| Accession | ARO:3004928 |
| CARD Short Name | Mtub_mymA_INH |
| Definition | Mutations that occur in the mymA operon that result in or contribute to antibiotic resistance to isoniazid. |
| AMR Gene Family | isoniazid resistant mymA |
| Drug Class | isoniazid-like antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Classification | 9 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + determinant of antibiotic resistance + mutation conferring antibiotic resistance + antibiotic resistant gene variant or mutant + antibiotic molecule + antibiotic resistant mymA + isoniazid-like antibiotic [Drug Class] |
| Parent Term(s) | 2 ontology terms | Show + isoniazid resistant mymA [AMR Gene Family] + confers_resistance_to_antibiotic isoniazid [Antibiotic] |
| Publications | Kandler JL, et al. 2018. Antimicrob Agents Chemother 62(10): Validation of Novel Mycobacterium tuberculosis Isoniazid Resistance Mutations Not Detectable by Common Molecular Tests. (PMID 30082293) |
Prevalence of Mycobacterium tuberculosis mymA mutations conferring resistance to isoniazid among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| No prevalence data | ||||
Model Type: protein variant model
Model Definition: Protein Variant Models (PVM) perform a similar search as Protein Homolog Models (PHM), i.e. detect protein sequences based on their similarity to a curated reference sequence, but secondarily screen query sequences for curated sets of mutations to differentiate them from antibiotic susceptible wild-type alleles. PVMs are designed to detect AMR acquired via mutation of house-keeping genes or antibiotic targets, e.g. a mutated gyrase resistant to aminocoumarin antibiotics. PVMs include a protein reference sequence (often from antibiotic susceptible wild-type alleles), a curated bit-score cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of single point mutations, insertions, or deletions curated from the scientific literature. A Strict RGI match has a BLASTP bit-score above the curated BLASTP cutoff value and contains at least one curated mutation from amongst the mapped resistance variants, while a Loose RGI match has a bit-score less than the curated BLASTP bit-score cut-off but still contains at least one curated mutation from amongst the mapped resistance variants.
Bit-score Cut-off (blastP): 980
Legend:
Published Variants:
PMID in progress (TB): W271STOP I32T I81S V94I A205T M371I M451V
ReSeqTB:
| High Confidence | M371I A205T W271STOP |
| Indeterminate Confidence | M451V I81S V94I I32T |