tet(G)

Accession ARO:3000174
Synonym(s)tetG
DefinitionTetG is a tetracycline efflux protein found in Gram-negative bacteria. The encoding gene is found in both chromosomal and plasmid DNA where it is frequently linked to the floR, sul1, and cmlA9 genes which encode proteins that can confer florfenicol/chloramphenicol, sulfamethoxazole, and chloramphenicol resistance, respectively.
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump
Drug Classtetracycline antibiotic, macrolide antibiotic, benzalkonium chloride, nitroimidazole antibiotic, bicyclomycin, antibacterial free fatty acids, phenicol antibiotic, cephalosporin, rifamycin antibiotic, nucleoside antibiotic, fluoroquinolone antibiotic, diaminopyrimidine antibiotic, peptide antibiotic, acridine dye, glycylcycline, lincosamide antibiotic, fosfomycin, rhodamine, isoniazid, oxazolidinone antibiotic, penam
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification30 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family]
Publications

Roberts MC. 2005. FEMS Microbiol Lett 245(2): 195-203. Update on acquired tetracycline resistance genes. (PMID 15837373)

Resistomes

Prevalence of tet(G) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 730


>gb|AAD25538.1|+|tet(G) [Pseudomonas sp.]
MRSSAIIALLIVGLDAIGLGLIMPVLPTLLRELVPAEQVAGHYGALLSLYALMQVVCAPLLGQFSDGYGRRPVLLASLAGAAVDYTIMAS
APVLWVLYIGRLISGITGATGAVAASTIADSTGEGSRARWFGYMGACYGTGMIAGPALGGMLGGISAHAPFIAAALLNGFAFLLACIFLK
ETNRSHGETGKLVRIEPFVLFRLDDALRGLTALFAVFFTIQLIGQVPAALWVIYGEDRFQWDTTTVGLSLAAFGATHAIFQAFVTGPLSS
RLGERRTLLFGMAADATGFILLAFATQGWMVFPILLLLAAGGVGMPALQAMLSNNVSSNKQGALQGTLTSLTNLSSIAGPLGFTALYSAT
IGAWTGWVWIVGAILYLICLPILRRPFATSL


>gb|AF133139|+|1-1176|tet(G) [Pseudomonas sp.]
GTGCGCAGCTCTGCCATCATTGCCCTGCTGATCGTCGGTCTCGACGCCATAGGACTCGGCCTCATAATGCCGGTCCTTCCGACGCTTCTG
CGCGAGCTTGTGCCGGCAGAGCAGGTCGCTGGTCACTATGGTGCTTTGCTGTCGCTCTATGCGTTGATGCAGGTCGTCTGCGCCCCTCTA
CTTGGGCAATTTTCAGATGGTTACGGTCGGCGTCCGGTGCTTCTGGCTTCTCTTGCGGGGGCCGCAGTCGATTACACGATTATGGCATCA
GCGCCGGTCTTATGGGTGCTGTATATTGGCCGGCTCATTTCTGGCATCACGGGAGCAACCGGAGCTGTAGCTGCCTCAACCATTGCCGAT
TCGACAGGGGAAGGGTCTCGCGCACGCTGGTTCGGCTACATGGGAGCCTGTTATGGGACAGGCATGATTGCCGGGCCAGCACTTGGTGGC
ATGCTCGGTGGTATTTCTGCTCATGCTCCGTTTATCGCCGCTGCCCTTCTAAACGGCTTCGCGTTCCTGCTTGCCTGCATTTTTCTCAAG
GAGACTAATCGCAGCCATGGCGAGACCGGAAAACTGGTCCGCATCGAACCATTCGTTCTGTTCCGGCTGGATGATGCATTGCGTGGACTA
ACCGCGCTTTTCGCAGTTTTCTTCACTATTCAACTGATCGGCCAAGTGCCTGCGGCCCTATGGGTCATATATGGCGAGGACCGTTTTCAG
TGGGACACCACGACCGTTGGTTTGTCGCTCGCGGCGTTTGGAGCAACACATGCGATCTTCCAAGCGTTTGTTACCGGCCCTCTTTCAAGC
CGGCTTGGAGAGCGGCGCACATTACTGTTTGGCATGGCTGCGGATGCGACTGGCTTCATTCTTCTAGCTTTTGCCACGCAGGGATGGATG
GTGTTCCCGATTCTGCTGCTGCTTGCCGCCGGGGGCGTTGGCATGCCGGCCTTGCAGGCAATGCTCTCAAACAATGTCAGCAGTAACAAG
CAAGGAGCTCTACAGGGAACGCTTACAAGCCTCACCAATCTAAGCTCTATCGCGGGACCGCTTGGCTTCACGGCACTCTATTCTGCCACC
ATAGGAGCATGGACCGGTTGGGTTTGGATTGTCGGCGCGATCCTCTATTTAATATGTCTGCCAATACTACGCAGACCTTTCGCAACTTCA
TTGTGA