| Accession | ARO:3003549 |
| Synonym(s) | yjcQ sdsQ |
| Definition | Multidrug resistance efflux pump. Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride |
| AMR Gene Family | major facilitator superfamily (MFS) antibiotic efflux pump |
| Drug Class | nucleoside antibiotic, acridine dye |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Resistomes | Escherichia colig+wgs, Shigella dysenteriaewgs, Shigella flexneriwgs, Shigella sonneiwgs |
| Classification | 12 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + nucleoside antibiotic [Drug Class] + antibiotic efflux [Resistance Mechanism] + determinant of antibiotic resistance + acridine dye [Drug Class] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + aminonucleoside antibiotic + major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family] + puromycin [Antibiotic] + acriflavine [Antibiotic] |
| Parent Term(s) | 2 ontology terms | Show |
| Publications | Sulavik MC, et al. 2001. Antimicrob Agents Chemother 45(4): 1126-1136. Antibiotic susceptibility profiles of Escherichia coli strains lacking multidrug efflux pump genes. (PMID 11257026) Shimada T, et al. 2009. J. Bacteriol. 191(14):4562-71 Involvement of the leucine response transcription factor LeuO in regulation of the genes for sulfa drug efflux. (PMID 19429622) |
Prevalence of mdtO among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS |
|---|---|---|---|
| Acinetobacter nosocomialis | 0% | 0% | 2% |
| Citrobacter freundii | 0% | 0% | 1.55% |
| Escherichia coli | 13.02% | 0% | 85.75% |
| Klebsiella oxytoca | 0% | 0% | 0.93% |
| Klebsiella pneumoniae | 0% | 0% | 0% |
| Proteus penneri | 0% | 0% | 0% |
| Shigella dysenteriae | 50% | 0% | 74.29% |
| Shigella flexneri | 100% | 0% | 99.22% |
| Shigella sonnei | 100% | 0% | 97.88% |
| Staphylococcus aureus | 0% | 0% | 0.01% |
Model Type: protein homolog model
Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.
Bit-score Cut-off (blastP): 1300