farAB

Accession ARO:3003960
DefinitionfarAB is an MFS efflux pump found in gonococci that is involved in antibacterial fatty acid resistance. Moreover, expression of the tandemly linked farA and farB genes was positively associated with the presence of the MtrR transcriptional regulatory protein that normally downregulates the expression of mtrCDE.
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump
Drug Classtetracycline antibiotic, nitroimidazole antibiotic, diaminopyrimidine antibiotic, antibacterial free fatty acids, macrolide antibiotic, phenicol antibiotic, rifamycin antibiotic, isoniazid, fluoroquinolone antibiotic, glycylcycline, cephalosporin, fosfomycin, acridine dye, nucleoside antibiotic, benzalkonium chloride, lincosamide antibiotic, rhodamine, penam, bicyclomycin, oxazolidinone antibiotic, peptide antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification30 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_antibiotic palmitic acid [Antibiotic]
+ confers_resistance_to_antibiotic oleic acid [Antibiotic]
+ confers_resistance_to_antibiotic linoleic acid [Antibiotic]
Sub-Term(s)
3 ontology terms | Show
+ farA part_of
+ farB part_of
+ mtrR regulates
Publications

Lee EH, et al. 1999. Mol. Microbiol. 33(4):839-45 The farAB-encoded efflux pump mediates resistance of gonococci to long-chained antibacterial fatty acids. (PMID 10447892)