| Accession | ARO:3000196 |
| Synonym(s) | tet32 |
| CARD Short Name | tet(32) |
| Definition | Tet(32) is a tetracycline resistance gene similar to Tet(O), and binds to the ribosome to confer tetracycline resistance as a ribosomal protection protein. |
| AMR Gene Family | tetracycline-resistant ribosomal protection protein |
| Drug Class | tetracycline antibiotic |
| Resistance Mechanism | antibiotic target protection |
| Resistomes with Perfect Matches | Lachnospiraceae bacteriumgi, Ruthenibacterium lactatiformanswgs, Streptococcus anginosusg+wgs, Streptococcus pseudopneumoniaewgs, Streptococcus suiswgs |
| Resistomes with Sequence Variants | Campylobacter concisusg, Collinsella aerofacienswgs, Enterocloster clostridioformiswgs, Enterococcus faecalisg, Erysipelatoclostridium ramosumwgs, Eubacterium limosumg+gi, Faecalibacterium prausnitziiwgs, Lachnospiraceae bacteriumgi, Massilistercora timonensisg, Roseburia hominiswgs, Ruthenibacterium lactatiformanswgs, Streptococcus anginosusg+wgs, Streptococcus constellatusg, Streptococcus intermediuswgs, Streptococcus pneumoniaeg+wgs, Streptococcus pseudopneumoniaewgs, Streptococcus suiswgs, Treponema denticolag |
| Classification | 7 ontology terms | Show |
| Parent Term(s) | 7 ontology terms | Show + tetracycline-resistant ribosomal protection protein [AMR Gene Family] + confers_resistance_to_antibiotic doxycycline [Antibiotic] + confers_resistance_to_antibiotic minocycline [Antibiotic] + confers_resistance_to_antibiotic chlortetracycline [Antibiotic] + confers_resistance_to_antibiotic demeclocycline [Antibiotic] + confers_resistance_to_antibiotic oxytetracycline [Antibiotic] + confers_resistance_to_antibiotic tetracycline [Antibiotic] |
| Publications | Warburton P, et al. 2008. Antimicrob Agents Chemother 53(1): 273-276. Characterization of tet(32) genes from the oral metagenome. (PMID 18955517) Melville CM, et al. 2001. Antimicrob Agents Chemother 45(11): 3246-3249. Novel tetracycline resistance gene, tet(32), in the Clostridium-related human colonic anaerobe K10 and its transmission in vitro to the rumen anaerobe Butyrivibrio fibrisolvens. (PMID 11600392) |
Prevalence of tet(32) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Campylobacter concisus | 6.25% | 0% | 0% | 0% |
| Collinsella aerofaciens | 0% | 0% | 1.49% | 0% |
| Enterocloster clostridioformis | 0% | 0% | 20.93% | 0% |
| Enterococcus faecalis | 0.45% | 0% | 0% | 0% |
| Erysipelatoclostridium ramosum | 0% | 0% | 4.65% | 0% |
| Escherichia coli | 0% | 0% | 0% | 0% |
| Eubacterium limosum | 25% | 0% | 0% | 100% |
| Faecalibacterium prausnitzii | 0% | 0% | 0.97% | 0% |
| Lachnospiraceae bacterium | 0% | 0% | 0% | 33.33% |
| Massilistercora timonensis | 100% | 0% | 0% | 0% |
| Roseburia hominis | 0% | 0% | 11.11% | 0% |
| Ruthenibacterium lactatiformans | 0% | 0% | 13.33% | 0% |
| Streptococcus anginosus | 5.88% | 0% | 2.92% | 0% |
| Streptococcus constellatus | 25% | 0% | 0% | 0% |
| Streptococcus intermedius | 0% | 0% | 4.55% | 0% |
| Streptococcus pneumoniae | 0.49% | 0% | 0.02% | 0% |
| Streptococcus pseudopneumoniae | 0% | 0% | 0.85% | 0% |
| Streptococcus suis | 0% | 0% | 0.16% | 0% |
| Treponema denticola | 6.67% | 0% | 0% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 300