mycolic acid synthesis enzyme targeted by antibiotic

Accession ARO:3000716
DefinitionMycolic acids are produced by mycobacteria. These fatty acids are required for the construction of cell walls. Enzymes that are targeted by antibiotics include synthases, elongases, and dehydrogenases.
Classification1 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ antibiotic target
+ targeted_by_antibiotic isoniazid [Antibiotic]
2 ontology terms | Show

Quemard A, et al. 1991. Antimicrob Agents Chemother 35(6): 1035-1039. Isoniazid inhibition of mycolic acid synthesis by cell extracts of sensitive and resistant strains of Mycobacterium aurum. (PMID 1656850)

Zhang Y and Young DB. 1993. Trends Microbiol 1(3): 109-113. Molecular mechanisms of isoniazid: a drug at the front line of tuberculosis control. (PMID 8143118)