isoniazid [Antibiotic]

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Accession ARO:3000520
DefinitionIsoniazid is an organic compound that is the first-line anti tuberculosis medication in prevention and treatment. As a prodrug, it is activated by mycobacterial catalase-peroxidases such as M. tuberculosis KatG. Isoniazid inhibits mycolic acid synthesis, which prevents cell wall synthesis in mycobacteria.
Drug Classisoniazid-like antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
25 ontology terms | Show
+ mycolic acid synthesis enzyme targeted by antibiotic targeted_by_antibiotic
+ antibiotic sensitive inhA targeted_by_antibiotic
+ antibiotic sensitive kasA targeted_by_antibiotic
+ Mycobacterium tuberculosis ndh with mutation conferring resistance to isoniazid confers_resistance_to_antibiotic
+ Mycobacterium tuberculosis kasA mutant conferring resistance to isoniazid confers_resistance_to_antibiotic
+ Mycolicibacterium smegmatis ndh with mutation conferring resistance to isoniazid confers_resistance_to_antibiotic
+ Mycobacterium tuberculosis variant bovis ndh with mutation conferring resistance to isoniazid confers_resistance_to_antibiotic
+ efpA confers_resistance_to_antibiotic
+ Mycobacterium tuberculosis Rv1258c mutations confer resistance to pyrazinamide, isoniazid, and streptomycin confers_resistance_to_antibiotic
+ Mycobacterium tuberculosis ahpC mutations confer resistance to isoniazid confers_resistance_to_antibiotic
+ Mycobacterium tuberculosis ethA mutations conferring resistance to isoniazid confers_resistance_to_antibiotic
+ Mycobacterium tuberculosis fabG1 mutations confer resistance to isoniazid confers_resistance_to_antibiotic
+ Mycobacterium tuberculosis furA mutations confer resistance to isoniazid confers_resistance_to_antibiotic
+ Mycobacterium tuberculosis inbR mutations conferring resistance to isoniazid confers_resistance_to_antibiotic
+ Mycobacterium tuberculosis inhA mutations conferring resistance to isoniazid confers_resistance_to_antibiotic
+ Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid confers_resistance_to_antibiotic
+ Mycobacterium tuberculosis mmaA3 mutations conferring resistance to isoniazid confers_resistance_to_antibiotic
+ Mycobacterium tuberculosis mshA mutations conferring resistance to isoniazid confers_resistance_to_antibiotic
+ Mycobacterium tuberculosis mshC mutations conferring resistance to isoniazid confers_resistance_to_antibiotic
+ Mycobacterium tuberculosis mymA mutations conferring resistance to isoniazid confers_resistance_to_antibiotic
+ Mycobacterium tuberculosis nat mutations conferring resistance to isoniazid confers_resistance_to_antibiotic
+ Mycobacterium tuberculosis nudC mutations conferring resistance to isoniazid confers_resistance_to_antibiotic
+ Mycobacterium tuberculosis sigI mutations conferring resistance to isoniazid confers_resistance_to_antibiotic
+ putative nickel/cobalt transporter confers_resistance_to_antibiotic
+ Mycobacterium tuberculosis iniA mutations conferring resistance to isoniazid confers_resistance_to_antibiotic
Publications

Suarez J, et al. 2009. J Biol Chem 284(11): 7017-7029. An oxyferrous heme/protein-based radical intermediate is catalytically competent in the catalase reaction of Mycobacterium tuberculosis catalase-peroxidase (KatG). (PMID 19139099)

Zhang Y and Young DB. 1993. Trends Microbiol 1(3): 109-113. Molecular mechanisms of isoniazid: a drug at the front line of tuberculosis control. (PMID 8143118)