cmlA8

Accession ARO:3004665
DefinitioncmlA8 is a plasmid that confers resistance to chloramphenicol.
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump
Drug Classtetracycline antibiotic, macrolide antibiotic, acridine dye, oxazolidinone antibiotic, benzalkonium chloride, nucleoside antibiotic, bicyclomycin, fluoroquinolone antibiotic, nitroimidazole antibiotic, phenicol antibiotic, diaminopyrimidine antibiotic, peptide antibiotic, isoniazid, rifamycin antibiotic, glycylcycline, fosfomycin, antibacterial free fatty acids, penam, lincosamide antibiotic, cephalosporin, rhodamine
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification30 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_antibiotic chloramphenicol [Antibiotic]
Publications

Wu Y, et al. 2008. J. Microbiol. 46(6):687-91 Detection of Pseudomonas aeruginosa carried a new array of gene cassettes within class 1 integron isolated from a teaching hospital in Nanjing, China. (PMID 19107398)

Resistomes

Prevalence of cmlA8 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Pseudomonas putida0%0%1.25%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 815


>gb|ABW91179.1|+|cmlA8 [Pseudomonas aeruginosa]
MRSKNFSWRYSLAATVLLLSPFDLLASLGMDMYLPAVPFMPNALGTTTSTIQLTLTTYLVMIGAGQLLFGPLSDRLGRRPVLLGGGLAYV
VASMGLALTSSAEVFLGLRILQACGASACLVSTFATVRDIYAGREESNVIYGILGSMLAMVPAIGPLLGALVDTWLGWRAIFAFLGLGMI
AASAAAWRFWPETRVQRVAGLQWSQLLLPIKCLNFWLYTLCYTAGMGSFFVFFSIAPGLMMGRQGVSQLDFSLLFATVAIAMVFTARFMG
RVIPKWGSPSVLRMGMGCLIAGAVLLAITEIWVSQSVLGFIAPMWLVGVGVATAVSVAPNGALRGFDHVAGTVTAVYFCLGGVLLGSIGT
LIIWLLPRNTAWPVVVYCLTLATVVLGLSCVSRAKGFRGQREHDVVALQNAESTSNPNR


>gb|EU182575.1|+|1686-2945|cmlA8 [Pseudomonas aeruginosa]
GTGCGCTCAAAGAACTTTAGTTGGCGGTACTCCCTTGCCGCCACGGTGTTGTTGTTATCACCGTTCGATTTACTGGCATCACTCGGCATG
GATATGTACTTGCCGGCAGTGCCCTTCATGCCAAACGCACTTGGCACGACAACGAGTACAATTCAGCTTACGCTGACAACGTACTTGGTC
ATGATCGGTGCCGGTCAGCTCTTGTTTGGACCACTATCGGACCGACTAGGTCGCCGCCCCGTTCTATTGGGGGGTGGCCTCGCCTACGTT
GTGGCGTCAATGGGCCTCGCTCTTACGTCGTCGGCTGAAGTCTTTCTGGGGCTTCGGATTCTTCAGGCTTGTGGTGCCTCGGCGTGCCTT
GTTTCCACGTTTGCAACAGTACGTGACATTTACGCAGGTCGTGAGGAAAGTAACGTCATTTACGGCATACTCGGGTCCATGCTGGCCATG
GTCCCGGCGATAGGCCCATTGCTGGGAGCACTCGTCGACACGTGGCTTGGGTGGCGGGCTATCTTTGCGTTTCTAGGTTTGGGCATGATC
GCTGCATCTGCAGCAGCGTGGCGATTCTGGCCTGAAACCCGGGTGCAACGAGTTGCGGGCTTGCAATGGTCGCAGCTGCTACTCCCCATT
AAGTGCCTGAACTTCTGGTTGTACACGTTGTGTTACACCGCTGGAATGGGTAGCTTTTTCGTCTTTTTCTCCATTGCGCCCGGGCTAATG
ATGGGCAGGCAAGGTGTGTCTCAGCTTGACTTCAGCCTGCTGTTCGCCACAGTGGCAATCGCCATGGTGTTTACGGCTCGTTTTATGGGG
CGAGTGATACCCAAGTGGGGAAGTCCAAGTGTCTTGCGAATGGGAATGGGATGCCTGATAGCGGGAGCAGTATTGCTTGCCATCACCGAA
ATATGGGTTTCGCAGTCCGTGTTGGGCTTTATTGCTCCAATGTGGCTAGTGGGTGTTGGTGTCGCCACAGCGGTATCTGTGGCGCCCAAT
GGCGCTCTTCGAGGATTCGACCACGTTGCCGGAACGGTCACGGCAGTCTACTTCTGCTTGGGCGGTGTACTGCTAGGAAGCATCGGAACG
TTGATCATTTGGCTGTTGCCGCGCAACACGGCTTGGCCGGTTGTCGTGTACTGTTTGACCCTTGCAACAGTCGTGCTTGGTCTGTCTTGT
GTTTCCCGAGCGAAGGGCTTTCGCGGCCAGAGGGAGCATGATGTGGTCGCGCTACAAAATGCGGAAAGTACGTCAAATCCCAATCGCTGA