farA

Accession ARO:3003961
DefinitionfarA is the membrane fusion protein that is part of the farAB efflux pump.
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump
Drug Classtetracycline antibiotic, oxazolidinone antibiotic, phenicol antibiotic, acridine dye, antibacterial free fatty acids, fosfomycin, peptide antibiotic, nucleoside antibiotic, fluoroquinolone antibiotic, isoniazid, glycylcycline, rifamycin antibiotic, diaminopyrimidine antibiotic, bicyclomycin, penam, rhodamine, benzalkonium chloride, nitroimidazole antibiotic, lincosamide antibiotic, macrolide antibiotic, cephalosporin
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
ResistomesNeisseria meningitidisg+wgs
Classification34 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Lee EH, et al. 1999. Mol. Microbiol. 33(4):839-45 The farAB-encoded efflux pump mediates resistance of gonococci to long-chained antibacterial fatty acids. (PMID 10447892)

Resistomes

Prevalence of farA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Neisseria gonorrhoeae100%0%99.83%
Neisseria meningitidis100%0%97.85%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 730


>gb|AAF40763.1|+|farA [Neisseria meningitidis MC58]
MDTHTDETKLQNTQAKRKRRLTALTLLFALAAAAAGSAFFLWWQHEEETEDAYVAGRVVQVTPQKGGTVRKVLHDDTDAVKKGDVLAVLD
DDNDVLAYERAKNELVQAVRQNRRQNAATSQAGAQVALRRADLARAQDDLRRRSALAESGAVSAEELAHARAAVSQAQAAVKAALAEESS
ARAALGGQVSLREQPAVQTAIGRLKDAWLNLQRTQIRAPADGQVAKRSVQVGQQVAAGAPLMAVVPLSDVWVDANFKETQLRHMKIGQPA
ELVSDLYGKQIVYRGRVAGFSAGTGSAFSLIPAQNATGNWIKVVQRVPVRIVLNREDVDRHPLRIGLSMTVKVDTSAAGAPVSKTPGAAL
PEMESTDWSEVDRTVDEILGQSAP


>gb|AE002098.2|+|329613-330767|farA [Neisseria meningitidis MC58]
ATGGATACGCACACGGACGAAACAAAACTTCAAAACACGCAAGCCAAACGCAAACGCCGCCTGACGGCATTGACGCTGCTGTTCGCGCTT
GCCGCCGCAGCCGCCGGGTCGGCGTTTTTTTTATGGTGGCAGCACGAAGAGGAAACGGAAGACGCTTATGTTGCCGGACGCGTGGTTCAG
GTTACGCCGCAAAAGGGCGGTACGGTGCGGAAGGTTTTGCACGACGATACGGATGCCGTGAAAAAAGGCGACGTGCTGGCGGTATTGGAC
GACGATAATGATGTGCTGGCTTACGAGCGGGCAAAAAACGAGCTGGTTCAGGCGGTGCGGCAAAACCGCCGGCAAAATGCCGCCACTTCG
CAGGCGGGGGCGCAGGTTGCCTTGCGCCGGGCGGATTTGGCACGCGCACAGGATGATTTGCGCCGCCGGTCTGCTTTGGCGGAATCGGGC
GCGGTGTCCGCCGAAGAGCTGGCACACGCCCGTGCGGCAGTGTCTCAGGCGCAGGCGGCGGTCAAAGCGGCTTTGGCGGAAGAATCTTCG
GCACGTGCGGCTTTGGGCGGTCAGGTTTCTTTGCGCGAACAGCCGGCGGTTCAGACGGCAATCGGCAGGTTGAAAGATGCGTGGTTGAAC
CTTCAGCGGACGCAAATCCGCGCGCCGGCGGACGGTCAGGTGGCGAAGCGTTCGGTGCAGGTCGGGCAGCAGGTGGCGGCAGGCGCGCCG
CTGATGGCGGTGGTGCCGCTGTCGGATGTGTGGGTGGATGCTAATTTTAAAGAGACGCAGTTGCGGCATATGAAAATCGGACAGCCTGCC
GAGCTGGTGTCCGATTTGTACGGCAAACAAATTGTTTATCGCGGCAGGGTGGCAGGTTTTTCGGCAGGTACGGGCAGCGCGTTTTCGCTG
ATTCCGGCGCAAAACGCAACGGGCAACTGGATTAAAGTGGTGCAGCGCGTCCCCGTCCGTATCGTGCTGAACCGCGAAGATGTGGACAGG
CATCCGTTGCGTATCGGTTTGTCGATGACGGTTAAAGTGGATACTTCCGCCGCAGGCGCGCCTGTTTCAAAAACGCCGGGTGCGGCATTG
CCGGAAATGGAAAGTACCGACTGGTCGGAAGTCGATCGGACGGTCGATGAAATCCTCGGGCAATCCGCGCCCTGA