Accession ARO:3003843
DefinitionleuO, a LysR family transcription factor, exists in a wide variety of bacteria of the family Enterobacteriaceae and is involved in the regulation of as yet unidentified genes affecting the stress response and pathogenesis expression. LeuO is also an activator of the MdtNOP efflux pump.
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump
Drug Classnucleoside antibiotic, acridine dye
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Efflux Regulatorprotein(s) and two-component regulatory system modulating antibiotic efflux
Classification12 ontology terms | Show
Parent Term(s)2 ontology terms | Show

Shimada T, et al. 2009. J. Bacteriol. 191(14):4562-71 Involvement of the leucine response transcription factor LeuO in regulation of the genes for sulfa drug efflux. (PMID 19429622)

Shimada T, et al. 2011. Mol. Microbiol. 82(2):378-97 Novel roles of LeuO in transcription regulation of E.‚ÄÉcoli genome: antagonistic interplay with the universal silencer H-NS. (PMID 21883529)