| Accession | ARO:3000167 |
| Synonym(s) | tetC |
| CARD Short Name | tet(C) |
| Definition | Tet(C) is a tetracycline efflux pump found in many species of Gram-negative bacteria. It is typically found in plasmid DNA. |
| AMR Gene Family | major facilitator superfamily (MFS) antibiotic efflux pump |
| Drug Class | tetracycline antibiotic |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Resistomes with Perfect Matches | Achromobacter xylosoxidansg+wgs+gi, Acinetobacter baumanniig, Aeromonas caviaeg+wgs, Aeromonas veroniip, Bacillus subtilisg, Bifidobacterium bifidumwgs, Burkholderia cepaciag+wgs, Citrobacter freundiiwgs, Citrobacter werkmaniiwgs, Citrobacter youngaewgs, Deinococcus radioduransg, Enterobacter asburiaewgs, Enterobacter cancerogenuswgs, Enterobacter cloacaewgs, Enterobacter hormaecheip+wgs, Enterobacter kobeiwgs, Enterobacter roggenkampiiwgs, Escherichia coliwgs, Fusobacterium periodonticumwgs, Helicobacter cinaediwgs, Klebsiella oxytocawgs, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaewgs, Laribacter hongkongensiswgs, Leclercia adecarboxylatawgs, Micrococcus luteuswgs, Moraxella osloensiswgs, Phocaeicola doreiwgs, Providencia rettgerig, Pseudomonas aeruginosag+p+wgs, Pseudomonas fluorescenswgs, Pseudomonas monteiliiwgs, Pseudomonas putidap, Salmonella entericawgs, Serratia liquefaciensp, Shewanella putrefaciensp, Staphylococcus epidermidiswgs, Stenotrophomonas maltophiliawgs, Streptococcus mutansp, Vibrio choleraep+wgs |
| Resistomes with Sequence Variants | Achromobacter insolitusg+wgs, Achromobacter xylosoxidansg+wgs+gi, Acinetobacter baumanniig+wgs+gi, Actinobacillus pleuropneumoniaeg, Aeromonas caviaeg+wgs+gi, Aeromonas hydrophilag+wgs+gi, Aeromonas veroniip+gi, Alcaligenes faecalisgi, Bacillus subtilisg, Bacteroides fragiliswgs, Bifidobacterium bifidumwgs, Bifidobacterium brevewgs, Burkholderia cepaciag+wgs, Burkholderia pseudomalleiwgs, Chlamydia suisg+wgs+gi, Chlamydia trachomatisg+wgs+gi, Citrobacter freundiiwgs, Citrobacter portucalensiswgs, Citrobacter werkmaniiwgs, Citrobacter youngaewgs, Comamonas testosteronig, Cronobacter dublinensiswgs, Deinococcus radioduransg, Enterobacter asburiaewgs, Enterobacter cancerogenuswgs, Enterobacter cloacaeg+wgs, Enterobacter hormaecheip+wgs+gi, Enterobacter kobeiwgs, Enterobacter roggenkampiiwgs, Enterococcus faecaliswgs, Escherichia albertiiwgs, Escherichia colig+p+wgs+gi, Escherichia fergusoniip, Fusobacterium periodonticumwgs, Helicobacter cinaediwgs, Klebsiella aerogeneswgs+gi, Klebsiella oxytocawgs, Klebsiella pneumoniaeg+p+wgs+gi, Klebsiella quasipneumoniaewgs, Laribacter hongkongensiswgs+gi, Leclercia adecarboxylatawgs, Micrococcus luteuswgs, Moraxella osloensiswgs, Pasteurella multocidawgs, Phocaeicola doreiwgs, Proteus mirabilisg+wgs+gi, Proteus penneriwgs, Providencia rettgerig, Providencia stuartiiwgs, Pseudomonas aeruginosag+p+wgs+gi, Pseudomonas fluorescenswgs, Pseudomonas monteiliiwgs, Pseudomonas putidap, Pseudomonas stutzeriwgs, Pseudomonas synxanthag, Salmonella entericag+p+wgs+gi, Serratia liquefaciensp, Serratia marcescenswgs, Shewanella putrefaciensp, Shigella sonneiwgs, Staphylococcus aureuswgs, Staphylococcus epidermidiswgs, Stenotrophomonas maltophiliag+wgs, Streptococcus mutansp, Vibrio alginolyticuswgs, Vibrio choleraep+wgs, Vibrio parahaemolyticuswgs |
| Classification | 7 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic efflux [Resistance Mechanism] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + tetracycline antibiotic [Drug Class] |
| Parent Term(s) | 2 ontology terms | Show + confers_resistance_to_antibiotic tetracycline [Antibiotic] + major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family] |
| Publications | Peden KW, et al. 1985. Gene 22(2-3):277-80 Revised sequence of the tetracycline-resistance gene of pBR322. (PMID 6307828) |
Prevalence of tet(C) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Achromobacter insolitus | 60% | 0% | 57.14% | 0% |
| Achromobacter xylosoxidans | 13.04% | 0% | 2.29% | 28.57% |
| Acinetobacter baumannii | 0.18% | 0% | 0.06% | 2.52% |
| Actinobacillus pleuropneumoniae | 2.78% | 0% | 0% | 0% |
| Aeromonas caviae | 2.27% | 0% | 2.15% | 33.33% |
| Aeromonas hydrophila | 1.54% | 0% | 1.61% | 100% |
| Aeromonas veronii | 0% | 1.54% | 0% | 25% |
| Alcaligenes faecalis | 0% | 0% | 0% | 33.33% |
| Bacillus subtilis | 0.72% | 0% | 0% | 0% |
| Bacteroides fragilis | 0% | 0% | 0.27% | 0% |
| Bifidobacterium bifidum | 0% | 0% | 0.5% | 0% |
| Bifidobacterium breve | 0% | 0% | 0.6% | 0% |
| Burkholderia cepacia | 1.82% | 0% | 6.73% | 0% |
| Burkholderia pseudomallei | 0% | 0% | 0.06% | 0% |
| Chlamydia suis | 71.88% | 0% | 47.83% | 100% |
| Chlamydia trachomatis | 3.73% | 0% | 3.23% | 100% |
| Citrobacter freundii | 0% | 0% | 0.77% | 0% |
| Citrobacter portucalensis | 0% | 0% | 0.9% | 0% |
| Citrobacter werkmanii | 0% | 0% | 2.56% | 0% |
| Citrobacter youngae | 0% | 0% | 12.5% | 0% |
| Comamonas testosteroni | 20% | 0% | 0% | 0% |
| Cronobacter dublinensis | 0% | 0% | 2.56% | 0% |
| Deinococcus radiodurans | 20% | 0% | 0% | 0% |
| Enterobacter asburiae | 0% | 0% | 1.19% | 0% |
| Enterobacter cancerogenus | 0% | 0% | 14.29% | 0% |
| Enterobacter cloacae | 1.79% | 0% | 1.28% | 0% |
| Enterobacter hormaechei | 0% | 0.06% | 0.82% | 3.33% |
| Enterobacter kobei | 0% | 0% | 1.31% | 0% |
| Enterobacter roggenkampii | 0% | 0% | 0.36% | 0% |
| Enterococcus faecalis | 0% | 0% | 0.04% | 0% |
| Escherichia albertii | 0% | 0% | 1.94% | 0% |
| Escherichia coli | 0.17% | 0.05% | 0.85% | 3.19% |
| Escherichia fergusonii | 0% | 0.36% | 0% | 0% |
| Fusobacterium periodonticum | 0% | 0% | 14.29% | 0% |
| Helicobacter cinaedi | 0% | 0% | 1.96% | 0% |
| Klebsiella aerogenes | 0% | 0% | 0.28% | 25% |
| Klebsiella oxytoca | 0% | 0% | 0.42% | 0% |
| Klebsiella pneumoniae | 0.06% | 0.03% | 0.28% | 1.9% |
| Klebsiella quasipneumoniae | 0% | 0% | 0.79% | 0% |
| Laribacter hongkongensis | 0% | 0% | 2.08% | 50% |
| Leclercia adecarboxylata | 0% | 0% | 2.33% | 0% |
| Micrococcus luteus | 0% | 0% | 1.11% | 0% |
| Moraxella osloensis | 0% | 0% | 7.14% | 0% |
| Pasteurella multocida | 0% | 0% | 1.5% | 0% |
| Phocaeicola dorei | 0% | 0% | 1.04% | 0% |
| Proteus mirabilis | 17.43% | 0% | 3.8% | 25.93% |
| Proteus penneri | 0% | 0% | 12.5% | 0% |
| Providencia rettgeri | 5.88% | 0% | 0% | 0% |
| Providencia stuartii | 0% | 0% | 2.27% | 0% |
| Pseudomonas aeruginosa | 1.69% | 1.17% | 0.53% | 9.72% |
| Pseudomonas fluorescens | 0% | 0% | 0.43% | 0% |
| Pseudomonas monteilii | 0% | 0% | 2.38% | 0% |
| Pseudomonas putida | 0% | 4% | 0% | 0% |
| Pseudomonas stutzeri | 0% | 0% | 0.76% | 0% |
| Pseudomonas synxantha | 18.18% | 0% | 0% | 0% |
| Salmonella enterica | 0.06% | 0.16% | 0.69% | 5.3% |
| Serratia liquefaciens | 0% | 16.67% | 0% | 0% |
| Serratia marcescens | 0% | 0% | 0.13% | 0% |
| Shewanella putrefaciens | 0% | 20% | 0% | 0% |
| Shigella sonnei | 0% | 0% | 0.58% | 0% |
| Staphylococcus aureus | 0% | 0% | 0.01% | 0% |
| Staphylococcus epidermidis | 0% | 0% | 0.08% | 0% |
| Stenotrophomonas maltophilia | 1.12% | 0% | 0.45% | 0% |
| Streptococcus mutans | 0% | 33.33% | 0% | 0% |
| Vibrio alginolyticus | 0% | 0% | 0.4% | 0% |
| Vibrio cholerae | 0% | 5.26% | 0.13% | 0% |
| Vibrio parahaemolyticus | 0% | 0% | 0.1% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 500