| Accession | ARO:3003548 |
| Synonym(s) | sdsR yjcR |
| CARD Short Name | mdtN |
| Definition | Multidrug resistance efflux pump. Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride. |
| AMR Gene Family | major facilitator superfamily (MFS) antibiotic efflux pump |
| Drug Class | nucleoside antibiotic, disinfecting agents and antiseptics |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Resistomes with Perfect Matches | Escherichia colig+p+wgs, Shigella boydiig+wgs, Shigella dysenteriaewgs, Shigella flexnerig+wgs, Shigella sonneiwgs |
| Resistomes with Sequence Variants | Escherichia albertiig+wgs, Escherichia colig+p+wgs, Escherichia marmotaeg+wgs, Klebsiella oxytocap, Shigella boydiig+wgs, Shigella dysenteriaeg+wgs, Shigella flexnerig+wgs, Shigella sonneig+wgs |
| Classification | 12 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + nucleoside antibiotic [Drug Class] + determinant of antibiotic resistance + antibiotic efflux [Resistance Mechanism] + disinfecting agents and antiseptics [Drug Class] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + aminonucleoside antibiotic + major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family] + puromycin [Antibiotic] + acriflavine [Antibiotic] |
| Parent Term(s) | 2 ontology terms | Show |
| Publications | Sulavik MC, et al. 2001. Antimicrob Agents Chemother 45(4): 1126-1136. Antibiotic susceptibility profiles of Escherichia coli strains lacking multidrug efflux pump genes. (PMID 11257026) Dinh T, et al. 1994. J. Bacteriol. 176(13):3825-31 A family of extracytoplasmic proteins that allow transport of large molecules across the outer membranes of gram-negative bacteria. (PMID 8021163) Shimada T, et al. 2009. J. Bacteriol. 191(14):4562-71 Involvement of the leucine response transcription factor LeuO in regulation of the genes for sulfa drug efflux. (PMID 19429622) |
Prevalence of mdtN among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Escherichia albertii | 98.57% | 0% | 58.71% | 0% |
| Escherichia coli | 66.87% | 0.02% | 61.02% | 0% |
| Escherichia marmotae | 100% | 0% | 70.83% | 0% |
| Klebsiella oxytoca | 0% | 0.68% | 0% | 0% |
| Shigella boydii | 60% | 0% | 60% | 0% |
| Shigella dysenteriae | 21.43% | 0% | 33.33% | 0% |
| Shigella flexneri | 99% | 0% | 80.43% | 0% |
| Shigella sonnei | 100% | 0% | 91.96% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 600