mycolic acid synthesis enzyme targeted by antibiotic

Accession ARO:3000716
DefinitionMycolic acids are produced by mycobacteria. These fatty acids are required for the construction of cell walls. Enzymes that are targeted by antibiotics include synthases, elongases, and dehydrogenases.
Drug Classisoniazid
Classification1 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ targeted_by_antibiotic isoniazid [Drug Class]
+ antibiotic target
Sub-Term(s)
2 ontology terms | Show
Publications

Quemard A, et al. 1991. Antimicrob Agents Chemother 35(6): 1035-1039. Isoniazid inhibition of mycolic acid synthesis by cell extracts of sensitive and resistant strains of Mycobacterium aurum. (PMID 1656850)

Zhang Y and Young DB. 1993. Trends Microbiol 1(3): 109-113. Molecular mechanisms of isoniazid: a drug at the front line of tuberculosis control. (PMID 8143118)