| Accession | ARO:3005105 |
| Synonym(s) | Rv3854c |
| CARD Short Name | Mtub_ethA_INH |
| Definition | Mutations in Mycobacterium tuberculosis ethA conferring resistance to isoniazid. |
| AMR Gene Family | isoniazid resistant ethA |
| Drug Class | isoniazid-like antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Resistomes with Sequence Variants | Mycobacterium tuberculosisg+wgs |
| Classification | 9 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + mutation conferring antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic resistant gene variant or mutant + isoniazid-like antibiotic [Drug Class] + antibiotic resistant ethA |
| Parent Term(s) | 2 ontology terms | Show + confers_resistance_to_antibiotic isoniazid [Antibiotic] + isoniazid resistant ethA [AMR Gene Family] |
| Publications | Boonaiam S, et al. 2010. Clin Microbiol Infect 16(4):396-9 Genotypic analysis of genes associated with isoniazid and ethionamide resistance in MDR-TB isolates from Thailand. (PMID 19486070) Islam MM, et al. 2019. Clin. Microbiol. Infect. 25(8):1041.e1-1041.e7 Detection of novel mutations associated with independent resistance and cross-resistance to isoniazid and prothionamide in Mycobacterium tuberculosis clinical isolates. (PMID 30583053) |
Prevalence of Mycobacterium tuberculosis ethA mutations conferring resistance to isoniazid among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Mycobacterium tuberculosis | 1.23% | 0% | 0.74% | 0% |
Model Type: protein variant model
Model Definition: Protein Variant Models (PVM) perform a similar search as Protein Homolog Models (PHM), i.e. detect protein sequences based on their similarity to a curated reference sequence, but secondarily screen query sequences for curated sets of mutations to differentiate them from antibiotic susceptible wild-type alleles. PVMs are designed to detect AMR acquired via mutation of house-keeping genes or antibiotic targets, e.g. a mutated gyrase resistant to aminocoumarin antibiotics. PVMs include a protein reference sequence (often from antibiotic susceptible wild-type alleles), a curated bit-score cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of single point mutations, insertions, or deletions curated from the scientific literature. A Strict RGI match has a BLASTP bit-score above the curated BLASTP cutoff value and contains at least one curated mutation from amongst the mapped resistance variants, while a Loose RGI match has a bit-score less than the curated BLASTP bit-score cut-off but still contains at least one curated mutation from amongst the mapped resistance variants.
Bit-score Cut-off (blastP): 1000
Legend:
Published Variants:
| PMID: 19486070 | -nt43:G |
| PMID: 30583053 | P28S L35R G42D D56Y D58G W69C H102P Y141N I161V,G324R V179F T186P T189R R239Q,S266R Q246P Q246R,L446P Q254P Q254P,S266R R258R S266R,M373T S266R,P454L L267V R279STOP W289STOP S329P R331R A341V N345K A352E M372R A395D C403Y E420STOP F480S -nt1043:T -nt1133:C +nt11:A +nt1219:A +nt1247:A -nt1339:C +nt213:A +nt342:A -nt34:G -nt385:A -nt455:C +nt672:G +nt673:G -nt697:T -nt751:A +nt755:G +nt756:G +nt757:C +nt797:G -nt822:G -nt884:T |