Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid

Accession ARO:3003392
Synonym(s)Rv1908c
CARD Short NameMtub_katG_INH
DefinitionkatG is a catalase-peroxidase that catalyzes the activation of isoniazid. Isoniazid inhibits mycolic acid synthesis, which prevents cell wall synthesis in mycobacteria. Mutations in katG results in inability to activate isoniazid. Over 280 different mutations have been documented in PubMed for katG, with mutations to Ser315 being the most prevalent.
AMR Gene Familyisoniazid resistant katG
Drug Classisoniazid-like antibiotic
Resistance Mechanismantibiotic target alteration
Resistomes with Sequence VariantsMycobacterium tuberculosisg+wgs
Classification9 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_antibiotic isoniazid [Antibiotic]
+ isoniazid resistant katG [AMR Gene Family]
Publications

Jagielski T, et al. 2013. Pneumonol Alergol Pol 81(4): 298-307. Identification and analysis of mutations in the katG gene in multidrug-resistant Mycobacterium tuberculosis clinical isolates. (PMID 23744165)

Khadka JB, et al. 2011. Nepal Med Coll J 13(3): 147-151. Study of rifampicin and isoniazid resistance mutation genes of M. tuberculosis isolates in Nepal. (PMID 22808802)

Cade CE, et al. 2010. Protein Sci. 19(3):458-74 Isoniazid-resistance conferring mutations in Mycobacterium tuberculosis KatG: catalase, peroxidase, and INH-NADH adduct formation activities. (PMID 20054829)

Ando H, et al. 2010. Antimicrob. Agents Chemother. 54(5):1793-9 Identification of katG mutations associated with high-level isoniazid resistance in Mycobacterium tuberculosis. (PMID 20211896)

Torres JN, et al. 2015. Emerg Microbes Infect 4(7):e42 Novel katG mutations causing isoniazid resistance in clinical M. tuberculosis isolates. (PMID 26251830)

Rouse DA, et al. 1995. Antimicrob. Agents Chemother. 39(11):2472-7 Characterization of the katG and inhA genes of isoniazid-resistant clinical isolates of Mycobacterium tuberculosis. (PMID 8585728)

Tseng ST, et al. 2015. J Microbiol Immunol Infect 48(3):249-55 The mutations of katG and inhA genes of isoniazid-resistant Mycobacterium tuberculosis isolates in Taiwan. (PMID 24184004)

Lu J, et al. 2014. Mol Med Rep 9(5):2031-5 Analysis of mutational characteristics of the drug-resistant gene katG in multi-drug resistant Mycobacterium tuberculosis L-form among patients with pneumoconiosis complicated with tuberculosis. (PMID 24626681)

de Freitas FA, et al. 2014. PLoS ONE 9(8):e104100 Multidrug resistant Mycobacterium tuberculosis: a retrospective katG and rpoB mutation profile analysis in isolates from a reference center in Brazil. (PMID 25093512)

Loots du T, et al. 2014. Antimicrob. Agents Chemother. 58(4):2144-9 An altered Mycobacterium tuberculosis metabolome induced by katG mutations resulting in isoniazid resistance. (PMID 24468786)

Brossier F, et al. 2015. J. Clin. Microbiol. 53(9):3104 Characterization of a Clone of Mycobacterium tuberculosis Clinical Isolates with Mutations in KatG (A110V), EthA (Q269STOP), and the inhA Promoter (-15C→T). (PMID 26157154)

Salvatore PP, et al. 2016. J. Infect. Dis. 213(1):149-55 Fitness Costs of Drug Resistance Mutations in Multidrug-Resistant Mycobacterium tuberculosis: A Household-Based Case-Control Study. (PMID 26092854)

Ramasubban G, et al. 2011. Int. J. Antimicrob. Agents 37(4):368-72 Detection of novel coupled mutations in the katG gene (His276Met, Gln295His and Ser315Thr) in a multidrug-resistant Mycobacterium tuberculosis strain from Chennai, India, and insight into the molecular mechanism of isoniazid resistance using structural bioinformatics approaches. (PMID 21330112)

Cockerill FR, et al. 1995. J. Infect. Dis. 171(1):240-5 Rapid identification of a point mutation of the Mycobacterium tuberculosis catalase-peroxidase (katG) gene associated with isoniazid resistance. (PMID 7798673)

Morlock GP, et al. 2003. Antimicrob Agents Chemother 47(12): 3799-3805. ethA, inhA, and katG loci of ethionamide-resistant clinical Mycobacterium tuberculosis isolates. (PMID 14638486)

Abe C, et al. 2008. J. Clin. Microbiol. 46(7):2263-8 Biological and molecular characteristics of Mycobacterium tuberculosis clinical isolates with low-level resistance to isoniazid in Japan. (PMID 18508939)

Hazbón MH, et al. 2006. Antimicrob. Agents Chemother. 50(8):2640-9 Population genetics study of isoniazid resistance mutations and evolution of multidrug-resistant Mycobacterium tuberculosis. (PMID 16870753)

Bolotin S, et al. 2009. J. Antimicrob. Chemother. 64(2):263-6 Molecular characterization of drug-resistant Mycobacterium tuberculosis isolates from Ontario, Canada. (PMID 19520719)

Ramaswamy S, et al. 1998. Tuber. Lung Dis. 79(1):3-29 Molecular genetic basis of antimicrobial agent resistance in Mycobacterium tuberculosis: 1998 update. (PMID 10645439)

Takawira FT, et al. 2017. Pan Afr Med J 27:145 Mutations in rpoB and katG genes of multidrug resistant mycobacterium tuberculosis undetectable using genotyping diagnostic methods. (PMID 28904673)

Bouziane F, et al. 2019. J Glob Antimicrob Resist : First genetic characterization of multi-drug resistant Mycobacterium tuberculosis isolates from Algeria. (PMID 31100498)

Islam MM, et al. 2019. Clin. Microbiol. Infect. 25(8):1041.e1-1041.e7 Detection of novel mutations associated with independent resistance and cross-resistance to isoniazid and prothionamide in Mycobacterium tuberculosis clinical isolates. (PMID 30583053)

Thwe EP, et al. 2021. World J Microbiol Biotechnol 37(11):194 Novel mutations detected from drug resistant Mycobacterium tuberculosis isolated from North East of Thailand. (PMID 34642828)

Napier G, et al. 2023. Sci Rep 13(1):623 Large-scale genomic analysis of Mycobacterium tuberculosis reveals extent of target and compensatory mutations linked to multi-drug resistant tuberculosis. (PMID 36635309)

Ezewudo M, et al. 2018. Sci Rep 8(1):15382 Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase. (PMID 30337678)

The CRyPTIC Consortium 2022. PLoS Biol 20(8):e3001721 A data compendium associating the genomes of 12,289 Mycobacterium tuberculosis isolates with quantitative resistance phenotypes to 13 antibiotics. (PMID 35944069)

World Health Organization. 2023. ISBN 978-92-4-008241-0. Catalogue of mutations in Mycobacterium tuberculosis complex and their association with drug resistance. Second Edition. (ISBN 978-92-4-008241-0)

Resistomes

Prevalence of Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein variant model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GIGRDI-AMR2
Mycobacterium tuberculosis99.8%0%93.47%0%0%
Show Perfect Only


Detection Models

Model Type: protein variant model

Model Definition: Protein Variant Models (PVM) perform a similar search as Protein Homolog Models (PHM), i.e. detect protein sequences based on their similarity to a curated reference sequence, but secondarily screen query sequences for curated sets of mutations to differentiate them from antibiotic susceptible wild-type alleles. PVMs are designed to detect AMR acquired via mutation of house-keeping genes or antibiotic targets, e.g. a mutated gyrase resistant to aminocoumarin antibiotics. PVMs include a protein reference sequence (often from antibiotic susceptible wild-type alleles), a curated bit-score cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of single point mutations, insertions, or deletions curated from the scientific literature. A Strict RGI match has a BLASTP bit-score above the curated BLASTP cutoff value and contains at least one curated mutation from amongst the mapped resistance variants, while a Loose RGI match has a bit-score less than the curated BLASTP bit-score cut-off but still contains at least one curated mutation from amongst the mapped resistance variants.

Bit-score Cut-off (blastP): 1400

PubMed: mutation data hand curated from the scientific literature, evaluated as conferring resistance (R). CRyPTIC: mutation data acquired from the CRyPTIC catalog, evaluated as resistant (R), susceptible (S), or undetermined (U). ReSeqTB: mutation data acquired from the ReSeqTB catalog, evaluated as conferring resistance (Minimal, Moderate, High), not conferring resistance (None), or Indeterminate. WHO: mutation data acquired from the WHO 2023 catalog, evaluated as resistant (R), susceptible (S), or undetermined (U).

MutationMutation typePubMedReSeqTBCRyPTICWHO
V1Varsingle resistance variantno datano datano dataWHO-R
P2Ssingle resistance variantPMID:7798673no datano datano data
S17Tsingle resistance variantPMID:25093512no datano datano data
S17Nsingle resistance variantPMID:7798673no datano datano data
G19Dsingle resistance variantPMID:7798673no datano datano data
C20R,S315Tmultiple resistance variantsPMID:30583053no datano datano data
Y28Ternonsense mutationno datano datano dataWHO-R
G32Dsingle resistance variantPMID:26251830no datano datano data
G33Vsingle resistance variantPMID:30583053no datano datano data
W39Ternonsense mutationno datano datano dataWHO-R
V47Esingle resistance variantPMID:26251830no datano datano data
-nt54:cdeletion mutation from nucleotide sequencePMID:25093512no datano datano data
-nt60:adeletion mutation from nucleotide sequencePMID:25093512no datano datano data
D63Esingle resistance variantPMID:8585728no datano datano data
Y64Ssingle resistance variantPMID:26251830no datano datano data
V68Gsingle resistance variantPMID:23744165no dataCRyPTIC-Sno data
R78Psingle resistance variantPMID:36635309no datano datano data
-nt81:cdeletion mutation from nucleotide sequencePMID:25093512no datano datano data
Q88Psingle resistance variantPMID:36635309no datano datano data
Q88Ternonsense mutationno datano datano dataWHO-R
W90Ternonsense mutationno datano datano dataWHO-R
W90Rsingle resistance variantPMID:36635309no dataCRyPTIC-Rno data
W91Rsingle resistance variantPMID:23744165no datano dataWHO-U
W91Ternonsense mutationPMID:30583053no datano datano data
P92S,S315Tmultiple resistance variantsPMID:30583053no datano datano data
A93Tsingle resistance variantPMID:25093512no datano datano data
Y95Csingle resistance variantPMID:26251830no datano datano data
H97Rsingle resistance variantPMID:20211896no datano datano data
Y98Csingle resistance variantPMID:24184004no datano dataWHO-U
L101Psingle resistance variantPMID:23744165no datano datano data
R104Qsingle resistance variantno datano dataCRyPTIC-RWHO-U
R104Lsingle resistance variantPMID:20054829no datano dataWHO-U
W107Fsingle resistance variantPMID:20054829no datano datano data
W107Ternonsense mutationno datano datano dataWHO-R
W107Rsingle resistance variantPMID:20054829no datano datano data
H108Esingle resistance variantPMID:20054829no datano datano data
H108Qsingle resistance variantPMID:8585728no datano datano data
A109Tsingle resistance variantPMID:36635309no datano datano data
A109Vsingle resistance variantno datano dataCRyPTIC-RWHO-U
A110Vsingle resistance variantPMID:26157154no datano dataWHO-U
G111Ssingle resistance variantPMID:30583053no datano datano data
Y113Ternonsense mutationno datano datano dataWHO-R
A122Dsingle resistance variantPMID:36635309no datano dataWHO-U
G123Esingle resistance variantPMID:20211896no datano datano data
G124Ssingle resistance variantPMID:36635309no datano datano data
G125Dsingle resistance variantno datano dataCRyPTIC-RWHO-U
G125Ssingle resistance variantPMID:30583053no datano datano data
M126I,R496Lmultiple resistance variantsPMID:31100498no datano datano data
-nt126:gdeletion mutation from nucleotide sequencePMID:25093512no datano datano data
M126Isingle resistance variantPMID:23744165no datano datano data
Q127Psingle resistance variantPMID:24184004no datano dataWHO-U
Q127Esingle resistance variantPMID:20211896no datano datano data
R128Qsingle resistance variantPMID:23744165no datano datano data
P131Rsingle resistance variantPMID:23744165no datano datano data
P131Qsingle resistance variantPMID:23744165no datano datano data
P131Tsingle resistance variantPMID:26251830no datano datano data
L132Rsingle resistance variantPMID:36635309no datano datano data
N133Tsingle resistance variantPMID:20211896no datano datano data
+nt135:tinsertion mutation from nucleotide sequencePMID:23744165no datano datano data
N138Ssingle resistance variantPMID:20054829no datano dataWHO-U
N138Dsingle resistance variantPMID:20054829no datano dataWHO-U
A139Psingle resistance variantPMID:26251830no datano datano data
A139Vsingle resistance variantPMID:26092854no datano datano data
S140Nsingle resistance variantPMID:7798673no datano datano data
L141Fsingle resistance variantno datano dataCRyPTIC-RWHO-U
D142Gsingle resistance variantPMID:26251830no dataCRyPTIC-RWHO-U
L147Psingle resistance variantPMID:30583053no datano datano data
W149Ternonsense mutationno datano datano dataWHO-R
Y155Ternonsense mutationno datano datano dataWHO-R
L159Psingle resistance variantno datano dataCRyPTIC-RWHO-U
W161Csingle resistance variantPMID:36635309no datano datano data
W161Ternonsense mutationno datano datano dataWHO-R
A162Vsingle resistance variantPMID:26251830no dataCRyPTIC-Sno data
G169Ssingle resistance variantPMID:36635309no datano datano data
C171Ternonsense mutationno datano datano dataWHO-R
S175Ternonsense mutationno datano datano dataWHO-R
M176Tsingle resistance variantPMID:20211896no datano datano data
T180Ksingle resistance variantno datano dataCRyPTIC-Rno data
G182Rsingle resistance variantPMID:36635309no dataCRyPTIC-RWHO-U
F183Lsingle resistance variantPMID:36635309no datano dataWHO-U
D189Gsingle resistance variantPMID:36635309no datano dataWHO-U
D189Nsingle resistance variantPMID:36635309no datano dataWHO-U
W191Rsingle resistance variantno dataReSeqTB-HighCRyPTIC-Rno data
W191Gsingle resistance variantno datano dataCRyPTIC-Rno data
D194Gsingle resistance variantPMID:26251830no datano datano data
D194Ysingle resistance variantPMID:23744165no datano datano data
W198Ternonsense mutationno datano datano dataWHO-R
W204Ternonsense mutationno datano datano dataWHO-R
S211G,S315Tmultiple resistance variantsPMID:30583053no datano datano data
Q224Esingle resistance variantPMID:7798673no datano datano data
Y229Fsingle resistance variantPMID:20054829no datano datano data
P232Ssingle resistance variantPMID:20211896no datano dataWHO-U
P232Rsingle resistance variantno datano dataCRyPTIC-RWHO-U
E233Gsingle resistance variantPMID:36635309no datano datano data
-nt241:gdeletion mutation from nucleotide sequencePMID:25093512no datano datano data
A243Ssingle resistance variantPMID:7798673no datano datano data
-nt249:gdeletion mutation from nucleotide sequencePMID:25093512no datano datano data
M255Ysingle resistance variantPMID:20054829no datano datano data
M255Csingle resistance variantPMID:20054829no datano datano data
M255Isingle resistance variantPMID:20054829no datano datano data
A256Tsingle resistance variantPMID:26251830no datano datano data
M257Vsingle resistance variantPMID:36635309no datano datano data
T262Rsingle resistance variantPMID:8585728no datano datano data
G269Dsingle resistance variantPMID:26251830no datano dataWHO-U
G269Rsingle resistance variantPMID:24184004no datano datano data
T271Isingle resistance variantPMID:36635309no datano dataWHO-U
T275Psingle resistance variantPMID:20054829no datano dataWHO-U
T275Vsingle resistance variantPMID:20054829no datano datano data
H276Msingle resistance variantPMID:21330112no datano datano data
G279V,L436Pmultiple resistance variantsPMID:30583053no datano datano data
G279Dsingle resistance variantPMID:14638486no datano dataWHO-U
G285Dsingle resistance variantPMID:18508939no datano datano data
Q295Hsingle resistance variantPMID:21330112no datano datano data
G297Vsingle resistance variantno datano dataCRyPTIC-RWHO-U
G299Ssingle resistance variantPMID:20211896no datano dataWHO-U
W300Gsingle resistance variantPMID:20054829no datano dataWHO-U
W300Ternonsense mutationno datano datano dataWHO-R
W300Csingle resistance variantno datano dataCRyPTIC-RWHO-U
S303Csingle resistance variantPMID:28904673no datano datano data
S303Lsingle resistance variantPMID:28904673no datano datano data
Y304Ternonsense mutationPMID:28904673no datano datano data
T306Psingle resistance variantPMID:26251830no datano datano data
D311Nsingle resistance variantPMID:28904673no datano datano data
D311Ssingle resistance variantPMID:28904673no datano datano data
A312Esingle resistance variantPMID:36635309no datano datano data
A312Psingle resistance variantPMID:30583053no datano dataWHO-U
S315Rsingle resistance variantPMID:20211896ReSeqTB-Highno dataWHO-R
S315T,V581Gmultiple resistance variantsPMID:30583053no datano datano data
S315Isingle resistance variantPMID:20054829no dataCRyPTIC-RWHO-R
S315Gsingle resistance variantPMID:20054829no datano dataWHO-U
S315Varsingle resistance variantno datano dataCRyPTIC-Rno data
S315Tsingle resistance variantPMID:8585728ReSeqTB-HighCRyPTIC-RWHO-R
S315Nsingle resistance variantPMID:20054829ReSeqTB-HighCRyPTIC-RWHO-R
S315T,G466Rmultiple resistance variantsPMID:30583053no datano datano data
G316Dsingle resistance variantPMID:16870753no datano datano data
I317Vsingle resistance variantno dataReSeqTB-Highno datano data
W321Ternonsense mutationno datano datano dataWHO-R
W321Fsingle resistance variantPMID:20054829no datano datano data
+nt325:tinsertion mutation from nucleotide sequencePMID:25093512no datano datano data
T326Psingle resistance variantPMID:36635309no datano dataWHO-U
W328Gsingle resistance variantPMID:20054829no datano datano data
W328Fsingle resistance variantPMID:20054829no datano datano data
W328Lsingle resistance variantno datano dataCRyPTIC-RWHO-R
I335Tsingle resistance variantPMID:8585728no datano datano data
Y337Csingle resistance variantPMID:20054829no datano dataWHO-U
A350Ssingle resistance variantPMID:8585728no datano datano data
W351Ternonsense mutationno datano datano dataWHO-R
Q352Esingle resistance variantPMID:24184004no datano datano data
Q352Ternonsense mutationno datano datano dataWHO-R
P365Rsingle resistance variantPMID:34642828no datano datano data
-nt368:gdeletion mutation from nucleotide sequencePMID:25093512no datano datano data
A379Tsingle resistance variantPMID:24184004no datano datano data
S383Psingle resistance variantPMID:20211896no datano datano data
R385Psingle resistance variantPMID:36635309no datano datano data
R385Wsingle resistance variantPMID:26251830no datano datano data
D387Hsingle resistance variantPMID:20211896no datano datano data
D387Gsingle resistance variantPMID:26251830no datano dataWHO-U
+nt392:tinsertion mutation from nucleotide sequencePMID:25093512no datano datano data
T394Msingle resistance variantPMID:26251830no datano datano data
W397Ternonsense mutationno datano datano dataWHO-R
W412Ternonsense mutationno datano datano dataWHO-R
Y413Csingle resistance variantPMID:36635309no datano datano data
Y413Ternonsense mutationno datano datano dataWHO-R
H417Qsingle resistance variantPMID:30583053no datano datano data
R418Lsingle resistance variantPMID:20054829no datano datano data
D419Hsingle resistance variantPMID:20211896no datano dataWHO-U
D419Ysingle resistance variantPMID:36635309no datano dataWHO-U
M420Tsingle resistance variantPMID:20211896no datano datano data
L427Isingle resistance variantPMID:28904673no datano datano data
L430Vsingle resistance variantPMID:28904673no datano datano data
V431A,G490Smultiple resistance variantsPMID:30583053no datano datano data
T435Rsingle resistance variantPMID:28904673no datano datano data
L436Gsingle resistance variantPMID:28904673no datano datano data
W438Ternonsense mutationno datano datano dataWHO-R
Q439Psingle resistance variantPMID:26251830no datano dataWHO-U
Q439Hsingle resistance variantPMID:36635309no datano datano data
E454Ternonsense mutationPMID:23744165no datano datano data
S457Isingle resistance variantPMID:19520719no datano datano data
Q461Psingle resistance variantPMID:30583053no datano dataWHO-U
R463Lsingle resistance variantPMID:8585728ReSeqTB-MinimalCRyPTIC-SWHO-S
Q471Ysingle resistance variantPMID:28904673no datano datano data
Q471Hsingle resistance variantPMID:28904673no datano datano data
L472Isingle resistance variantPMID:28904673no datano datano data
L472Ksingle resistance variantPMID:28904673no datano datano data
L472Qsingle resistance variantPMID:28904673no datano datano data
V473Wsingle resistance variantPMID:28904673no datano datano data
V473Gsingle resistance variantPMID:28904673no datano datano data
V473Nsingle resistance variantPMID:28904673no datano datano data
V473Dsingle resistance variantPMID:28904673no datano datano data
V473Rsingle resistance variantPMID:28904673no datano datano data
V473Msingle resistance variantPMID:28904673no datano datano data
V473Ysingle resistance variantPMID:28904673no datano datano data
V473Ssingle resistance variantPMID:28904673no datano datano data
V473Isingle resistance variantPMID:28904673no datano datano data
V473Ksingle resistance variantPMID:28904673no datano datano data
V473Fsingle resistance variantPMID:28904673no datano datano data
W477Ternonsense mutationno datano datano dataWHO-R
S481Lsingle resistance variantno datano dataCRyPTIC-RWHO-U
F483Lsingle resistance variantPMID:26251830no datano dataWHO-U
R484Hsingle resistance variantPMID:36635309no datano dataWHO-U
R489Ssingle resistance variantPMID:20211896no datano datano data
W505Ternonsense mutationno datano dataCRyPTIC-RWHO-R
E506Ternonsense mutationPMID:24184004no datano datano data
N508Dsingle resistance variantPMID:30583053no datano datano data
+nt518:ggtcinsertion mutation from nucleotide sequencePMID:24184004no datano datano data
A541Dsingle resistance variantPMID:26251830no datano datano data
D542Hsingle resistance variantPMID:20211896no datano datano data
A550Dsingle resistance variantPMID:7798673no datano datano data
-nt571:ggcggcdeletion mutation from nucleotide sequencePMID:20211896no datano datano data
L587Msingle resistance variantPMID:20054829no datano datano data
E588Ternonsense mutationno datano datano dataWHO-R
G593Dsingle resistance variantPMID:10645439no datano datano data
N596S,Y597Hmultiple resistance variantsPMID:26251830no datano datano data
E607Ternonsense mutationno datano datano dataWHO-R
E607Asingle resistance variantPMID:30583053no datano datano data
A614Esingle resistance variantno datano dataCRyPTIC-RWHO-U
M624Vsingle resistance variantPMID:26251830no datano datano data
G629Ssingle resistance variantPMID:8585728no datano datano data
R632Csingle resistance variantPMID:20211896no datano datano data
V633Asingle resistance variantno datano dataCRyPTIC-Rno data
N655Dsingle resistance variantPMID:36635309no datano datano data
N660Dsingle resistance variantPMID:30583053no datano datano data
T667Psingle resistance variantPMID:26251830ReSeqTB-Highno datano data
W668Ternonsense mutationno datano datano dataWHO-R
S671Ternonsense mutationno datano datano dataWHO-R
D675Ysingle resistance variantPMID:36635309no datano datano data
T677Psingle resistance variantPMID:36635309no datano datano data
W689Ternonsense mutationno datano datano dataWHO-R
S700Psingle resistance variantno datano dataCRyPTIC-RWHO-U
L704Ssingle resistance variantno datano dataCRyPTIC-Rno data
W728Ternonsense mutationno datano datano dataWHO-R
D735Nsingle resistance variantPMID:20054829no datano datano data
-nt1293:gdeletion mutation from nucleotide sequencePMID:25093512no datano datano data
-nt1384:adeletion mutation from nucleotide sequencePMID:30583053no datano datano data
-nt1501:gdeletion mutation from nucleotide sequencePMID:25093512no datano datano data
-nt1525:adeletion mutation from nucleotide sequencePMID:25093512no datano datano data

>gb|NP_216424.1|-|Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid [Mycobacterium tuberculosis H37Rv]
MPEQHPPITETTTGAASNGCPVVGHMKYPVEGGGNQDWWPNRLNLKVLHQNPAVADPMGA
AFDYAAEVATIDVDALTRDIEEVMTTSQPWWPADYGHYGPLFIRMAWHAAGTYRIHDGRG
GAGGGMQRFAPLNSWPDNASLDKARRLLWPVKKKYGKKLSWADLIVFAGNCALESMGFKT
FGFGFGRVDQWEPDEVYWGKEATWLGDERYSGKRDLENPLAAVQMGLIYVNPEGPNGNPD
PMAAAVDIRETFRRMAMNDVETAALIVGGHTFGKTHGAGPADLVGPEPEAAPLEQMGLGW
KSSYGTGTGKDAITSGIEVVWTNTPTKWDNSFLEILYGYEWELTKSPAGAWQYTAKDGAG
AGTIPDPFGGPGRSPTMLATDLSLRVDPIYERITRRWLEHPEELADEFAKAWYKLIHRDM
GPVARYLGPLVPKQTLLWQDPVPAVSHDLVGEAEIASLKSQIRASGLTVSQLVSTAWAAA
SSFRGSDKRGGANGGRIRLQPQVGWEVNDPDGDLRKVIRTLEEIQESFNSAAPGNIKVSF
ADLVVLGGCAAIEKAAKAAGHNITVPFTPGRTDASQEQTDVESFAVLEPKADGFRNYLGK
GNPLPAEYMLLDKANLLTLSAPEMTVLVGGLRVLGANYKRLPLGVFTEASESLTNDFFVN
LLDMGITWEPSPADDGTYQGKDGSGKVKWTGSRVDLVFGSNSELRALVEVYGADDAQPKF
VQDFVAAWDKVMNLDRFDVR



>gb|NC_000962.3|-|2153889-2156111|Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid [Mycobacterium tuberculosis H37Rv]
GTGCCCGAGCAACACCCACCCATTACAGAAACCACCACCGGAGCCGCTAGCAACGGCTGTCCCGTCGTGGGTCATATGAAATACCCCGTC
GAGGGCGGCGGAAACCAGGACTGGTGGCCCAACCGGCTCAATCTGAAGGTACTGCACCAAAACCCGGCCGTCGCTGACCCGATGGGTGCG
GCGTTCGACTATGCCGCGGAGGTCGCGACCATCGACGTTGACGCCCTGACGCGGGACATCGAGGAAGTGATGACCACCTCGCAGCCGTGG
TGGCCCGCCGACTACGGCCACTACGGGCCGCTGTTTATCCGGATGGCGTGGCACGCTGCCGGCACCTACCGCATCCACGACGGCCGCGGC
GGCGCCGGGGGCGGCATGCAGCGGTTCGCGCCGCTTAACAGCTGGCCCGACAACGCCAGCTTGGACAAGGCGCGCCGGCTGCTGTGGCCG
GTCAAGAAGAAGTACGGCAAGAAGCTCTCATGGGCGGACCTGATTGTTTTCGCCGGCAACTGCGCGCTGGAATCGATGGGCTTCAAGACG
TTCGGGTTCGGCTTCGGCCGGGTCGACCAGTGGGAGCCCGATGAGGTCTATTGGGGCAAGGAAGCCACCTGGCTCGGCGATGAGCGTTAC
AGCGGTAAGCGGGATCTGGAGAACCCGCTGGCCGCGGTGCAGATGGGGCTGATCTACGTGAACCCGGAGGGGCCGAACGGCAACCCGGAC
CCCATGGCCGCGGCGGTCGACATTCGCGAGACGTTTCGGCGCATGGCCATGAACGACGTCGAAACAGCGGCGCTGATCGTCGGCGGTCAC
ACTTTCGGTAAGACCCATGGCGCCGGCCCGGCCGATCTGGTCGGCCCCGAACCCGAGGCTGCTCCGCTGGAGCAGATGGGCTTGGGCTGG
AAGAGCTCGTATGGCACCGGAACCGGTAAGGACGCGATCACCAGCGGCATCGAGGTCGTATGGACGAACACCCCGACGAAATGGGACAAC
AGTTTCCTCGAGATCCTGTACGGCTACGAGTGGGAGCTGACGAAGAGCCCTGCTGGCGCTTGGCAATACACCGCCAAGGACGGCGCCGGT
GCCGGCACCATCCCGGACCCGTTCGGCGGGCCAGGGCGCTCCCCGACGATGCTGGCCACTGACCTCTCGCTGCGGGTGGATCCGATCTAT
GAGCGGATCACGCGTCGCTGGCTGGAACACCCCGAGGAATTGGCCGACGAGTTCGCCAAGGCCTGGTACAAGCTGATCCACCGAGACATG
GGTCCCGTTGCGAGATACCTTGGGCCGCTGGTCCCCAAGCAGACCCTGCTGTGGCAGGATCCGGTCCCTGCGGTCAGCCACGACCTCGTC
GGCGAAGCCGAGATTGCCAGCCTTAAGAGCCAGATCCGGGCATCGGGATTGACTGTCTCACAGCTAGTTTCGACCGCATGGGCGGCGGCG
TCGTCGTTCCGTGGTAGCGACAAGCGCGGCGGCGCCAACGGTGGTCGCATCCGCCTGCAGCCACAAGTCGGGTGGGAGGTCAACGACCCC
GACGGGGATCTGCGCAAGGTCATTCGCACCCTGGAAGAGATCCAGGAGTCATTCAACTCCGCGGCGCCGGGGAACATCAAAGTGTCCTTC
GCCGACCTCGTCGTGCTCGGTGGCTGTGCCGCCATAGAGAAAGCAGCAAAGGCGGCTGGCCACAACATCACGGTGCCCTTCACCCCGGGC
CGCACGGATGCGTCGCAGGAACAAACCGACGTGGAATCCTTTGCCGTGCTGGAGCCCAAGGCAGATGGCTTCCGAAACTACCTCGGAAAG
GGCAACCCGTTGCCGGCCGAGTACATGCTGCTCGACAAGGCGAACCTGCTTACGCTCAGTGCCCCTGAGATGACGGTGCTGGTAGGTGGC
CTGCGCGTCCTCGGCGCAAACTACAAGCGCTTACCGCTGGGCGTGTTCACCGAGGCCTCCGAGTCACTGACCAACGACTTCTTCGTGAAC
CTGCTCGACATGGGTATCACCTGGGAGCCCTCGCCAGCAGATGACGGGACCTACCAGGGCAAGGATGGCAGTGGCAAGGTGAAGTGGACC
GGCAGCCGCGTGGACCTGGTCTTCGGGTCCAACTCGGAGTTGCGGGCGCTTGTCGAGGTCTATGGCGCCGATGACGCGCAGCCGAAGTTC
GTGCAGGACTTCGTCGCTGCCTGGGACAAGGTGATGAACCTCGACAGGTTCGACGTGCGCTGA

Curator Acknowledgements
Curator Description Most Recent Edit