linoleic acid [Antibiotic]

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Accession ARO:3003959
Synonym(s)Linolic acid Telfairic acid Linoleate
DefinitionLinoleic acid is a polyunsaturated omega-6 fatty acid. Linoleic acid has been found to have antibacterial activity, particularly in inhibiting the growth of Gram-positive bacterial species.
Drug Classantibacterial free fatty acids
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
1 ontology terms | Show
+ farAB confers_resistance_to_antibiotic
Publications

Dilika F, et al. 2000. Fitoterapia 71(4):450-2 Antibacterial activity of linoleic and oleic acids isolated from Helichrysum pedunculatum: a plant used during circumcision rites. (PMID 10925024)

Desbois AP, et al. 2010. Appl. Microbiol. Biotechnol. 85(6):1629-42 Antibacterial free fatty acids: activities, mechanisms of action and biotechnological potential. (PMID 19956944)

Lee EH, et al. 1999. Mol. Microbiol. 33(4):839-45 The farAB-encoded efflux pump mediates resistance of gonococci to long-chained antibacterial fatty acids. (PMID 10447892)

Greenway DL, et al. 1979. J. Gen. Microbiol. 115(1):233-45 Mechanism of the inhibitory action of linoleic acid on the growth of Staphylococcus aureus. (PMID 93615)