tetA(P)

Accession ARO:3000180
Synonym(s)tetP
CARD Short NametetA(P)
DefinitionTetA(P) is a inner membrane tetracycline efflux protein found on the same operon as the ribosomal protection protein TetB(P). It is found in Clostridium, a Gram-positive bacterium.
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump
Drug Classtetracycline antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Resistomes with Perfect MatchesClostridium perfringenswgs
Resistomes with Sequence VariantsClostridium perfringenswgs, Jeotgalibaca arthritidisgi
Classification7 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family]
Publications

Bannam TL, et al. 2004. Microbiology 150(PT 1): 127-134. The Clostridium perfringens TetA(P) efflux protein contains a functional variant of the Motif A region found in major facilitator superfamily transport proteins. (PMID 14702405)

Roberts MC. 2005. FEMS Microbiol Lett 245(2): 195-203. Update on acquired tetracycline resistance genes. (PMID 15837373)

Resistomes

Prevalence of tetA(P) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Clostridium perfringens0%0%0.24%0%
Jeotgalibaca arthritidis0%0%0%33.33%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 800


>gb|AAA20116.1|+|tetA(P) [Clostridium perfringens]
MVNKLSAYKTYLLFSAITAMCFSLVATVMMVYHIEIVHLNPLQLILVGTTLELACFIFEIPTAIVADVYSRKLSIVIGGVLTGVGFILEG
SISSFVFVLVAQIVWGLGSTFISGSLEAWIAEEEKNKDLDEIYIKGAQAGQIGAFIGIVLSTVIANFSVRLPIIVSGVLFIILALFLWLY
MPENNFKPSAPGDLNTFKKMVYTFKSGLKFVKSKSIIMILLAVTLFYGLSSEGYDRLSNAHFLQDTTLPKLGNLSSVTWFGIFGILGMIL
SFIVMHFMAKNLKNEDNRKNGKLLLCINILYISSMLIFALTRNFSLMLIAYLATNTFRIINKPIFSAWLNGHIDDNSRATVLSINGQMNS
LGQILGGPIIGIIATNISVSIGIVCTSLLVTPVLVLYIVAMIIDKKVDDRVGGIDYEENN


>gb|L20800.1|+|1063-2325|tetA(P) [Clostridium perfringens]
ATGGTTAATAAACTTTCAGCATATAAAACTTATTTATTATTTTCAGCTATTACAGCAATGTGTTTTTCGTTAGTAGCTACAGTTATGATG
GTGTATCACATTGAAATAGTTCATTTAAATCCACTTCAGCTTATACTTGTTGGAACTACTTTGGAATTAGCATGCTTTATATTTGAAATT
CCTACAGCTATAGTTGCAGATGTGTATAGTCGTAAACTATCTATTGTTATTGGGGGAGTTTTAACAGGAGTGGGATTTATTTTAGAAGGT
TCTATTTCTAGTTTTGTTTTCGTACTTGTAGCACAGATTGTATGGGGATTAGGGTCTACTTTTATCAGTGGCTCGCTTGAAGCTTGGATT
GCGGAAGAAGAGAAGAATAAAGATTTAGATGAAATTTATATAAAGGGAGCACAAGCAGGGCAGATAGGAGCATTTATTGGAATAGTACTA
AGCACTGTAATAGCTAATTTCTCTGTAAGGCTTCCTATTATAGTTAGTGGAGTTTTATTTATAATTCTTGCATTATTTTTATGGTTATAT
ATGCCAGAAAATAATTTTAAACCATCTGCTCCTGGGGATTTAAATACATTCAAAAAGATGGTATATACATTTAAATCTGGTCTTAAATTT
GTAAAAAGTAAATCTATAATTATGATTTTACTTGCAGTAACTTTATTTTATGGATTATCAAGTGAAGGTTATGATAGACTTTCTAATGCG
CATTTTTTACAAGATACTACACTTCCTAAACTTGGAAACCTTAGTTCAGTGACTTGGTTTGGAATTTTTGGAATTTTAGGAATGATATTG
AGCTTCATAGTAATGCATTTTATGGCAAAGAATCTTAAGAATGAGGATAATAGGAAAAATGGAAAACTATTATTATGCATAAATATACTT
TATATATCGTCTATGTTGATATTTGCTCTTACAAGAAACTTTAGTTTAATGTTAATAGCTTATTTGGCAACAAATACCTTTAGAATTATA
AATAAACCTATATTCAGTGCGTGGTTAAATGGGCATATAGATGATAATTCTAGAGCTACTGTGCTTTCTATAAATGGACAAATGAATTCC
TTAGGTCAAATTTTAGGTGGACCGATTATAGGAATCATAGCTACAAATATTTCAGTAAGTATTGGTATAGTATGTACTTCGTTATTAGTA
ACACCGGTATTAGTGTTATATATTGTTGCTATGATAATTGATAAAAAGGTGGATGATAGAGTTGGAGGTATTGATTATGAAGAAAATAAT
TAA