| Ontology | CARD's Antibiotic Resistance Ontology |
| Accession | ARO:3000520 |
| Definition | Isoniazid is an organic compound that is the first-line anti tuberculosis medication in prevention and treatment. As a prodrug, it is activated by mycobacterial catalase-peroxidases such as M. tuberculosis KatG. Isoniazid inhibits mycolic acid synthesis, which prevents cell wall synthesis in mycobacteria. |
| SMILES | NNC(=O)c1ccncc1 |
| PubChem | 3767 |
| ChEMBL | CHEMBL64 |
| ChEBI | 6030 |
| CAS | 54-85-3 |
| Drug Class | isoniazid-like antibiotic |
| Classification | 2 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show + isoniazid-like antibiotic [Drug Class] |
| Sub-Term(s) | 25 ontology terms | Show + mycolic acid synthesis enzyme targeted by antibiotic targeted_by_antibiotic + antibiotic sensitive inhA targeted_by_antibiotic + antibiotic sensitive kasA targeted_by_antibiotic + Mycobacterium tuberculosis ndh with mutation conferring resistance to isoniazid confers_resistance_to_antibiotic + Mycobacterium tuberculosis kasA mutant conferring resistance to isoniazid confers_resistance_to_antibiotic + Mycolicibacterium smegmatis ndh with mutation conferring resistance to isoniazid confers_resistance_to_antibiotic + Mycobacterium tuberculosis variant bovis ndh with mutation conferring resistance to isoniazid confers_resistance_to_antibiotic + efpA confers_resistance_to_antibiotic + Mycobacterium tuberculosis Rv1258c mutations confer resistance to pyrazinamide, isoniazid, and streptomycin confers_resistance_to_antibiotic + Mycobacterium tuberculosis ahpC mutations confer resistance to isoniazid confers_resistance_to_antibiotic + Mycobacterium tuberculosis ethA mutations conferring resistance to isoniazid confers_resistance_to_antibiotic + Mycobacterium tuberculosis fabG1 mutations confer resistance to isoniazid confers_resistance_to_antibiotic + Mycobacterium tuberculosis furA mutations confer resistance to isoniazid confers_resistance_to_antibiotic + Mycobacterium tuberculosis inbR mutations conferring resistance to isoniazid confers_resistance_to_antibiotic + Mycobacterium tuberculosis inhA mutations conferring resistance to isoniazid confers_resistance_to_antibiotic + Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid confers_resistance_to_antibiotic + Mycobacterium tuberculosis mmaA3 mutations conferring resistance to isoniazid confers_resistance_to_antibiotic + Mycobacterium tuberculosis mshA mutations conferring resistance to isoniazid confers_resistance_to_antibiotic + Mycobacterium tuberculosis mshC mutations conferring resistance to isoniazid confers_resistance_to_antibiotic + Mycobacterium tuberculosis mymA mutations conferring resistance to isoniazid confers_resistance_to_antibiotic + Mycobacterium tuberculosis nat mutations conferring resistance to isoniazid confers_resistance_to_antibiotic + Mycobacterium tuberculosis nudC mutations conferring resistance to isoniazid confers_resistance_to_antibiotic + Mycobacterium tuberculosis sigI mutations conferring resistance to isoniazid confers_resistance_to_antibiotic + putative nickel/cobalt transporter confers_resistance_to_antibiotic + Mycobacterium tuberculosis iniA mutations conferring resistance to isoniazid confers_resistance_to_antibiotic |
| Publications | Suarez J, et al. 2009. J Biol Chem 284(11): 7017-7029. An oxyferrous heme/protein-based radical intermediate is catalytically competent in the catalase reaction of Mycobacterium tuberculosis catalase-peroxidase (KatG). (PMID 19139099) Zhang Y and Young DB. 1993. Trends Microbiol 1(3): 109-113. Molecular mechanisms of isoniazid: a drug at the front line of tuberculosis control. (PMID 8143118) |
| Curator | Description | Most Recent Edit |
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