isoniazid [Drug Class]

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Accession ARO:3000520
DefinitionIsoniazid is an organic compound that is the first-line anti tuberculosis medication in prevention and treatment. As a prodrug, it is activated by mycobacterial catalase-peroxidases such as M. tuberculosis KatG. Isoniazid inhibits mycolic acid synthesis, which prevents cell wall synthesis in mycobacteria.
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
14 ontology terms | Show
+ mycolic acid synthesis enzyme targeted by antibiotic targeted_by_antibiotic
+ antibiotic sensitive inhA targeted_by_antibiotic
+ antibiotic sensitive kasA targeted_by_antibiotic
+ Mycobacterium tuberculosis ndh with mutation conferring resistance to isoniazid confers_resistance_to_antibiotic
+ Mycobacterium tuberculosis kasA mutant conferring resistance to isoniazid confers_resistance_to_antibiotic
+ Mycolicibacterium smegmatis ndh with mutation conferring resistance to isoniazid confers_resistance_to_antibiotic
+ Mycobacterium tuberculosis variant bovis ndh with mutation conferring resistance to isoniazid confers_resistance_to_antibiotic
+ efpA confers_resistance_to_antibiotic
+ antibiotic resistant ndh [AMR Gene Family] confers_resistance_to_drug_class
+ determinant of isoniazid resistance confers_resistance_to_drug_class
+ isoniazid resistant katG [AMR Gene Family] confers_resistance_to_drug_class
+ antibiotic resistant fabI [AMR Gene Family] confers_resistance_to_drug_class
+ antibiotic resistant kasA [AMR Gene Family] confers_resistance_to_drug_class
+ antibiotic resistant inhA [AMR Gene Family] confers_resistance_to_drug_class
Publications

Suarez J, et al. 2009. J Biol Chem 284(11): 7017-7029. An oxyferrous heme/protein-based radical intermediate is catalytically competent in the catalase reaction of Mycobacterium tuberculosis catalase-peroxidase (KatG). (PMID 19139099)

Zhang Y and Young DB. 1993. Trends Microbiol 1(3): 109-113. Molecular mechanisms of isoniazid: a drug at the front line of tuberculosis control. (PMID 8143118)