensisg+wgs, Leclercia adecarboxylatap+wgs, Morganella morganiig+wgs, Mycolicibacterium fortuitumwgs, Proteus mirabilisg+p+wgs, Proteus vulgarisp+wgs, Providencia alcalifaciensg, Providencia heimbachaep, Providencia rettgerig+p+wgs, Providencia stuartiig+p+wgs, Pseudomonas aeruginosap+wgs, Pseudomonas koreensiswgs, Pseudomonas mendocinawgs, Pseudomonas monteiliig+wgs, Pseudomonas putidag+p+wgs, Pseudomonas stutzerip+wgs, Raoultella planticolap+wgs, Salmonella entericag+p+wgs, Serratia liquefacienswgs, Serratia marcescensp+wgs, Shewanella putrefaciensp, Shigella boydiiwgs, Shigella dysenteriaep+wgs, Shigella flexnerig+p+wgs, Shigella sonneig+p+wgs, Staphylococcus haemolyticuswgs, Stenotrophomonas maltophiliawgs, Trueperella pyogenesg+wgs, Vibrio alginolyticusg+p+wgs, Vibrio choleraeg+p+wgs, Vibrio fluvialisg+wgs, Vibrio harveyiwgs, Vibrio parahaemolyticusp+wgs, Vibrio vulnificuswgs, Yersinia enterocoliticawgs |
| Classification | 6 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic efflux [Resistance Mechanism] + antibiotic molecule + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] |
| Parent Term(s) | 2 ontology terms | Show + major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family] + confers_resistance_to_drug_class disinfecting agents and antiseptics [Drug Class] |
| Publications | Kazama H, et al. 1999. FEMS Microbiol. Lett. 174(2):379-84 Characterization of the antiseptic-resistance gene qacE delta 1 isolated from clinical and environmental isolates of Vibrio parahaemolyticus and Vibrio cholerae non-O1. (PMID 10339831) |
Prevalence of qacEdelta1 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Achromobacter xylosoxidans | 0% | 14.29% | 1.53% | 0% |
| Acinetobacter baumannii | 41.24% | 2.34% | 27.68% | 0% |
| Acinetobacter defluvii | 0% | 12.5% | 0% | 0% |
| Acinetobacter haemolyticus | 0% | 2.44% | 0% | 0% |
| Acinetobacter indicus | 9.52% | 0% | 2.6% | 0% |
| Acinetobacter johnsonii | 0% | 2.78% | 5.45% | 0% |
| Acinetobacter junii | 0% | 33.33% | 4.48% | 0% |
| Acinetobacter lwoffii | 0% | 1.39% | 7.89% | 0% |
| Acinetobacter nosocomialis | 0% | 0% | 2.87% | 0% |
| Acinetobacter pittii | 0% | 3.94% | 4.55% | 0% |
| Acinetobacter radioresistens | 0% | 0% | 5.26% | 0% |
| Acinetobacter towneri | 25% | 0% | 7.69% | 0% |
| Acinetobacter wuhouensis | 0% | 4.55% | 50% | 0% |
| Aeromonas caviae | 0% | 10.39% | 56.45% | 0% |
| Aeromonas hydrophila | 0% | 3.9% | 9.68% | 0% |
| Aeromonas veronii | 12.73% | 4.62% | 10.11% | 0% |
| Alcaligenes faecalis | 15% | 20% | 23.53% | 0% |
| Burkholderia cenocepacia | 0% | 0% | 5.04% | 0% |
| Burkholderia cepacia | 0% | 0% | 6.73% | 0% |
| Burkholderia vietnamiensis | 0% | 0% | 0.86% | 0% |
| Citrobacter amalonaticus | 0% | 8.33% | 12.73% | 0% |
| Citrobacter freundii | 7.38% | 12.31% | 20.89% | 0% |
| Citrobacter koseri | 6.25% | 10% | 7.21% | 0% |
| Citrobacter portucalensis | 0% | 19.12% | 22.52% | 0% |
| Citrobacter werkmanii | 0% | 0% | 41.03% | 0% |
| Citrobacter youngae | 0% | 9.09% | 18.75% | 0% |
| Comamonas testosteroni | 20% | 50% | 7.14% | 0% |
| Corynebacterium diphtheriae | 1.85% | 0% | 1.25% | 0% |
| Cronobacter malonaticus | 0% | 0% | 1.82% | 0% |
| Cronobacter sakazakii | 0% | 5.13% | 0% | 0% |
| Edwardsiella tarda | 0% | 0% | 6.67% | 0% |
| Enterobacter asburiae | 6.45% | 1.93% | 16.6% | 0% |
| Enterobacter chengduensis | 0% | 0% | 40% | 0% |
| Enterobacter cloacae | 5.36% | 8.38% | 15.65% | 0% |
| Enterobacter hormaechei | 2.88% | 12.23% | 27.67% | 0% |
| Enterobacter kobei | 4.55% | 6.21% | 16.16% | 0% |
| Enterobacter roggenkampii | 0% | 0.97% | 12.59% | 0% |
| Escherichia albertii | 1.43% | 0.56% | 2.58% | 0% |
| Escherichia coli | 3.72% | 4.29% | 15.03% | 0% |
| Escherichia fergusonii | 0% | 2.85% | 6.52% | 0% |
| Klebsiella aerogenes | 4% | 8.7% | 4.52% | 0% |
| Klebsiella huaxiensis | 100% | 0% | 0% | 0% |
| Klebsiella michiganensis | 12.9% | 14.29% | 10.37% | 0% |
| Klebsiella oxytoca | 5.13% | 4.79% | 13.45% | 0% |
| Klebsiella pneumoniae | 18.17% | 7.63% | 28.27% | 0% |
| Klebsiella quasipneumoniae | 0% | 6.36% | 27.76% | 0% |
| Laribacter hongkongensis | 66.67% | 0% | 6.25% | 0% |
| Leclercia adecarboxylata | 0% | 9.52% | 11.63% | 0% |
| Morganella morganii | 36.54% | 0% | 19.02% | 0% |
| Mycolicibacterium fortuitum | 0% | 0% | 3.45% | 0% |
| Proteus mirabilis | 62.39% | 21.25% | 15.68% | 0% |
| Proteus vulgaris | 0% | 33.33% | 11.11% | 0% |
| Providencia alcalifaciens | 18.18% | 0% | 0% | 0% |
| Providencia heimbachae | 0% | 100% | 0% | 0% |
| Providencia rettgeri | 26.47% | 16.22% | 25.48% | 0% |
| Providencia stuartii | 12.5% | 15.91% | 20.45% | 0% |
| Pseudomonas aeruginosa | 0% | 10.53% | 11.73% | 0% |
| Pseudomonas koreensis | 0% | 0% | 4.35% | 0% |
| Pseudomonas mendocina | 0% | 0% | 14.29% | 0% |
| Pseudomonas monteilii | 22.22% | 0% | 21.43% | 0% |
| Pseudomonas putida | 4.23% | 4% | 5.88% | 0% |
| Pseudomonas stutzeri | 0% | 9.09% | 12.21% | 0% |
| Raoultella planticola | 0% | 9.3% | 7.69% | 0% |
| Salmonella enterica | 7.63% | 9.79% | 14.46% | 0% |
| Serratia liquefaciens | 0% | 0% | 3.17% | 0% |
| Serratia marcescens | 0% | 5.16% | 6.55% | 0% |
| Shewanella putrefaciens | 0% | 40% | 0% | 0% |
| Shigella boydii | 0% | 0% | 16.67% | 0% |
| Shigella dysenteriae | 0% | 9.09% | 16.67% | 0% |
| Shigella flexneri | 7% | 5.62% | 10.87% | 0% |
| Shigella sonnei | 2.44% | 2.91% | 9.13% | 0% |
| Staphylococcus haemolyticus | 0% | 0% | 0.22% | 0% |
| Stenotrophomonas maltophilia | 0% | 0% | 0.45% | 0% |
| Trueperella pyogenes | 26.67% | 0% | 8.33% | 0% |
| Vibrio alginolyticus | 1.23% | 3.57% | 0.4% | 0% |
| Vibrio cholerae | 1.79% | 21.05% | 5.11% | 0% |
| Vibrio fluvialis | 2.63% | 0% | 4% | 0% |
| Vibrio harveyi | 0% | 0% | 4% | 0% |
| Vibrio parahaemolyticus | 0% | 0.62% | 0.21% | 0% |
| Vibrio vulnificus | 0% | 0% | 0.41% | 0% |
| Yersinia enterocolitica | 0% | 0% | 0.91% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 190