MdtNOP

Accession ARO:3004101
Synonym(s)ycjRQP sdsRQP
DefinitionMdtNOP is a MFS efflux pump protein found in E. coli. The deletion of mdtP from strain W3110 resulted in increased susceptibility to acriflavin, puromycin, and tetraphenylarsonium chloride. An E. coli mdtN null mutant is more sensitive to sulfur drugs than wild type
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump
Drug Classtetracycline antibiotic, nucleoside antibiotic, bicyclomycin, cephalosporin, acridine dye, diaminopyrimidine antibiotic, macrolide antibiotic, nitroimidazole antibiotic, fosfomycin, lincosamide antibiotic, isoniazid, antibacterial free fatty acids, glycylcycline, fluoroquinolone antibiotic, rifamycin antibiotic, oxazolidinone antibiotic, peptide antibiotic, penam, phenicol antibiotic, rhodamine, benzalkonium chloride
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification31 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ confers_resistance_to_antibiotic acriflavine [Antibiotic]
+ confers_resistance_to_antibiotic puromycin [Antibiotic]
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family]
Sub-Term(s)
4 ontology terms | Show
+ mdtN part_of
+ mdtO part_of
+ mdtP part_of
+ leuO regulates
Publications

Shimada T, et al. 2009. J. Bacteriol. 191(14):4562-71 Involvement of the leucine response transcription factor LeuO in regulation of the genes for sulfa drug efflux. (PMID 19429622)

Dinh T, et al. 1994. J. Bacteriol. 176(13):3825-31 A family of extracytoplasmic proteins that allow transport of large molecules across the outer membranes of gram-negative bacteria. (PMID 8021163)

Resistomes

Prevalence of MdtNOP among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: efflux pump system meta-model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Name: MdtNOP

Model Description: MdtNOP is a MFS efflux pump protein found in E. coli. The deletion of mdtP from strain W3110 resulted in increased susceptibility to acriflavin, puromycin, and tetraphenylarsonium chloride. An E. coli mdtN null mutant is more sensitive to sulfur drugs than wild type

mdtPmdtNmdtO