tet(W/32/O)

Accession ARO:3007124
CARD Short Nametet(W/32/O)
DefinitionTet(W/32/O) is a mosaic tetracycline resistance gene and ribosomal protection protein.
AMR Gene Familytetracycline-resistant ribosomal protection protein
Drug Classtetracycline antibiotic
Resistance Mechanismantibiotic target protection
Resistomes with Perfect MatchesTrueperella pyogenesg+wgs
Resistomes with Sequence VariantsDysosmobacter welbioniswgs, Trueperella pyogenesg+wgs
Classification7 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ tetracycline-resistant ribosomal protection protein [AMR Gene Family]
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
Publications

Billington SJ, et al. 2002. Antimicrob Agents Chemother 46(5):1281-7 Widespread distribution of a tet W determinant among tetracycline-resistant isolates of the animal pathogen Arcanobacterium pyogenes. (PMID 11959557)

Resistomes

Prevalence of tet(W/32/O) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Dysosmobacter welbionis0%0%33.33%0%
Trueperella pyogenes46.67%0%8.33%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 875


>gb|AAL09826.1|+|tet(W/32/O) [Trueperella pyogenes]
MNIINIGILAHVDAGKTTLTESLLYASGTISEPGSVEKGTTRTDTMFLERQRGITIQTAVTSFQWHSCKVNIVDTPGHMDFLAEVYRSLA
VLDGAILVLSARDGVQAQTRVLFHALRKLNIPTIIFINKIDQVDIDLEGVYQSVRDKLSADIIIKQTVSLSPEIVLEENTDIEAWDAVIE
NNDGLLEKYIAGEPISREELAREEQRRVQAASLFPVYHGSAKNGLGIQRLMDAVIGLFQPTKEQGRTALCGSVFKVEYTDCGQRLVYLRL
YSGTLRLRDTVALAGREKLKITEMRIPSKGEIVRTDTAHKGEIVILPSDSLRLNDILGDKTQLPREMWSDAPFSMLRTTITPKTAEQRDR
LLDALTQIADTDPLLCYEVDSITQEIILSFLGRVQLEVVSALLAEKYKIETAVKEPTVIYLERPLKVASHTIHIEVPPNPFWASIGLSVT
PLPLGSGVQYESRVSLGYLNQSFQNAVMDGIRYGLEQGLCGWNVTDCKICFEYGLYYSPVSTPADFRSLAPIVLELALKESGTQLLEPYL
SFTLYAPQEYLSRAYHDAPKYCATIETAQIKKDEVVFTGEIPARCIQAYRTDLASYTNGRSVCLTELKGYQAAVGQPVIQPRRPNSRLDR
VRHMFQKVM


>gb|AY049983.2|+|8309-10228|tet(W/32/O) [Trueperella pyogenes]
ATGAACATTATCAATATCGGGATTCTTGCCCATGTAGATGCGGGCAAGACGACACTGACAGAAAGCCTGCTGTATGCCAGCGGAACCATT
TCAGAGCCGGGGAGCGTCGAAAAAGGGACAACGAGAACGGACACTATGTTTTTGGAGCGGCAGCGTGGAATTACCATTCAAACGGCAGTC
ACTTCTTTCCAGTGGCACAGTTGTAAAGTCAACATTGTGGATACTCCCGGCCACATGGATTTCTTGGCAGAGGTATACCGCTCTCTGGCC
GTTTTGGACGGGGCCATCTTGGTGCTCTCCGCTAGAGATGGCGTACAGGCCCAGACCCGAGTTCTGTTCCATGCCCTACGGAAATTGAAC
ATCCCCACCATTATCTTTATCAACAAGATCGACCAGGTTGACATTGATTTGGAGGGCGTATATCAGTCTGTTCGGGATAAGCTCTCCGCC
GATATTATCATCAAGCAGACGGTATCGCTGTCCCCGGAAATAGTTCTGGAGGAAAATACCGACATAGAAGCATGGGATGCGGTCATCGAA
AATAACGATGGATTATTGGAAAAGTATATCGCAGGAGAGCCAATCAGCCGGGAAGAACTTGCGCGGGAGGAACAGCGGCGGGTTCAAGCC
GCTTCCCTGTTCCCAGTCTATCATGGTAGCGCCAAAAACGGCCTTGGCATTCAACGGTTGATGGATGCGGTGATAGGGCTGTTCCAACCG
ACCAAGGAACAGGGGCGCACCGCCCTGTGCGGCAGCGTTTTCAAGGTGGAGTATACAGATTGCGGCCAGAGGCTTGTCTATCTGCGGCTA
TACAGCGGAACGCTGCGTCTGCGGGATACGGTGGCCCTGGCCGGGAGAGAAAAGCTGAAAATCACAGAGATGCGTATTCCATCCAAAGGG
GAGATTGTTCGGACAGATACCGCCCATAAGGGCGAAATTGTCATCCTTCCCAGCGACAGTTTGAGATTAAACGATATATTGGGGGACAAA
ACCCAACTTCCTCGTGAAATGTGGAGTGATGCTCCCTTCTCTATGCTGCGGACAACGATTACGCCAAAAACGGCAGAGCAAAGAGATCGG
TTGCTGGACGCTCTTACGCAAATTGCGGATACTGACCCGCTTTTGTGCTACGAGGTGGATTCCATCACCCAAGAGATCATTCTTTCTTTT
TTGGGCCGGGTGCAGTTGGAGGTTGTTTCCGCTTTGCTGGCGGAAAAGTATAAGATTGAAACAGCGGTGAAGGAACCCACCGTCATTTAT
TTAGAGCGGCCGCTCAAAGTGGCCAGCCACACCATCCATATCGAGGTGCCGCCCAACCCGTTTTGGGCATCCATCGGACTGTCTGTTACG
CCGCTCCCGCTTGGCTCCGGTGTACAATACGAGAGCCGGGTTTCCCTGGGATACTTGAACCAGAGTTTTCAAAACGCTGTCATGGATGGT
ATCCGTTACGGTCTGGAGCAAGGCTTGTGTGGCTGGAACGTAACGGACTGTAAGATTTGCTTTGAATACGGGCTTTATTATAGCCCGGTC
AGCACGCCGGCGGACTTTCGCTCATTGGCCCCGATTGTATTGGAACTGGCATTAAAGGAATCAGGGACACAGTTGCTGGAACCTTATCTC
TCCTTCACCCTCTATGCGCCCCAGGAATACCTTTCCAGGGCTTATCATGATGCGCCGAAATATTGTGCCACCATCGAAACGGCCCAGATA
AAAAAGGATGAAGTTGTCTTTACTGGCGAGATTCCCGCCCGTTGCATACAGGCATACCGTACTGATTTGGCCTCTTACACCAATGGGCGG
AGCGTGTGCCTGACGGAACTGAAAGGGTATCAGGCCGCTGTCGGCCAGCCGGTCATCCAGCCCCGCCGTCCAAACAGCCGCCTGGACAGG
GTGCGCCATATGTTTCAGAAGGTAATGTAA