| Accession | ARO:3003955 |
| CARD Short Name | efpA |
| Definition | efpA is an MFS transporter found in Mycobacterium tuberculosis. |
| AMR Gene Family | major facilitator superfamily (MFS) antibiotic efflux pump |
| Drug Class | isoniazid-like antibiotic, rifamycin antibiotic |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Resistomes with Perfect Matches | Mycobacterium tuberculosisg+wgs |
| Resistomes with Sequence Variants | Mycobacterium tuberculosisg+wgs |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic efflux [Resistance Mechanism] + isoniazid-like antibiotic [Drug Class] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + rifamycin antibiotic [Drug Class] |
| Parent Term(s) | 3 ontology terms | Show + major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family] + confers_resistance_to_antibiotic rifampin [Antibiotic] + confers_resistance_to_antibiotic isoniazid [Antibiotic] |
| Publications | Rodrigues L, et al. 2012. Infect. Genet. Evol. 12(4):695-700 Contribution of efflux activity to isoniazid resistance in the Mycobacterium tuberculosis complex. (PMID 21871582) Doran JL, et al. 1997. Clin. Diagn. Lab. Immunol. 4(1):23-32 Mycobacterium tuberculosis efpA encodes an efflux protein of the QacA transporter family. (PMID 9008277) Li XZ, et al. 2004. Antimicrob Agents Chemother 48(7): 2415-2423. Efflux pump-mediated intrinsic drug resistance in Mycobacterium smegmatis. (PMID 15215089) |
Prevalence of efpA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Mycobacterium tuberculosis | 89.14% | 0% | 69.68% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 1000